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Cited by 195Cerebrospinal fluid and hydrocephalusIon Transport and Channel RegulationGenetic and Kidney Cyst Diseases

The system of cerebrospinal fluid-contacting neurons.

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VIGH-TEICHMANN, Ingeborg, VIGH, Béla·1983·Archivum histologicum japonicum
DOI 10.1679/aohc.46.427
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Abstract

Cerebrospinal fluid (CSF)-contacting neurons are located periventricularly or inside the brain ventricles; they contact the CSF via their dendrites, perikarya or axons. Most of the CSF-contacting nerve cells send dendritic processes into the ventricular cavity where they form ciliated terminals. These ciliated dendritic endings resemble those of known sensory cells, yet their role is still unknown. There are two types of CSF-contacting dendritic terminals. One bears solitary 9 X 2 + 0 cilia; it is present in different hypothalamic regions such as the paraventricular organ and the vascular sac. The magnocellular neurosecretory nuclei also contain CSF-contacting neurons, which probably furnish information about the parameters of the CSF for the regulatory function of the hypothalamo-hypophyseal system. CSF-contacting nerve cells of the parvocellular hypothalamic nuclei are suspected to participate in hypothalamo-adenohypophyseal regulation. A second type of CSF-contacting dendritic terminal bears many stereocilia and is found in the central canal of the spinal cord. This type of terminal is also supplied with a 9 X 2 + 2 kinocilium that may contact Reissner's fiber, the secretory material of the subcommissural organ. Resembling mainly mechanoreceptors, these spinal CSF-contacting neurons appear to form axon terminals of the neurosecretory type at the external circumference of the spinal cord. Developing and/or regressing photoreceptor cells of the retina and pineal complex may display a similar dendritic structure characteristic of hypothalamic CSF-contacting neurons. Axons penetrating into the ventricles innervate the apical surface of the ependyma and/or the CSF-contacting dendritic terminals. Some bipolar neurons of the retina form so-called Landolt's clubs; these may be considered as the retinal component of the CSF-contacting neuronal system. Since in the lancelet nearly all nerve cells contact the CSF, the CSF-contacting neurons represent a specialized, but phylogenetically old cell type, a "protoneuron" in the vertebrate brain. They may be derived phylogenetically by inversion of the ciliated neurons found in the plate-like nervous system of more primitive deuterostomians.

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Research works printed but not linked: 48

  1. Diepen, R.: Der Hypothalamus. In: (ed. by) W. Bargmann: Handbuch der mikroskopischen Anatomie des Menshen. Bd. IV/7. Springer, Berlin-Heidelberg, 1962.
  2. Meissl, H. and E. Dodt: Comparative physiology of pineal photoreceptor organs. In: (ed. by) A. Oksche and P. Pévet: The pineal organ. Photobiology-Biochronometry-Endocrinology (Developments in Endocrinology 14). Elsevier, Amsterdam-New York, 1981 (p. 61-81).
  3. Vigh, B. and I. Vigh-Teichmann: The cerebrospinal fluid-contacting neurosecretory cell: A protoneuron. In: (ed. by) D. S. Farner and K. Lederis: Neurosecretion: Molecules, cells, systems. Plenum Press, New York. 1982a. (p. 458-460).
  4. Vigh, B., I. Vigh-Teichmann and B. Aros: A present-day concept on the “neurosecretory neuron.” (In Hungarian). In: (ed. by) Gy. Csaba: A biológia aktuális problémai. Medicina, Budapest, 1976 (Vol. 7, p. 101-151).
  5. Vigh, B., I. Vigh-Teichmann and R. Olsson: Development of the medullo-spinal cerebrospinal fluid-contacting neurons. In: (ed. by) M. Spatz, B. B. Mrsulja, Lj. M. Rakic and W. D. Lust: Circulatory and developmental aspects of brain metabolism. Plenum Press, New York, 1980a. (p. 415-428).
  6. Vigh-Teichmann, I.: Comparative morphological studies on the relation between hypothalamic periventricular gray substance and cerebrospinal fluid. Thesis. Hung. Acad. Sci. Budapest 1971.
  7. Vinnikov, Y. A.: Sensory reception. Springer, Berlin, 1974.
  8. Horst‐W. Korf. Neuronal organization of the avian paraventricular nucleus: Intrinsic, afferent, and efferent connections. Journal of Experimental Zoology. 1984, Vol.232, No.3, p.387.
  9. I. Vigh‐Teichmann, H. Petter, B. Vigh. GABA‐immunoreactive intrinsic and ‐immunonegative secondary neurons in the cat pineal organ. Journal of Pineal Research. 1991, Vol.10, No.1, p.18.
  10. M. Isabel Rodriguez‐Moldes, Ramón Anadón. Ultrastructural Study of the Evolution of Globules in Coronet Cells of the Saccus Vasculosus of an Elasmobranch (Scyliorhinus canicula L.), with some Observations on Cerebrospinal Fluid‐Contacting Neurons. Acta Zoologica. 1988, Vol.69, No.4, p.217.
  11. Maria Soledad Ruiz, Ramón Anadon. Ultrastructural Study of the Filum Terminate and Caudal Ampulla of the Spinal Cord of Amphioxus (Branchiostoma lanceolatum Pallas). Acta Zoologica. 1991, Vol.72, No.2, p.63.
  12. Armando Menéndez, Manuel Alvarez-Uría. The dorso-lateral recess of the hypothalamic ventricle in neonatal rats. Cell & Tissue Research. 1987, Vol.250, No.1, p.197.
  13. Carlos R. Plata-Salamán. Insulin in the cerebrospinal fluid. Neuroscience & Biobehavioral Reviews. 1991, Vol.15, No.2, p.243.
  14. Christopher A. Lowry, Kathy A. Burke, Kenneth J. Renner, et al. Rapid Changes in Monoamine Levels Following Administration of Corticotropin-Releasing Factor or Corticosterone Are Localized in the Dorsomedial Hypothalamus. Hormones and Behavior. 2001, Vol.39, No.3, p.195.
  15. R.F. Alponti, J.M. Mancera, M.P. Martín-del-Río, et al. Galanin-like immunoreactivity in the brain of the snake Bothrops jararaca. General and Comparative Endocrinology. 2006, Vol.149, No.3, p.269.
  16. Ming Xiao, Jiong Ding, Lingxia Wu, et al. The distribution of neural nitric oxide synthase-positive cerebrospinal fluid-contacting neurons in the third ventricular wall of male rats and coexistence with vasopressin or oxytocin. Brain Research. 2005, Vol.1038, No.2, p.150.
  17. Robin A. Barraco, W. Richard Campbell, Eugene P. Schoener, et al. Cardiovascular effects of microinjections of adenosine analogs into the fourth ventricle of rats. Brain Research. 1987, Vol.424, No.1, p.17.
  18. J.A. Andrades, J. Becerra, P. Fernández-Llebrez. Skeletal deformities of the gilthead sea bream (Spams aurata, L.): Study of the subcommissural organ (SCO) and Reissner's fiber (RF). Annals of Anatomy - Anatomischer Anzeiger. 1994, Vol.176, No.4, p.381.
  19. Akira Chiba, Shunya Oka, Eiichi Saitoh. Ontogenetic changes in neuropeptide Y-immunoreactive cerebrospinal fluid-contacting neurons in the hypothalamus of the cloudy dogfish, Scyliorhinus torazame (Elasmobranchii). Neuroscience Letters. 2002, Vol.329, No.3, p.301.
  20. Madeline M. Weld, Leonard Maler. Substance P-like immunoreactivity in the brain of the gymnotiform fish Apteronotus leptorhynchus: Presence of sex differences. Journal of Chemical Neuroanatomy. 1992, Vol.5, No.2, p.107.
  21. G. Ramieri, G. C. Panzica. Comparative neuroanatomical aspects of the salt and water balance in birds and mammals. Journal of Endocrinological Investigation. 1989, Vol.12, No.1, p.59.
  22. Florian Razy-Krajka, Euan R Brown, Takeo Horie, et al. Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory. BMC Biology. 2012, Vol.10, No.1,
  23. G. Ju, S. Liu, J. Tao. Projections from the hypothalamus and its adjacent areas to the posterior pituitary in the rat. Neuroscience. 1986, Vol.19, No.3, p.803.
  24. Charles P Maurizi. The circulation and function of cerebrospinal fluid. Medical Hypotheses. 1984, Vol.15, No.2, p.155.
  25. Horacio J. Adrogué, Nicolaos E. Madias. Sodium surfeit and potassium deficit: Keys to the pathogenesis of hypertension. Journal of the American Society of Hypertension. 2014, Vol.8, No.3, p.203.
  26. Yusuke Nakane, Keisuke Ikegami, Masayuki Iigo, et al. The saccus vasculosus of fish is a sensor of seasonal changes in day length. Nature Communications. 2013, Vol.4, No.1,
  27. H Meissl, T Nakamura, G Thiele. Neural response mechanisms in the photoreceptive pineal organ of goldfish. Comparative Biochemistry and Physiology Part A Physiology. 1986, Vol.84, No.3, p.467.
  28. K.E. Miller, V.S. Seybold. Ultrastructure of the central gray region (lamina X) in cat spinal cord. Neuroscience. 1987, Vol.22, No.3, p.1057.
  29. Hernando Martínez Vergara, Paola Yanina Bertucci, Peter Hantz, et al. Whole-organism cellular gene-expression atlas reveals conserved cell types in the ventral nerve cord of Platynereis dumerilii . Proceedings of the National Academy of Sciences. 2017, Vol.114, No.23, p.5878.
  30. Wayne J. Kuenzel. Mapping the brain of the chicken (Gallus gallus), with emphasis on the septal-hypothalamic region. General and Comparative Endocrinology. 2018, Vol.256, p.4.
  31. Bing S. Huang, Roselyn A. White, Li Bi, et al. Central infusion of aliskiren prevents sympathetic hyperactivity and hypertension in Dahl salt-sensitive rats on high salt intake. AJP Regulatory Integrative and Comparative Physiology. 2012, Vol.302, No.7, p.R825.
  32. Alexander Gabor, Frans H. H. Leenen. Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats. AJP Regulatory Integrative and Comparative Physiology. 2009, Vol.296, No.3, p.R618.
  33. Marie‐Elisabeth Stoeckel, Sandra Uhl‐Bronner, Sylvain Hugel, et al. Cerebrospinal fluid‐contacting neurons in the rat spinal cord, a γ‐aminobutyric acidergic system expressing the P2X2 subunit of purinergic receptors, PSA‐NCAM, and GAP‐43 immunoreactivities: Light and electron microscopic study. The Journal of Comparative Neurology. 2003, Vol.457, No.2, p.159.
  34. Horst-W. Korf, Jan Fahrenkrug. Ependymal and neuronal specializations in the lateral ventricle of the Pekin duck, Anas platyrhynchos. Cell & Tissue Research. 1984, Vol.236, No.1, p.217.
  35. M. Olivereau, F. Ollevier, F. Vandesande, et al. Immunocytochemical identification of CRF-like and SRIF-like peptides in the brain and the pituitary of cyprinid fish. Cell & Tissue Research. 1984, Vol.237, No.2, p.379.
  36. Morten M�ller, Horst-Werner Korf. Neural connections between the brain and the pineal gland of the golden hamster (Mesocricetus auratus). Cell & Tissue Research. 1987, Vol.247, No.1, p.145.
  37. Akira Chiba, Shunya Oka, Yoshiharu Honma. Immunocytochemical distribution of FMRFamide-like substance in the brain of the cloudy dogfish, Scyliorhinus torazame. Cell & Tissue Research. 1991, Vol.265, No.2, p.243.
  38. Horst-W. Korf, Tetsuji Sato, Andreas Oksch. Complex relationships between the pineal organ and the medial habenular nucleus-pretectal region of the mouse as revealed by S-antigen immunocytochemistry. Cell & Tissue Research. 1990, Vol.261, No.3, p.493.
  39. Kanjun Hirunagi, Elke Rommel, Andreas Oksche, et al. Vasoactive intestinal peptide-immunoreactive cerebrospinal fluid-contacting neurons in the reptilian lateral septum nucleus accumbens. Cell & Tissue Research. 1993, Vol.274, No.1, p.79.
  40. Sanjay Dwivedi, P. D. Prasada Rao. Cytoarchitectonic pattern of the hypothalamus in the turtle, Lissemys punctata granosa. Cell & Tissue Research. 1992, Vol.270, No.1, p.173.
  41. 中根 右介, 池上 啓介, 飯郷 雅之ほか. Seasonal sensor in fish. Comparative Endocrinology. 2014, Vol.40, No.152, p.65.
  42. Akira Chiba, Yoshiharu Honma. The occurrence of the preoptic neurosecretory cells in the diencephalic ventricle of the arctic lamprey,Lampetra japonica . Japanese Journal of Ichthyology. 1989, Vol.35, No.4, p.488.
  43. Adeline Orts-Del’Immagine, Yasmine Cantaut-Belarif, Olivier Thouvenin, et al. Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo. Current Biology. 2020, Vol.30, No.5, p.827.
  44. I. Vigh-Teichmann, B. Vigh, A. Szél, et al. Immunocytochemical localization of Vitamin A in the retina and pineal organ of the frog,Rana esculenta. Histochemie. 1988, Vol.88, No.3-6, p.533.
  45. Donal C. Skinner, Donal C. Skinner. Gonadotropin-Releasing Hormone in Third Ventricular Cerebrospinal Fluid: Endogenous Distribution and Exogenous Uptake. Endocrinology. 2008, Vol.149, No.10, p.5227.
  46. Detlev Arendt. Elementary nervous systems. Philosophical Transactions Biological Sciences. 2021, Vol.376, No.1821,
  47. Alexey M. Olovnikov. Planetary Metronome as a Regulator of Lifespan and Aging Rate: The Metronomic Hypothesis. Biochemistry (Moscow). 2022, Vol.87, No.12-13, p.1640.
  48. Claire Wyart. Les neurones contactant le liquide cérébrospinal. Medecine sciences M/S. 2023, Vol.39, No.6-7, p.537.

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Authors
VIGH-TEICHMANN, I., & VIGH, B.
Affiliations
  • Second Department of Anatomy, Histology and Embryology, Semmelweis Medical University
  • Semmelweis University (HU)
Venue
Archivum histologicum japonicum
Publisher
International Society of Histology & Cytology
Published
1983
Volume
46
Issue
4
Pages
427-468
ISSN
0004-0681 (ISSN-L)
DOI
10.1679/aohc.46.427
OpenAlex
W2062150043
Cited by
195
References
102
Citations by year
2025: 1 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 12
FWCI
3.33
Type
journal article
Language
en
Open access
Locations
  • Archivum histologicum japonicum (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
cerebrospinal fluid-contacting neurons, hypothalamus, paraventricular organ, subcommissural organ, Reissner's fiber, kinocilium, stereocilia, ependyma, photoreceptors, pineal complex, retina, amphioxus, ciliated neurons
MeSH terms
Amphibians, Animals, Axons, Birds, Cerebral Ventricles, Cerebrospinal Fluid, Dendrites, Fishes, Hypothalamus, Microscopy, Electron, Nerve Endings, Neurons, Photoreceptor Cells, Pineal Gland, Reptiles, Spinal Cord, Subcommissural Organ

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