Randomized, controlled trial of topical exit-site application of honey (medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients
Abstract
The clinical usefulness of hemodialysis catheters is limited by increased infectious morbidity and mortality. Topical antiseptic agents, such as mupirocin, are effective at reducing this risk but have been reported to select for antibiotic-resistant strains. The aim of the present study was to determine the efficacy and the safety of exit-site application of a standardized antibacterial honey versus mupirocin in preventing catheter-associated infections. A randomized, controlled trial was performed comparing the effect of thrice-weekly exit-site application of Medihoney versus mupirocin on infection rates in patients who were receiving hemodialysis via tunneled, cuffed central venous catheters. A total of 101 patients were enrolled. The incidences of catheter-associated bacteremias in honey-treated (n = 51) and mupirocin-treated (n = 50) patients were comparable (0.97 versus 0.85 episodes per 1000 catheter-days, respectively; NS). On Cox proportional hazards model analysis, the use of honey was not significantly associated with bacteremia-free survival (unadjusted hazard ratio, 0.94; 95% confidence interval, 0.27 to 3.24; P = 0.92). No exit-site infections occurred. During the study period, 2% of staphylococcal isolates within the hospital were mupirocin resistant. Thrice-weekly application of standardized antibacterial honey to hemodialysis catheter exit sites was safe, cheap, and effective and resulted in a comparable rate of catheter-associated infection to that obtained with mupirocin (although the study was not adequately powered to assess therapeutic equivalence). The effectiveness of honey against antibiotic-resistant microorganisms and its low likelihood of selecting for further resistant strains suggest that this agent may represent a satisfactory alternative means of chemoprophylaxis in patients with central venous catheters.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prevention of exit site infection by coating catheters with honey was found to be at least as effective as povidone iodine or mupirocin.
“For example, prevention of exit site infection by coating catheters with honey was found to be at least as effective as povidone iodine [254] or mupirocin [255].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [255]
Cites
A Semiquantitative Culture Method for Identifying Intravenous-Catheter-Related Infection
Maki, D. G., Weise, C. E., & Sarafin, H. W. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706092962301 · Cited by 2,052 · see citing works
Kennedy, C. O. (1971) · British Homeopathic journal · doi:10.1016/s0007-0785(71)80027-3 · Cited by 976 · see citing works
Type of vascular access and mortality in U.S. hemodialysis patients
Dhingra, R. K., Young, E. W., Hulbert‐Shearon, T. E., Leavey, S. F., & Port, F. K. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00947.x · Cited by 760 · see citing works
Maki, D. G., Stolz, S. M., Wheeler, S., & Mermel, L. A. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-4-199708150-00001 · Cited by 748 · see citing works
Marr, K. A., Sexton, D. J., Conlon, P. J., Corey, G. R., Schwab, S. J., & Kirkland, K. B. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-4-199708150-00003 · Cited by 508 · see citing works
Honey stimulates inflammatory cytokine production from monocytes
Tonks, A. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00092-9 · Cited by 465 · see citing works
Vascular access and increased risk of death among hemodialysis patients
Pastan, S. O., Soucie, J. M., & McClellan, W. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00460.x · Cited by 451 · see citing works
Vascular Access and All-Cause Mortality
Polkinghorne, K. R., McDonald, S. P., Atkins, R. C., & Kerr, P. G. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000109668.05157.05 · Cited by 431 · see citing works
The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds
Cooper, R. A., Molan, P. C., & Harding, K. G. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01761.x · Cited by 416 · see citing works
Zumla, A. I., & LULAT, A. G. I. (1989) · Journal of the Royal Society of Medicine · doi:10.1177/014107688908200704 · Cited by 357 · see citing works
Antibacterial Activity of Honey against Strains of Staphylococcus Aureus from Infected Wounds
Cooper, R. A., Molan, P. C., & Harding, K. G. (1999) · Journal of the Royal Society of Medicine · doi:10.1177/014107689909200604 · Cited by 341 · see citing works
Potential of Honey in the Treatment of Wounds and Burns
Molan, P. C. (2001) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200102010-00003 · Cited by 333 · see citing works
Willix, D. J., Molan, P. C., & Harfoot, C. G. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04993.x · Cited by 275 · see citing works
Prospective Evaluation of a Dacron Cuffed Hemodialysis Catheter for Prolonged Use
Schwab, S. J., Buller, G. L., McCann, R. L., Bollinqer, R. R., & Stickel, D. L. (1988) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(88)80206-3 · Cited by 253 · see citing works
Systematic review of the use of honey as a wound dressing
Moore, O. A., Smith, L. A., Campbell, F. A., Seers, K., McQuay, H. J., & Moore, R. A. (2001) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-1-2 · Cited by 253 · see citing works
Flowers, R. H. (1989) · JAMA · doi:10.1001/jama.1989.03420060094039 · Cited by 245 · see citing works
The Efficacy of Honey in Inhibiting Strains of Pseudomonas Aeruginosa From Infected Burns
Cooper, R. A., Halas, E., & Molan, P. C. (2002) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-200211000-00002 · Cited by 228 · see citing works
Mupirocin-resistant Staphylococcus aureus
Cookson, B., Farrelly, H. D., PALEPOU, M.-F. I., & George, R. (1992) · The Lancet · doi:10.1016/0140-6736(92)90920-x · Cited by 197 · see citing works
EFFECT OF CATHETER TUNNELLING AND A NUTRITION NURSE ON CATHETER SEPSIS DURING PARENTERAL NUTRITION
Keohane, P. P., Attrill, H., Northover, J. M. A., Jones, B. J. M., Cribb, A. R., Frost, P., & Silk, D. B. A. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90922-4 · Cited by 184 · see citing works
The Effect of Gamma-irradiation on the Antibacterial Activity of Honey
Molan, P. C., & Allen, K. L. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb03922.x · Cited by 176 · see citing works
Fontán, M. P., Rosales, M., Rodríguez–Carmona, A., Falcón, T. G., & Valdés, F. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.30553 · Cited by 170 · see citing works
Johnson, D. W. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.10.1802 · Cited by 168 · see citing works
Self-citationAnnigeri, R. A., Conly, J. M., Vas, S. I., Dedier, H., Prakashan, K. P., Bargman, J. M., Jassal, V., & Oreopoulos, D. G. (2001) · Peritoneal Dialysis International · doi:10.1177/089686080102100604 · Cited by 160 · see citing works
Staphylococcus aureus prophylaxis in hemodialysis patients using central venous catheter
Sesso, R., Barbosa, D. A., Leme, I. L., Sader, H. S., Canziani, M. E. F., Manfredi, S. R., Draibe, S. A., & Pignatari, A. C. C. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v961085 · Cited by 157 · see citing works
The antimicrobial spectrum of honey and its clinical significance
Efem, S. E. E., & Iwara, C. I. (1992) · Infection · doi:10.1007/bf02033065 · Cited by 155 · see citing works
Interpretive criteria for testing susceptibility of staphylococci to mupirocin
Finlay, J., Miller, L. A., & Poupard, J. A. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.5.1137 · Cited by 135 · see citing works
Tunneling short-term central venous catheters to prevent catheter-related infection
Randolph, A. G., Cook, D. J., Gonzales, C. A., & Brun‐Buisson, C. (1998) · Critical Care Medicine · doi:10.1097/00003246-199808000-00038 · Cited by 127 · see citing works
SOURCE AND ROUTE OF MICROBIAL COLONISATION OF PARENTERAL NUTRITION CATHETERS
Cicco, M. D., Chiaradia, V., Veronesi, A., Santini, G., Panarello, G., Fracasso, A., Testa, V., & Tesio, F. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91861-8 · Cited by 101 · see citing works
Honey in the Management of Infections
Namias, N. (2003) · Surgical Infections · doi:10.1089/109629603766957022 · Cited by 88 · see citing works
Subrahmanyam, M. (1999) · Burns · doi:10.1016/s0305-4179(99)00063-7 · Cited by 87 · see citing works
Using honey as a dressing for infected skin lesions.
Dunford, C. E., Cooper, R., & Molan, P. C. (2000) · PubMed · Cited by 82 · see citing works
Lobbedez, T., Gardam, M. A., Dedier, H., Burdzy, D., Chu, M., Izatt, S., Bargman, J. M., Jassal, S. V., Vas, S. I., BRUNTON, J. L., et al. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh494 · Cited by 67 · see citing works
Venous access: a prospective, randomized study of the Hickman catheter.
Ld, W., Kirkemo, A., & Mr, J. (1984) · PubMed · Cited by 53 · see citing works
von Willebrand factor activity in primary and in scleroderma-associated Raynaud's phenomenon
Cuenca, R., Fernández-Cortijo, J., Fonollosa‐Pla, V., de Lima, J. N. G., Simeón‐Aznar, C. P., Vilardell, M., & Pico, M. (1990) · The Lancet · doi:10.1016/0140-6736(90)92666-6 · Cited by 45 · see citing works
Dixon, B. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00524-3 · Cited by 44 · see citing works
HONEY FOR NECROTIC BREAST ULCERS
Mossel, D. A. A. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92322-3 · Cited by 31 · see citing works
Vascular Access Use and Outcomes: Results from the DOPPS
Pisoni, R. L. (2002) · KARGER eBooks · doi:10.1159/000060262 · Cited by 29 · see citing works
Conly, J. M., & Vas, S. I. (2002) · Peritoneal Dialysis International · doi:10.1177/089686080202200601 · Cited by 23 · see citing works
Çavdar, C., Atay, T., Zeybel, M., Çelik, A., Özder, A., Yıldız, S., Gülay, Z., & Çamsarı, T. (2004) · PubMed · Cited by 19 · see citing works
Heitkemper, M. M. (1990) · Nutrition in Clinical Practice · doi:10.1177/088453369000500214 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update
Lok, C. E., Huber, T. S., Lee, T., Shenoy, S., Yevzlin, A. S., Abreo, K., Allon, M., Asif, A., Astor, B. C., Glickman, M. H., et al. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.12.001 · Cited by 2,590 · see citing works
Vatansever, F., Melo, W., Avci, P., Vecchio, D., Sadasivam, M., Gupta, A., Chandran, R., Karimi, M., Parizotto, N. A., Yin, R., et al. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12026 · Cited by 1,134 · see citing works
Honey as a topical treatment for wounds
Jull, A., Cullum, N. A., Dumville, J. C., Westby, M. J., Deshpande, S., & Walker, N. K. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005083.pub4 · Cited by 573 · see citing works
Traditional and modern uses of natural honey in human diseases: a review.
Eteraf-Oskouei, T., & Najafi, M. (2013) · Europe PMC (PubMed Central) · Cited by 456 · see citing works
The Evidence Supporting the Use of Honey as a Wound Dressing
Molan, P. C. (2006) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734605286014 · Cited by 446 · see citing works
Antibacterial components of honey
Kwakman, P. H. S., & Zaat, S. A. J. (2011) · IUBMB Life · doi:10.1002/iub.578 · Cited by 434 · see citing works
Alfei, S., Schito, G. C., Schito, A. M., & Zuccari, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137182 · Cited by 316 · see citing works
Current Management of Vascular Access
Allon, M. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00860207 · Cited by 286 · see citing works
Warady, B. A., Bakkaloglu, S. A., Newland, J. G., Cantwell, M., Verrina, E. E., Neu, A. M., Chadha, V., Yap, H., & Schaefer, F. S. (2012) · Peritoneal Dialysis International · doi:10.3747/pdi.2011.00091 · Cited by 270 · see citing works
Antimicrobial Properties of Honey
Israili, Z. H. (2013) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318293b09b · Cited by 238 · see citing works
Prevention and management of catheter-related infection in hemodialysis patients
Lok, C. E., & Mokrzycki, M. H. (2010) · Kidney International · doi:10.1038/ki.2010.471 · Cited by 236 · see citing works
Honey and Microbial Infections: A Review Supporting the Use of Honey for Microbial Control
Al-Waili, N. S. D., Salom, K., Butler, G. J., & Ghamdi, A. A. A. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0161 · Cited by 227 · see citing works
Medical Honey for Wound Care—Still the ‘Latest Resort’?
Simon, A., Traynor, K. S., Santos, K., Blaser, G., Bode, U., & Molan, P. C. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem175 · Cited by 223 · see citing works
Honey-Based Templates in Wound Healing and Tissue Engineering
Minden‐Birkenmaier, B. A., & Bowlin, G. L. (2018) · Bioengineering · doi:10.3390/bioengineering5020046 · Cited by 171 · see citing works
Honey has an antifungal effect against<i>Candida</i>species
Irish, J., Carter, D. A., Shokohi, T., & Blair, S. E. (2006) · Medical Mycology · doi:10.1080/13693780500417037 · Cited by 160 · see citing works
The impact of Manuka honey dressings on the surface pH of chronic wounds
Gethin, G., Cowman, S., & Conroy, R. M. (2008) · International Wound Journal · doi:10.1111/j.1742-481x.2007.00424.x · Cited by 159 · see citing works
RetractedHoney: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications
Mieles, J. Y., Vyas, C., Aslan, E., Humphreys, G. J., Diver, C., & Bártolo, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081663 · Cited by 156 · see citing works
Role of Honey in Advanced Wound Care
Scepankova, H., Combarros‐Fuertes, P., Fresno, J. M., Tornadijo, M. E., Sousa-Dias, M. L., Pinto, C. A., Saraiva, J. A., & Estevinho, L. M. (2021) · Molecules · doi:10.3390/molecules26164784 · Cited by 152 · see citing works
A systematic review of honey uses and its potential value within oncology care
Bardy, J., Slevin, N. J., Mais, K. L., & Molassiotis, A. (2008) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2008.02304.x · Cited by 141 · see citing works
Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?
Combarros‐Fuertes, P., Fresno, J. M., Estevinho, M. M., Sousa‐Pimenta, M., Tornadijo, M. E., & Estevinho, L. M. (2020) · Antibiotics · doi:10.3390/antibiotics9110774 · Cited by 139 · see citing works
Meta-analysis: Antibiotics for Prophylaxis against Hemodialysis Catheter–Related Infections
James, M. T., Conley, J., Tonelli, M. A., Manns, B., MacRae, J. M., Hemmelgarn, B. R., & for the Alberta Kidney Disease Network (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-8-200804150-00004 · Cited by 139 · see citing works
Merckoll, P., Jonassen, T. Ø., Vad, M. E., Jeansson, S. L., & Melby, K. K. (2009) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540902849383 · Cited by 138 · see citing works
Renal Association Clinical Practice Guideline on Vascular Access for Haemodialysis
Fluck, R., & Kumwenda, M. J. (2011) · Nephron Clinical Practice · doi:10.1159/000328071 · Cited by 136 · see citing works
Medical‐Grade Honey Kills Antibiotic‐Resistant Bacteria In Vitro and Eradicates Skin Colonization
Kwakman, P. H. S., van den Akker, J. P. C., Güçlü, A., Aslami, H., Binnekade, J. M., de Boer, L., Boszhard, L., Paulus, F., Middelhoek, P., Velde, A. A. T., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587892 · Cited by 135 · see citing works
Topical antibiotics for preventing surgical site infection in wounds healing by primary intention
Heal, C. F., Banks, J. L., Lepper, P. D., Kontopantelis, E., & van Driel, M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011426.pub2 · Cited by 131 · see citing works
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
Vanholder, R., Canaud, B., Fluck, R., Jadoul, M., Labriola, L., Marti-Monros, A., Tordoir, J., & Van Biesen, W. (2010) · Clinical Kidney Journal · doi:10.1093/ndtplus/sfq041 · Cited by 124 · see citing works
Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds
Alam, F., Islam, M. A., Gan, S. H., & Khalil, M. I. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/169130 · Cited by 124 · see citing works
Vascular Access–Related Infections: Definitions, Incidence Rates, and Risk Factors
Lafrance, J., Rahme, E., LeLorier, J., & Iqbal, S. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.06.014 · Cited by 124 · see citing works
Katneni, R., & Hedayati, S. S. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0447 · Cited by 121 · see citing works
Epidemiology, Surveillance, and Prevention of Bloodstream Infections in Hemodialysis Patients
Patel, P. R., Kallen, A. J., & Arduino, M. J. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.02.352 · Cited by 120 · see citing works
Honey: A Sweet Solution to the Growing Problem of Antimicrobial Resistance?
Maddocks, S., & Jenkins, R. (2013) · Future Microbiology · doi:10.2217/fmb.13.105 · Cited by 120 · see citing works
Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis
Fisher, M. C., Golestaneh, L., Allon, M., Abreo, K. D., & Mokrzycki, M. H. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06820619 · Cited by 118 · see citing works
Staphylococcus aureus Infections in Hemodialysis
Vandecasteele, S. J., Boelaert, J. R., & Vriese, A. S. D. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01590309 · Cited by 118 · see citing works
Honey as a topical treatment for wounds
Jull, A., Rodgers, A., & Walker, N. K. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005083.pub2 · Cited by 114 · see citing works
George, N., & CUTTING, K. F. (2007) · PubMed · Cited by 110 · see citing works
Honey as a topical treatment for wounds
Jull, A., Walker, N. K., & Deshpande, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005083.pub3 · Cited by 109 · see citing works
Wound care with antibacterial honey (Medihoney) in pediatric hematology–oncology
Simon, A., Sofka, K., Wiszniewsky, G., Blaser, G., Bode, U., & Fleischhack, G. (2005) · Supportive Care in Cancer · doi:10.1007/s00520-005-0874-8 · Cited by 99 · see citing works
Skin antisepsis for reducing central venous catheter-related infections
Lai, N. M., Lai, N. A., O'Riordan, E., Chaiyakunapruk, N., Taylor, J. E., & Tan, K. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010140.pub2 · Cited by 98 · see citing works
McCann, M., & Moore, Z. E. H. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006894.pub2 · Cited by 97 · see citing works
Staphylococcal decolonisation: an effective strategy for prevention of infection?
Simor, A. E. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70281-x · Cited by 92 · see citing works
Agents for the Decolonization of Methicillin‐Resistant Staphylococcus aureus
McConeghy, K. W., Mikolich, D. J., & LaPlante, K. L. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.3.263 · Cited by 91 · see citing works
Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy.
Wijesinghe, M., Weatherall, M., Perrin, K., & Beasley, R. W. (2009) · PubMed · Cited by 89 · see citing works
Johnson, D. W., Badve, S. V., Pascoe, E. M., Beller, E., Cass, A., Clark, C. J., de Zoysa, J., Isbel, N. M., McTaggart, S. J., Morrish, A. T., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70258-5 · Cited by 89 · see citing works
Self-citationHoney-Based Medicinal Formulations: A Critical Review
Hossain, M. L., Lim, L. Y., Hammer, K. A., Hettiarachchi, D. S., & Locher, C. (2021) · Applied Sciences · doi:10.3390/app11115159 · Cited by 81 · see citing works
Systematic review of antimicrobials for the prevention of haemodialysis catheter-related infections
Rabindranath, K. S., Bansal, T., Adams, J., Das, R., Shail, R., MacLeod, A. M., Moore, C. L., & Besarab, A. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp327 · Cited by 76 · see citing works
Prevention of catheter-related bloodstream infection in patients on hemodialysis
Betjes, M. G. H. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.28 · Cited by 69 · see citing works
Honey Authentication: A review of the issues and challenges associated with honey adulteration
Bose, D., & Manchikanti, P. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105004 · Cited by 68 · see citing works
Broom, J. K., Krishnasamy, R., Hawley, C. M., Playford, E. G., & Johnson, D. W. (2012) · BMC Nephrology · doi:10.1186/1471-2369-13-146 · Cited by 63 · see citing works
Self-citationPhytochemistry, metabolism, and ethnomedical scenario of honey: A concurrent review
Ahmad, R. S., Hussain, M. B., Saeed, F., Waheed, M., & Tufail, T. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1295257 · Cited by 60 · see citing works
Prevention of peritoneal dialysis-related infections
Campbell, D. J., Johnson, D. W., Mudge, D. W., Gallagher, M., & Craig, J. C. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu313 · Cited by 59 · see citing works
Self-citationInvestigation of in vitro antifungal activity of honey
Anyanwu, C. U. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.577 · Cited by 55 · see citing works
Antimicrobial approaches in the prevention ofStaphylococcus aureusinfections: a review
Troeman, D. P. R., van Hout, D., & Kluytmans, J. A. J. W. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky421 · Cited by 54 · see citing works
Battistella, M., Bhola, C., & Lok, C. E. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.10.009 · Cited by 50 · see citing works
Wasfi, R., Elkhatib, W. F., & Khairalla, A. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150984 · Cited by 49 · see citing works
Maintaining Safety in the Dialysis Facility
Kliger, A. S. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08960914 · Cited by 46 · see citing works
Vascular access in therapeutic apheresis: Update 2013
Golestaneh, L., & Mokrzycki, M. H. (2013) · Journal of Clinical Apheresis · doi:10.1002/jca.21267 · Cited by 45 · see citing works
Golestaneh, L., & Mokrzycki, M. H. (2018) · Hemodialysis International · doi:10.1111/hdi.12703 · Cited by 43 · see citing works
Management of Gram-Positive Coccal Bacteremia and Hemodialysis
Fitzgibbons, L. N., Puls, D. L., MacKay, K., & Forrest, G. N. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.12.013 · Cited by 41 · see citing works
Robson, V., Yorke, J., Sen, R. A., Lowe, D., & Rogers, S. N. (2011) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.bjoms.2011.07.014 · Cited by 40 · see citing works
Prevention and Treatment of Hemodialysis‐Related Bloodstream Infections
Camins, B. C. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12117 · Cited by 40 · see citing works
The Economics of Hemodialysis Catheter‐Related Infection Prophylaxis
Kosa, S. D., & Lok, C. E. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12115 · Cited by 40 · see citing works
Camins, B. C., Richmond, A. M., Dyer, K. L., Zimmerman, H. N., Coyne, D. W., Rothstein, M., & Fraser, V. J. (2010) · Infection Control and Hospital Epidemiology · doi:10.1086/657075 · Cited by 38 · see citing works
Yang, M., Ward, J. M., & Choy, K. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.202000070 · Cited by 37 · see citing works
Prevention of Central Line–Associated Bloodstream Infections in Hemodialysis Patients
Boyce, J. M. (2012) · Infection Control and Hospital Epidemiology · doi:10.1086/667369 · Cited by 34 · see citing works
Bell, S. G. (2007) · Neonatal Network The Journal of Neonatal Nursing · doi:10.1891/0730-0832.26.4.247 · Cited by 34 · see citing works
Cooper, R. (2014) · Chronic Wound Care Management and Research · doi:10.2147/cwcmr.s46520 · Cited by 32 · see citing works
Novel Therapies for Biofilm-Based Candida spp. Infections
Černáková, L., Light, C. J., Salehi, B., Rogel-Castillo, C., Victoriano, M., Martorell, M., Sharifi‐Rad, J., Martins, N. A., & Rodrigues, C. F. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_400 · Cited by 32 · see citing works
Prevention of access-related infection in dialysis
Barraclough, K. A., Hawley, C. M., Playford, E. G., & Johnson, D. W. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.100 · Cited by 31 · see citing works
Self-citationPrevention Of Peritoneal Dialysis–Related Infections
Nessim, S. J. (2011) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2011.01.008 · Cited by 30 · see citing works
Preventing infections in patients undergoing hemodialysis
Kallen, A. J., Arduino, M. J., & Patel, P. R. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.47 · Cited by 30 · see citing works
Honey: Antimicrobial Actions and Role in Disease Management
Molan, P. C. (2008) · Wiley eBooks · doi:10.1002/9783527622931.ch9 · Cited by 30 · see citing works
Assessing the quality of bee honey on the basis of melissopalynology as well as chemical analysis
Shakoori, Z., Mehrabian, A., Minai, D., Salmanpour, F., & Nasab, F. K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289702 · Cited by 29 · see citing works
Johnson, D. W., Clark, C. J., Isbel, N. M., Hawley, C. M., Beller, E., Cass, A., de Zoysa, J., McTaggart, S. J., Playford, E. G., Rosser, B., et al. (2009) · Peritoneal Dialysis International · doi:10.1177/089686080902900315 · Cited by 29 · see citing works
Self-citationLok, C. E. (2006) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2006.04.009 · Cited by 28 · see citing works
Vercaigne, L. M., Allan, D. R., Armstrong, S. W., Zacharias, J., & Miller, L. (2015) · The Journal of Vascular Access · doi:10.5301/jva.5000486 · Cited by 27 · see citing works
Beyond Pollination: Honey Bees (Apis mellifera) as Zootherapy Keystone Species
Easton‐Calabria, A., Demary, K. C., & Oner, N. J. (2019) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00161 · Cited by 26 · see citing works
Righetti, M., Palmieri, N., Bracchi, O., Prencipe, M., Bruschetta, E., Colombo, F., Brenna, I., Stefani, F., Amar, K., Scalia, A., et al. (2016) · The Journal of Vascular Access · doi:10.5301/jva.5000596 · Cited by 24 · see citing works
Magdas, T. M., David, M., Hategan, A. R., Filip, G. A., & Măgdaş, D. A. (2024) · Foods · doi:10.3390/foods13040532 · Cited by 24 · see citing works
Kwakman, P. H. S., Müller, M. C. A., Binnekade, J. M., van den Akker, J. P. C., de Borgie, C. A. J. M., Schultz, M. J., & Zaat, S. A. J. (2012) · Critical Care · doi:10.1186/cc11849 · Cited by 24 · see citing works
Antibacterial activity of selected Portuguese honeys
Henriques, A., Burton, N. F., & Cooper, R. A. (2005) · Journal of Apicultural Research · doi:10.1080/00218839.2005.11101161 · Cited by 22 · see citing works
Broom, J. K., O’Shea, S., Govindarajulu, S., Playford, E. G., Hawley, C. M., Isbel, N. M., Campbell, S. B., Mudge, D. W., Carpenter, S., Johnson, B. C., et al. (2009) · BMC Nephrology · doi:10.1186/1471-2369-10-23 · Cited by 21 · see citing works
Self-citationReducing Catheter-Related Infections in Hemodialysis Patients
Landry, D. L., & Braden, G. L. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04700514 · Cited by 21 · see citing works
Infections of Intravascular Catheters and Vascular Devices
Yanagi, H., & Sherertz, R. J. (2009) · Wiley eBooks · doi:10.1002/9781444308464.ch18 · Cited by 20 · see citing works
Najafi, M., Shaseb, E., Ghaffary, S., Fakhrju, A., & Eteraf-Oskouei, T. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 18 · see citing works
Nishio, E. K., Bodnar, G. C., Perugini, M. R. E., Andrei, C. C., Proní, E. A., Kobayashi, R. K. T., & Nakazato, G. (2015) · Journal of Apicultural Research · doi:10.1080/00218839.2016.1162985 · Cited by 17 · see citing works
Kallen, A. J., Jernigan, J. A., & Patel, P. R. (2011) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2011.00959.x · Cited by 17 · see citing works
Traditional Knowledge of Stingless Bees (Hymenoptera: Apidae: Meliponini) in the Peruvian Amazon
Delgado, C., Mejía, K., Rasmussen, C., & Romero, R. (2023) · Ethnobiology Letters · doi:10.14237/ebl.14.1.2023.1772 · Cited by 16 · see citing works
Zhang, L., Badve, S. V., Pascoe, E. M., Beller, E., Cass, A., Clark, C. J., de Zoysa, J., Isbel, N. M., McTaggart, S. J., Morrish, A. T., et al. (2015) · Peritoneal Dialysis International · doi:10.3747/pdi.2014.00206 · Cited by 16 · see citing works
Self-citationBose, D., Famurewa, A. C., Akash, A., & Othman, E. M. (2024) · Journal of Xenobiotics · doi:10.3390/jox14030063 · Cited by 15 · see citing works
Therapeutic properties of honey
Pipicelli, G., & Tatti, P. (2009) · Health · doi:10.4236/health.2009.14045 · Cited by 15 · see citing works
Padilla‐Orozco, M., Mendoza‐Flores, L., Herrera-Alonso, A., Garza‐González, E., Gutiérrez-Ferman, J. L., Rodríguez-López, J. M., Bocanegra‐Ibarias, P., & Camacho-Ortíz, A. (2019) · The Nephron journals/Nephron journals · doi:10.1159/000500549 · Cited by 13 · see citing works
Lafrance, J., Iqbal, S., LeLorier, J., Dasgupta, K., Ritchie, J., Ward, L. M., Benaroya, S., Barré, P. E., Cantarovich, M., Ghannoum, M., et al. (2009) · Nephron Clinical Practice · doi:10.1159/000262303 · Cited by 11 · see citing works
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects
Sinha, S., Sehgal, A., Ray, S., & Sehgal, R. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230605120717 · Cited by 10 · see citing works
The modern use of honey in the treatment of wounds
Cooper, R. (2005) · Bee World · doi:10.1080/0005772x.2005.11417325 · Cited by 10 · see citing works
Medihoney™: a complete wound bed preparation product
Acton, C. (2008) · British Journal of Nursing · doi:10.12968/bjon.2008.17.sup5.29651 · Cited by 10 · see citing works
Delgado, C., & Espinoza, R. V. (2023) · Food and Humanity · doi:10.1016/j.foohum.2023.08.017 · Cited by 9 · see citing works
Bogdanov, S. (2012) · Cited by 9 · see citing works
Honey in the Prevention and Treatment of Infection in the CKD Population: A Narrative Review
Francis, A., Cho, Y., & Johnson, D. W. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/261425 · Cited by 9 · see citing works
Self-citationNajafi, M., Aghdam, E. M., Farzaneh, R., & Eteraf-Oskouei, T. (2008) · Cited by 9 · see citing works
- Authors
- Johnson, D. W., van Eps, C., Mudge, D. W., Wiggins, K. J., Armstrong, K., Hawley, C. M., Campbell, S. B., Isbel, N. M., Nimmo, G. R., & Gibbs, H.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Johnson, David Wayne
- ORCID
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-05
- Volume
- 16
- Issue
- 5
- Pages
- 1456-1462
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2139683791
- Cited by
- 162
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Smith and Nephew
- Topics
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Keywords
- honey, mupirocin, catheter exit site infection, catheter-related bacteremia, hemodialysis catheter, central venous catheters, antibiotic resistance, topical antibiotics, infection control, staphylococcal isolates
- MeSH terms
- Adult, Aged, Anti-Bacterial Agents, Bandages, Catheterization, Central Venous, Female, Renal Dialysis, Honey, Humans, Kidney Failure, Chronic, Male, Middle Aged, Risk Factors, Bacteremia, Drug Costs, Mupirocin, Disease-Free Survival
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
