Hypersecretion of corticotrophin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion
Open accessAbstract
The relationship between hypothyroidism and disturbance of the hypothalamo-hypophysial-adrenal axis was investigated using adult male rats. Hypothyroidism was produced by administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Hypothyroidism decreased adrenal weights to 57% of controls and plasma concentrations of corticosterone to 48% of controls. The changes in the weight of adrenals recovered to control levels by administration of thyroxine. The pituitary responsiveness to corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) for ACTH release markedly increased in hypothyroid rats as compared with euthyroid rats. In vivo release of CRH and AVP in median eminence significantly increased in hypothyroid rats as compared with euthyroid rats. There were no significant differences in hypothalamic concentrations of CRH and AVP. These results indicate that hypothyroidism causes adrenal dysfunction directly and results in hypersecretion of ACTH mediated by increases in synthesis of CRH and AVP in the hypothalamus.
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In the presence of reduced PRA, ALDO secretion could be sustained by ACTH.
“In the presence of a reduced PRA, ALDO secretion could be sustained by the pituitary hormone ACTH; according to this finding, recent studies have reported a reactive increase in ACTH secretion in response to adrenal cortex dysfunction induced by acute hypothyroidism in experimental animals (33,34).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [34]
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Self-citation
- Authors
- Tohei, A., Watanabe, G., & Taya, K.
- Affiliations
- Tokyo University of Agriculture and Technology (JP)
- ORCID
- Watanabe, G
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1998-02-01
- Volume
- 156
- Issue
- 2
- Pages
- 395-400
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2155626371
- Cited by
- 25
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Colorado State University
- Hirosaki University
- Soochow University
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothyroidism, corticotropin-releasing factor, vasopressin, ACTH secretion, adrenal dysfunction, thyroxine, median eminence, hypothalamus, corticosterone, rats
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Analysis of Variance, Animals, Arginine Vasopressin, Corticosterone, Corticotropin-Releasing Hormone, Hypothyroidism, Male, Median Eminence, Organ Size, Perfusion, Pituitary Gland, Thiouracil, Rats, Wistar, Rats
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