EFFECT OF NEONATAL ADMINISTRATION OF STEROIDS OR GONADECTOMY UPON OESTRADIOL-INDUCED LUTEINIZING HORMONE RELEASE IN RATS OF BOTH SEXES
Abstract
SUMMARY: Implantation of oestradiol into adult rats of both sexes induced different patterns of LH secretion depending on the time at which gonadectomy or testosterone injection were performed. Castration 2 h after birth allowed an LH peak to occur daily at 18.00 h, but its amplitude was lower than that of adult gonadectomized female rats treated with oestradiol. Castration 24 h after birth elicited two kinds of response; a circadian discharge of LH lower than that of male rats gonadectomized 2 h after birth or a steady low level of LH. The LH rhythmicity induced by implantation of oestradiol was not seen after castration at 8 weeks of age. Neonatal administration of testosterone to female rats prevented the LH peak induced by oestradiol that was seen in adult ovariectomized rats. Neonatal or adult ovariectomy did not interfere with the rhythmical response of LH after implantation of oestradiol. Thus, it is concluded that sexual differentiation of the hypothalamus is primarily of masculine origin.
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Positive feedback is sexually differentiated: male rodents cannot produce an LH surge in response to elevated estradiol.
“This positive feedback response is a sexually differentiated phenomenon, where male rodents are incapable of responding to elevated estradiol with a surge of LH (Corbier, 1985; Gogan, Beattie, Hery, Laplante, & Kordon, 1980; Olster & Blaustein, 1991).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Gogan, Beattie, Hery, Laplante, & Kordon, 1980
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- Authors
- GOGAN, F., BEATTIE, I. A., HERY, M., LAPLANTE, E., & KORDON, C.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1980-04-01
- Volume
- 85
- Issue
- 1
- Pages
- 69-74
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2076924632
- Cited by
- 40
- References
- 0
- Citations by year
- 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- luteinizing hormone secretion, estradiol, neonatal castration, neonatal testosterone, gonadectomy, circadian rhythm, ovariectomy
- MeSH terms
- Animals, Animals, Newborn, Castration, Estradiol, Female, Hypothalamus, Luteinizing Hormone, Male, Secretory Rate, Testosterone, Rats
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