The p53 network: cellular and systemic DNA damage responses in aging and Cancer

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Thymocyte apoptosis induced by p53-dependent and independent pathways

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051 · see citing works

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre’, M., Giovanni Nuciforo, P., Bensimon, A., et al. (2006) · Nature · doi:10.1038/nature05327 · Cited by 1,821 · see citing works

Restoration of p53 function leads to tumour regression in vivo

Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · see citing works

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works

Impact of mutant p53 functional properties on <i>TP53</i> mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation · doi:10.1002/humu.20495 · Cited by 1,598 · see citing works

Rate of depurination of native deoxyribonucleic acid

Lindahl, T. L., & Nyberg, B. (1972) · Biochemistry · doi:10.1021/bi00769a018 · Cited by 1,558 · see citing works

p53 Status and the Efficacy of Cancer Therapy in Vivo

Lowe, S. W., Bodis, S. B., McClatchey, A. I., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., & Jacks, T. (1994) · Science · doi:10.1126/science.7973635 · Cited by 1,470 · see citing works

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · see citing works

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2012 · Cited by 1,286 · see citing works

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., & Vogelstein, B. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00213-1 · Cited by 1,282 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes &amp; Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215 · see citing works

Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121 · see citing works

Dynamics of the p53-Mdm2 feedback loop in individual cells

Lahav, G., Rosenfeld, N., Sigal, A., Geva‐Zatorsky, N., Levine, A. J., Elowitz, M. B., & Alon, U. (2004) · Nature Genetics · doi:10.1038/ng1293 · Cited by 1,015 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

Regulation of PTEN Transcription by p53

Stambolic, V., MacPherson, D. P., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., & Mak, T. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00323-9 · Cited by 913 · see citing works

The Regulation of Notch Signaling Controls Satellite Cell Activation and Cell Fate Determination in Postnatal Myogenesis

Conboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905 · see citing works

Inflammation: Gearing the journey to cancer

Kundu, J. K., & Surh, Y. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.03.002 · Cited by 804 · see citing works

The retinoblastoma tumour suppressor in development and cancer

Classon, M., & Harlow, E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc950 · Cited by 738 · see citing works

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703 · see citing works

DNA damage response and cellular senescence in tissues of aging mice

Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 663 · see citing works

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633 · see citing works

Modeling the Therapeutic Efficacy of p53 Restoration in Tumors

Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600 · see citing works

Modulation of mammalian life span by the short isoform of p53

Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes &amp; Development · doi:10.1101/gad.1162404 · Cited by 586 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Insulin-like growth factors and cancer

Fürstenberger, G., & Senn, H.-J. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00731-3 · Cited by 538 · see citing works

'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally

García‐Cao, I., García‐Cao, M., Martín‐Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J., Blasco, M. A., & Serrano, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf595 · Cited by 529 · see citing works

A Conserved Regulatory System for Aging

Kenyon, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00306-3 · Cited by 529 · see citing works

Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion

Liu, D., & Hornsby, P. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3452 · Cited by 499 · see citing works

Delayed ageing through damage protection by the Arf/p53 pathway

Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works

Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance

Derry, W. B., Putzke, A. P., & Rothman, J. H. (2001) · Science · doi:10.1126/science.1065486 · Cited by 464 · see citing works

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Coppé, J.-P., Patil, C. K., Rodier, F., Krtolica, A., Beauséjour, C. M., Parrinello, S., Hodgson, J. G., Chin, K., Desprez, P.-Y., & Campisi, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009188 · Cited by 455 · see citing works

The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms

Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

Batchelor, E., Mock, C. S., Bhan, I., Loewer, A., & Lahav, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.016 · Cited by 422 · see citing works

Muscle transplantation between young and old rats: age of host determines recovery

Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417 · see citing works

Two faces of p53: aging and tumor suppression

Rodier, F., Campisi, J., & Bhaumik, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm744 · Cited by 399 · see citing works

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Nature · doi:10.1038/nature05077 · Cited by 382 · see citing works

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

Feng, Z., & Levine, A. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.004 · Cited by 359 · see citing works

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

Schumacher, B., Hofmann, K., Boulton, S. J., & Gartner, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00534-6 · Cited by 355 · see citing works

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0431 · Cited by 317 · see citing works

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

Paradis, V., Youssef, N., Dargère, D., Bâ, N., Bonvoust, F., Deschatrette, J., & Bedossa, P. (2001) · Human Pathology · doi:10.1053/hupa.2001.22747 · Cited by 314 · see citing works

Advances in Chemical Carcinogenesis: A Historical Review and Prospective

Loeb, L. A., & Harris, C. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2852 · Cited by 314 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works

Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis

Hofmann, E. R., Milstein, S., Boulton, S. J., Ye, M., Hofmann, J., Stergiou, L., Gartner, A., Vidal, M., & Hengartner, M. O. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01262-9 · Cited by 280 · see citing works

Age to survive: DNA damage and aging

Schumacher, B., Garinis, G. A., & Hoeijmakers, J. H. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.004 · Cited by 255 · see citing works

Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease

Erusalimsky, J. D., & Kurz, D. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.010 · Cited by 252 · see citing works

The ups and downs of p53: understanding protein dynamics in single cells

Batchelor, E., Loewer, A., & Lahav, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2604 · Cited by 242 · see citing works

DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

Poulogiannis, G., Frayling, I. M., & Arends, M. J. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03392.x · Cited by 242 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

Millis, A. J. T., Hoyle, M., McCue, H. M., & Martini, H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90286-h · Cited by 239 · see citing works

Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

van der Pluijm, I., Garinis, G. A., Brandt, R. M. C., Gorgels, T. G. M. F., Wijnhoven, S., Diderich, K. E. M., de Wit, J., Mitchell, J. R., van Oostrom, C., Beems, R. B., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0050002 · Cited by 237 · see citing works

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

Kirkwood, T. B. L., & Cremer, T. J. (1982) · Human Genetics · doi:10.1007/bf00569695 · Cited by 236 · see citing works

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening

Melk, A., Kittikowit, W., Sandhu, I., Halloran, K. M., Grimm, P., Schmidt, B. M. W., & Halloran, P. F. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00032.x · Cited by 205 · see citing works

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage

Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., Conradt, B., & Shaham, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401539 · Cited by 186 · see citing works

No PUMA, no death

Yu, J., & Zhang, L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00249-6 · Cited by 180 · see citing works

Dietary factors and the risk of endometrial cancer

Levi, F., Vecchia, C. L., Franceschi, S., & Negri, E. (1993) · Cancer · doi:10.1002/1097-0142(19930601)71:11 · Cited by 175 · see citing works

A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan

Carter, C. S., Ramsey, M. M., & Sonntag, W. E. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02696-3 · Cited by 163 · see citing works

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Garinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., van Steeg, H., Mullenders, L. H. F., van der Horst, G. T. J., Brüning, J. C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1866 · Cited by 138 · see citing works

Skeletal Muscle Regeneration in Very Old Rats

Carlson, B. M., Dedkov, E. I., Borisov, A. B., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b224 · Cited by 119 · see citing works

The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland

Young, L. J. T., Medina, D., DeOme, K. B., & Daniel, C. W. (1971) · Experimental Gerontology · doi:10.1016/0531-5565(71)90048-9 · Cited by 116 · see citing works

Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway

Bartholomew, J. N., Volonté, D., & Galbiati, F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2857 · Cited by 106 · see citing works

Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation.

Rovinski, B., Munroe, D. G., Peacock, J. W., Mowat, M. R. A., Bernstein, A., & Benchimol, S. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.847 · Cited by 96 · see citing works

Senescence-associated genes in normal human oral keratinocytes

Kang, M. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00061-2 · Cited by 89 · see citing works

Distribution of Stage I Lung Cancer Growth Rates Determined with Serial Volumetric CT Measurements

Jennings, S. G., Winer-Muram, H. T., Tann, M. A., et al. (2006) · Radiology · doi:10.1148/radiol.2412051185 · Cited by 87 · see citing works

Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae

Weinert, T. A., & Hartwell, L. H. (1989) · Journal of Cell Science · doi:10.1242/jcs.1989.supplement_12.12 · Cited by 87 · see citing works

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

Ramírez, C. L. J., Cadiñanos, J., Varela, I., Freije, J. M. P., & López-Otı́n, C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6349-3 · Cited by 83 · see citing works

Targeting the IGF1 axis in cancer proliferation

Bruchim, I., Attias-Geva, Z., & Werner, H. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903201702 · Cited by 81 · see citing works

Hereditary breast cancer growth rates and its impact on screening policy

Tilanus‐Linthorst, M. M. A., Kriege, M., Boetes, C., Hop, W. C. J., Obdeijn, I.-M., Oosterwijk, J. C., Peterse, H. L., Zonderland, H. M., Meijer, S., Eggermont, A. M. M., et al. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.02.034 · Cited by 77 · see citing works

Epithelioid sarcoma. A light and electron microscopic study suggesting a synovial origin

Gabbiani, G., Fu, Y., Kaye, G. I., Lattes, R., & Majno, G. (1972) · Cancer · doi:10.1002/1097-0142(197208)30:2 · Cited by 72 · see citing works

Distribution of Renal Tumor Growth Rates Determined by Using Serial Volumetric CT Measurements

Zhang, J., Kang, S. K., Wang, L., et al. (2008) · Radiology · doi:10.1148/radiol.2501071712 · Cited by 69 · see citing works

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

Hinkal, G. W., Parikh, N., & Donehower, L. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006654 · Cited by 68 · see citing works

Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment

Kavurma, M. M., Figg, N. L., Bennett, M. R., Mercer, J. R., Khachigian, L. M., & Littlewood, T. D. (2007) · Biochemical Journal · doi:10.1042/bj20070380 · Cited by 49 · see citing works

Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT

Bhatia, B., Multani, A. S., Patrawala, L., Chen, X., Calhoun‐Davis, T., Zhou, J., Schroeder, L., Schneider‐Broussard, R., Shen, J., Pathak, S., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23222 · Cited by 47 · see citing works

Senescence Induces a Proangiogenic Switch in Human Peritoneal Mesothelial Cells

Książek, K., Jörres, A., & Witowski, J. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0736 · Cited by 36 · see citing works

Inflammation, aging, and cancer vaccines

Provinciali, M., Barucca, A., Cardelli, M., Marchegiani, F., & Pierpaoli, E. (2010) · Biogerontology (Dordrecht) · doi:10.1007/s10522-010-9280-9 · Cited by 30 · see citing works

Deletion of 5′-coding Sequences of the Cellular p53 Gene in Mouse Erythroleukemia: A Novel Mechanism of Oncogene Regulation

Rovinski, B., Munroe, D. G., Peacock, J., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.847-853.1987 · Cited by 30 · see citing works

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649 · see citing works

Revisiting Li-Fraumeni Syndrome From <i>TP53</i> Mutation Carriers

Bougeard, G., Renaux-Petel, M., Flaman, J.-M., Charbonnier, C., Fermey, P., Belotti, M., Gauthier-Villars, M., Stoppa-Lyonnet, D., Consolino, E., Brugières, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.5728 · Cited by 760 · see citing works

Stress, Inflammation, and Defense of Homeostasis

Chovatiya, R., & Medzhitov, R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.030 · Cited by 704 · see citing works

Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, K. K., & Li, S. S.-C. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3915 · Cited by 479 · see citing works

DNA damage responses and p53 in the aging process

Ou, H.-L., & Schumacher, B. (2018) · Blood · doi:10.1182/blood-2017-07-746396 · Cited by 377 · see citing works

DNA damage-how and why we age?

Yousefzadeh, M., Henpita, C., Vyas, R., Soto-Palma, C., Robbins, P., & Niedernhofer, L. (2021) · eLife · doi:10.7554/elife.62852 · Cited by 399 · see citing works

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207 · see citing works

T-cell aging in rheumatoid arthritis

Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000011 · Cited by 164 · see citing works

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

Loayza-Puch, F., Drost, J., Rooijers, K., Lopes, R., Elkon, R., & Agami, R. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r32 · Cited by 114 · see citing works

RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage

Ho, S.-R., Mahanic, C. S., Lee, Y.-J., & Lin, W.-C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323107111 · Cited by 88 · see citing works

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

Lerner, L. K., Francisco, G., Soltys, D. T., Rocha, C. R. R., Quinet, A., Vessoni, A. T., Castro, L. P., David, T. I. P., Bustos, S. O., Strauss, B. E., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1196 · Cited by 53 · see citing works

miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O

Chen, B., Duan, L., Yin, G., Tan, J., & Jiang, X. (2013) · Journal of Chemotherapy · doi:10.1179/1973947813y.0000000092 · Cited by 51 · see citing works

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization

Tommasi, S., Zheng, A., Weninger, A., Bates, S. E., Li, X. A., Wu, X., Hollstein, M., & Besaratinia, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1051 · Cited by 45 · see citing works

The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction

Vodicka, P., Andera, L., Opattova, A., & Vodickova, L. (2021) · Cancers · doi:10.3390/cancers13030479 · Cited by 39 · see citing works

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva, N. S., Siewiera, J., Alkhoury, C., Nader, G. P. F., Nadalin, F., de Azevedo, K., Couty, M., Izquierdo, H. M., Bhargava, A., Conrad, C., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00488-w · Cited by 34 · see citing works

Tumor suppression by p53: making cells senescent.

Qian, Y., & Chen, X. (2010) · PubMed · doi:10.14670/hh-25.515 · Cited by 85 · see citing works

Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair

Yoshioka, K., Kusumoto‐Matsuo, R., Matsuno, Y., & Ishiai, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212254 · Cited by 60 · see citing works

Molecular chaperones in DNA repair mechanisms: Role in genomic instability and proteostasis in cancer

Hasan, A., Rizvi, S. F., Parveen, S., & Mir, S. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120852 · Cited by 9 · see citing works

Paradoxical suppression of cellular senescence by p53

Demidenko, Z. N., Korotchkina, L. G., Gudkov, A. V., & Blagosklonny, M. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002298107 · Cited by 273 · see citing works

Nucleotide excision repair in aging & cancer

Melis, J. P. M. (2012) · Leiden Repository (Leiden University)