The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure
Abstract
Endothelial dysfunction and arterial stiffness are major determinants of cardiovascular risk in patients with end-stage renal failure (ESRF). Microparticles are membrane fragments shed from damaged or activated cells. Because microparticles can affect endothelial cells, this study investigated the relationship between circulating microparticles and arterial dysfunction in patients with ESRF and identified the cellular origin of microparticles associated with these alterations. Flow cytometry analysis of platelet-free plasma from 44 patients with ESRF indicated that circulating levels of Annexin V+ microparticles were increased compared with 32 healthy subjects, as were levels of microparticles derived from endothelial cells (three-fold), platelets (16.5-fold), and erythrocytes (1.6-fold). However, when arterial function was evaluated noninvasively in patients with ESRF, only endothelial microparticle levels correlated highly with loss of flow-mediated dilation (r = -0.543; P = 0.004), increased aortic pulse wave velocity (r = 0.642, P < 0.0001), and increased common carotid artery augmentation index (r = 0.463, P = 0.0017), whereas platelet-derived, erythrocyte-derived, and Annexin V+ microparticle levels did not. In vitro, microparticles from patients with ESRF impaired endothelium-dependent relaxations and cyclic guanosine monophosphate generation, whereas microparticles from healthy subjects did not. Moreover, in vitro endothelial dysfunction correlated with endothelial-derived (r = 0.891; P = 0.003) but not platelet-derived microparticle concentrations. In fact, endothelial microparticles alone decreased endothelial nitric oxide release by 59 +/- 7% (P = 0.025). This study suggests that circulating microparticles of endothelial origin are tightly associated with endothelial dysfunction and arterial dysfunction in ESRF.
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Cites
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., & Hsu, C.-Y. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041031 · Cited by 11,369
Clinical epidemiology of cardiovascular disease in chronic renal disease
Foley, R., Parfrey, P., & Sarnak, M. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9820470 · Cited by 3,958
Endothelial Dysfunction: A Marker of Atherosclerotic Risk
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Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
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Aortic pulse wave velocity index and mortality in end-stage renal disease
Blacher, J., Safar, M. E., Guerin, A. P., Pannier, B., Marchais, S. J., & London, G. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00932.x · Cited by 532
Self-citationCirculating Microparticles From Patients With Myocardial Infarction Cause Endothelial Dysfunction
Boulanger, C. M., Scoazec, A., Ebrahimian, T., Henry, P., Mathieu, E., Tedgui, A., & Mallat, Z. (2001) · Circulation · doi:10.1161/hc4701.100516 · Cited by 510
Self-citationEffects of Severe Hypertension on Endothelial and Platelet Microparticles
Preston, R. A., Jy, W., Jimenez, J. J., Mauro, L. M., Horstman, L. L., Valle, M., Aime, G., & Ahn, Y. S. (2003) · Hypertension · doi:10.1161/01.hyp.0000049760.15764.2d · Cited by 499
Cardiac and arterial interactions in end-stage renal disease
London, G. M., Guerin, A. P., Marchais, S. J., Pannier, B., Safar, M. E., Day, M., & Metivier, F. (1996) · Kidney International · doi:10.1038/ki.1996.355 · Cited by 474
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Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, É., Pap, E., Kittel, Á., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0689-3 · Cited by 2,074
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818
The Gut Microbiome, Kidney Disease, and Targeted Interventions
Ramezani, A., & Raj, D. S. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080905 · Cited by 743
Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction
Zampetaki, A., Willeit, P., Tilling, L., Drozdov, I., Prokopi, M., Renard, J.-M., Mayr, A., Weger, S., Schett, G., Shah, A., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.056 · Cited by 464
Self-citationEndothelial microparticles in diseases
Chironi, G. N., Boulanger, C. M., Simon, A., Dignat-George, F., Freyssinet, J.-M., & Tedgui, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0710-9 · Cited by 420
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Metadata
- Authors
- Amabile, N., Guérin, A. P., Leroyer, A., Mallat, Z., Nguyen, C., Boddaert, J., London, G. M., Tedgui, A., & Boulanger, C. M.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-11
- Volume
- 16
- Issue
- 11
- Pages
- 3381-3388
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2137742067
- Cited by
- 552
- References
- 28
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amabile, N., Guérin, A. P., Leroyer, A., Mallat, Z., Nguyen, C., Boddaert, J., London, G. M., Tedgui, A., & Boulanger, C. M. (2005). Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2005050535
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