Progress and prospects in rat genetics: a community view
Abstract
The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.
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With advancements in rat genetic modification technologies, it is now possible to create rat models of senescent cell clearance.
“With advancements in genetic modification technologies in the rat [47–51], it is now possible to create rat models of senescent cell clearance.”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [47]
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- Authors
- Aitman, T. J., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., Gauguier, D., Geurts, A. M., Gould, M., Harris, P. C., Holmdahl, R., Hubner, N., Izsvák, Z., Jacob, H. J., Kuramoto, T., Kwitek, A. E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J. D., Szpirer, C., Twigger, S. N., Voigt, B., & Worley, K.
- Affiliations
- Imperial College London (GB)
- University of Missouri (US)
- Hubrecht Institute for Developmental Biology and Stem Cell Research (NL)
- University of Glasgow (GB)
- Centre for Human Genetics (GB)
- Medical College of Wisconsin (US)
- University of Wisconsin–Madison (US)
- Mayo Clinic (US)
- Karolinska Institutet (SE)
- Max Delbrück Center (DE)
- Kyoto University (JP)
- University of Iowa (US)
- University of Edinburgh (GB)
- Czech Academy of Sciences (CZ)
- University of Nebraska Medical Center (US)
- Université Libre de Bruxelles (BE)
- Baylor College of Medicine (US)
- Corresponding author
- Aitman, Timothy J
- Jacob, Howard J
- ORCID
- Aitman, Timothy J
- Cuppen, Edwin
- Dominiczak, Anna
- Gauguier, Dominique
- Geurts, Aron M
- Harris, Peter C
- Holmdahl, Rikard
- Izsvák, Zsuzsanna
- Jacob, Howard J
- Kuramoto, Takashi
- Kwitek, Anne E
- Mashimo, Tomoji
- Mullins, John
- Mullins, Linda
- Olsson, Tomas
- Pravenec, Michal
- Saar, Kathrin
- Shull, James D
- Szpirer, Claude
- Twigger, Simon N
- Worley, Kim
- Venue
- Nature Genetics
- Published
- 2008-04-28
- Volume
- 40
- Issue
- 5
- Pages
- 516-522
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2100353278
- Cited by
- 291
- References
- 82
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 22 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 20
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- National Cancer Institute (R01CA077876)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK059597)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- rat genetics, disease gene discovery, genome-wide association study, gene pathways, translational research
- MeSH terms
- Animals, Chromosome Mapping, Disease Models, Animal, Humans, Genome, Gene Targeting, Genomics, Genetic Diseases, Inborn, Animals, Genetically Modified, Rats
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