The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Beta cell differentiation during early human pancreas development
Abstract
Understanding gene expression profiles during early human pancreas development is limited by comparison to studies in rodents. In this study, from the inception of pancreatic formation, embryonic pancreatic epithelial cells, approximately half of which were proliferative, expressed nuclear PDX1 and cytoplasmic CK19. Later, in the fetal pancreas, insulin was the most abundant hormone detected during the first trimester in largely non-proliferative cells. At sequential stages of early fetal development, as the number of insulin-positive cell clusters increased, the detection of CK19 in these cells diminished. PDX1 remained expressed in fetal beta cells. Vascular structures were present within the loose stroma surrounding pancreatic epithelial cells during embryogenesis. At 10 weeks post-conception (w.p.c.), all clusters containing more than ten insulin-positive cells had developed an intimate relationship with these vessels, compared with the remainder of the developing pancreas. At 12-13 w.p.c., human fetal islets, penetrated by vasculature, contained cells independently immunoreactive for insulin, glucagon, somatostatin and pancreatic polypeptide (PP), coincident with the expression of maturity markers prohormone convertase 1/3 (PC1/3), islet amyloid polypeptide, Chromogranin A and, more weakly, GLUT2. These data support the function of fetal beta cells as true endocrine cells by the end of the first trimester of human pregnancy.
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Cites
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Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Rezania, A., Bruin, J. E., Riedel, M. J., Mojibian, M., Asadi, A., Xu, J., Gauvin, R., Narayan, K., Karanu, F., O’Neil, J. J., et al. (2012) · Diabetes · doi:10.2337/db11-1711 · Cited by 582
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
Goto, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25091 · Cited by 284
Borden, P., Houtz, J., Leach, S. D., & Kuruvilla, R. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.019 · Cited by 192
Metadata
- Authors
- Piper, K., Brickwood, S., Turnpenny, L., Cameron, I., Ball, S., Wilson, D., & Hanley, N.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2004-04-01
- Volume
- 181
- Issue
- 1
- Pages
- 11-23
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2095672168
- Cited by
- 313
- References
- 35
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Piper, K., Brickwood, S., Turnpenny, L., Cameron, I., Ball, S., Wilson, D., & Hanley, N. (2004). Beta cell differentiation during early human pancreas development. Journal of Endocrinology. https://doi.org/10.1677/joe.0.1810011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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