THE CLEARANCE OF VASOPRESSIN AND DEAMINOVASOPRESSIN FROM THE CIRCULATION OF NORMAL AND HYPERCALCAEMIC RABBITS
Abstract
Some of the binding reactions between neurohypophysial hormones and protein are inhibited by calcium. This is true of binding with neurophysin (Smith & Thorn, 1965; Ginsburg, Jayasena & Thomas, 1966), with serum protein (Smith & Thorn, 1965) and of the uptake of vasopressin by kidney slices (Smith, 1963; Thorn & Willumsen, 1963a, b). The binding to neurophysin and to kidney protein and the uptake by the kidney appear to be dependent on a cysteinyl-free amino group, since deamino analogues of vasopressin and oxytocin are not bound or taken up (Stouffer, Hope & du Vigneaud, 1963; Chan, 1965; Ginsburg & Jayasena, 1968). One of the consequences of inhibition of binding to plasma protein by calcium appears to be the prolongation of the half-life of vasopressin in the circulation in rats (Smith & Thorn, 1965) and it seemed of interest, therefore, to investigate the effect of hypercalcaemia on the clearance of
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In rabbits, vasopressin was cleared with a half-life of approximately 4.5 min, mainly by the kidneys and liver.
“In similar studies on rabbits, vasopressin was cleared with a half‐life of approximately 4.5 min, again mainly by the kidneys and liver 105.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [105]
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Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237 · see citing works
“The erroneous baseline level is unaffected, but the exaggeration is reduced; here, the gain is three-fold. half-life of approximately 4.5 min, again mainly by the kidneys and liver (105).”
BackgroundInfluential
- Authors
- HASAN, S. H.
- Corresponding author
- HASAN, S. H.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1970-05-01
- Volume
- 47
- Issue
- 1
- Pages
- 135-136
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2143147722
- Cited by
- 1
- References
- 0
- Citations by year
- 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- vasopressin, hypercalcemia, plasma clearance, neurophysin, neurohypophyseal hormones, oxytocin
- MeSH terms
- Animals, Arginine, Calcium Chloride, Hepatectomy, Hypercalcemia, Metabolic Clearance Rate, Nephrectomy, Rabbits, Vasopressins
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