The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Effectiveness of Vasopressin V2 Receptor Antagonists OPC-31260 and OPC-41061 on Polycystic Kidney Disease Development in the PCK Rat
Abstract
cAMP plays a major role in cystogenesis. Recent in vitro studies suggested that cAMP stimulates B-Raf/ERK activation and proliferation of cyst-derived cells in a Ca(2+) inhibitable, Ras-dependent manner. OPC-31260, a vasopressin V2 receptor (VPV2) antagonist, was shown to lower renal cAMP and inhibit renal disease development and progression in models orthologous to human cystic diseases. Here it is shown that OPC-41061, an antagonist chosen for its potency and selectivity for human VPV2, is effective in PCK rats. PCK kidneys have increased Ras-GTP and phosphorylated ERK levels and 95-kD/68-kD B-Raf ratios, changes that are corrected by the administration of OPC-31260 or OPC-41061. These results support the importance of cAMP in the pathogenesis of polycystic kidney disease, confirm the effectiveness of a VPV2 antagonist to be used in clinical trials for this disease, and suggest that OPC-31260 and OPC-41061 inhibit Ras/mitogen-activated protein kinase signaling in polycystic kidneys.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ward, C. J., Hogan, M. C., Rossetti, S., Walker, D., Sneddon, T., Wang, X., Kubly, V., Cunningham, J. M., Bacallao, R., Ishibashi, M., et al. (2002) · Nature Genetics · doi:10.1038/ng833 · Cited by 765
Self-citationGattone, V. H., Wang, X., Harris, P. C., & Torres, V. E. (2003) · Nature Medicine · doi:10.1038/nm935 · Cited by 670
Self-citationGheorghiade, M. (2004) · JAMA · doi:10.1001/jama.291.16.1963 · Cited by 651
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Torres, V. E., Wang, X., Qian, Q., Somlo, S., Harris, P. C., & Gattone, V. H. (2004) · Nature Medicine · doi:10.1038/nm1004 · Cited by 482
Self-citationYamaguchi, T., Wallace, D. P., Magenheimer, B. S., Hempson, S. J., Grantham, J. J., & Calvet, J. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405079200 · Cited by 353
Yamamura, Y., Nakamura, S., Itoh, S., Hirano, T., Onogawa, T., Yamashita, T., Yamada, Y., Tsujimae, K., Aoyama, M., Kotosai, K., et al. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37873-5 · Cited by 337
Bankir, L. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00328-5 · Cited by 300
Yamaguchi, T., Nagao, S., Kasahara, M., Takahashi, H., & Grantham, J. J. (1997) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(97)90496-0 · Cited by 141
Gattone, V. H., Maser, R. L., Tian, C., Rosenberg, J. M., & Branden, M. G. (1999) · Developmental Genetics · Cited by 141
Self-citationFujita, T., Meguro, T., Fukuyama, R., Nakamuta, H., & Koida, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110364200 · Cited by 116
Cited by
Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Self-citationInsufficient Sleep in Adolescents and Young Adults: An Update on Causes and Consequences
Owens, J., ADOLESCENT SLEEP WORKING GROUP, COMMITTEE ON ADOLESCENCE, Au, R., Carskadon, M., Millman, R., Wolfson, A., Braverman, P. K., Adelman, W. P., Breuner, C. C., et al. (2014) · Pediatrics · doi:10.1542/peds.2014-1696 · Cited by 1,413
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
Torres, V. E., Chapman, A. B., Devuyst, O., Gansevoort, R. T., Perrone, R. D., Koch, G., Ouyang, J., McQuade, R. D., Blais, J. D., Czerwiec, F. S., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1710030 · Cited by 639
Self-citationMechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases
Torres, V. E., & Harris, P. C. (2006) · Nature Clinical Practice Nephrology · doi:10.1038/ncpneph0070 · Cited by 296
Self-citationProgress and prospects in rat genetics: a community view
Aitman, T. J., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., Gauguier, D., Geurts, A. M., Gould, M., Harris, P. C., et al. (2008) · Nature Genetics · doi:10.1038/ng.147 · Cited by 291
Self-citation
Metadata
- Authors
- Wang, X., Gattone, V., Harris, P. C., & Torres, V. E.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-04
- Volume
- 16
- Issue
- 4
- Pages
- 846-851
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2103621765
- Cited by
- 334
- References
- 12
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effectiveness of Vasopressin V2 Receptor Antagonists OPC-31260 and OPC-41061 on Polycystic Kidney Disease Development in the PCK Rat. https://app.cochat.ai/papers/10.1681/asn.2004121090
- The paper
- Wang, X., Gattone, V., Harris, P. C., & Torres, V. E. (2005). Effectiveness of Vasopressin V2 Receptor Antagonists OPC-31260 and OPC-41061 on Polycystic Kidney Disease Development in the PCK Rat. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2004121090
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
