Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation
Open accessAbstract
Sympathetic neurons depend on target-derived neurotrophic cues to control their survival and growth. However, whether sympathetic innervation contributes reciprocally to the development of target tissues is less clear. Here, we report that sympathetic innervation is necessary for the formation of the pancreatic islets of Langerhans and for their functional maturation. Genetic or pharmacological ablation of sympathetic innervation during development resulted in altered islet architecture, reduced insulin secretion, and impaired glucose tolerance in mice. Similar defects were observed with pharmacological blockade of β-adrenergic signaling. Conversely, the administration of a β-adrenergic agonist restored islet morphology and glucose tolerance in deinnervated animals. Furthermore, in neuron-islet cocultures, sympathetic neurons promoted islet cell migration in a β-adrenergic-dependent manner. This study reveals that islet architecture requires extrinsic inductive cues from neighboring tissues such as sympathetic nerves and suggests that early perturbations in sympathetic innervation might underlie metabolic disorders.
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The pancreas is highly innervated with parasympathetic and sympathetic nerve fibers from the autonomic nervous system.
“The pancreas is highly innervated with both, parasympathetic99, 100 and sympathetic100, 101 nerve fibers from the autonomic nervous system.”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [101]
The Introduction states that the pancreas is richly innervated by sympathetic nerves and identifies the sympathetic nervous system as a branch of the autonomic nervous system. Our copy does not establish the claimed parasympathetic innervation; the cited paper supports only the sympathetic part of the sentence. Page numbers were not available in the copy. (LLM, conf=0.86)
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- Authors
- Borden, P., Houtz, J., Leach, S. D., & Kuruvilla, R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Kuruvilla, Rejji
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 4
- Issue
- 2
- Pages
- 287-301
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3740126
- OpenAlex
- W1995319214
- Cited by
- 192
- References
- 81
- Citations by year
- 2026: 20 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 22 · 2021: 21 · 2020: 15 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 1
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056211, R21DK090624, P30DK079637)
- National Institute of Neurological Disorders and Stroke (R01NS073751)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- sympathetic innervation, pancreatic islets, islet development, islet architecture, beta-adrenergic signaling, beta-adrenergic agonists, insulin secretion, glucose tolerance, metabolic disorders
- MeSH terms
- Insulin Secretion, Animals, Cell Communication, Cell Movement, Female, Glucose, Insulin, Islets of Langerhans, Male, Mice, Transgenic, Neurons, Norepinephrine, Pregnancy, Receptors, Adrenergic, beta, Sympathetic Nervous System, Signal Transduction, Mice
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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