The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Endothelin System and Its Antagonism in Chronic Kidney Disease
Abstract
The incidence of chronic kidney disease (CKD) is increasing worldwide. Cardiovascular disease (CVD) is strongly associated with CKD and constitutes one of its major causes of morbidity and mortality. Treatments that slow the progression of CKD and improve the cardiovascular risk profile of patients with CKD are needed. The endothelins (ET) are a family of related peptides, of which ET-1 is the most powerful endogenous vasoconstrictor and the predominant isoform in the cardiovascular and renal systems. The ET system has been widely implicated in both CVD and CKD. ET-1 contributes to the pathogenesis and maintenance of hypertension and arterial stiffness and more novel cardiovascular risk factors such as oxidative stress and inflammation. Through these, ET also contributes to endothelial dysfunction and atherosclerosis. By reversal of these effects, ET antagonists may reduce cardiovascular risk. In particular relation to the kidney, antagonism of the ET system may be of benefit in improving renal hemodynamics and reducing proteinuria. ET likely also is involved in progression of renal disease, and data are emerging to suggest a synergistic role for ET receptor antagonists with angiotensin-converting enzyme inhibitors in slowing CKD progression.
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The L-Arginine-Nitric Oxide Pathway
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Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
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Cited by
Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
Self-citationAssociation Between Sleep Apnea and Blood Pressure Control Among Blacks: Jackson Heart Sleep Study
Johnson, D. A., Thomas, S. J., Abdalla, M., Guo, N., Yano, Y., Rueschman, M., Tanner, R. M., Mittleman, M. A., Calhoun, D. A., Wilson, J. G., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.036675 · Cited by 81
Dhaun, N., Moorhouse, R., MacIntyre, I. M., Melville, V., Oosthuyzen, W., Kimmitt, R. A., Brown, K. E., Kennedy, E. D., Goddard, J., & Webb, D. J. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03533 · Cited by 54
Self-citationLinking chronic kidney disease and Parkinson’s disease: a literature review
Meléndez-Flores, J. D., & Estrada-Bellmann, I. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00623-1 · Cited by 44
Metadata
- Authors
- Dhaun, N., Goddard, J., & Webb, D.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2006-04
- Volume
- 17
- Issue
- 4
- Pages
- 943-955
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2163370089
- Cited by
- 256
- References
- 3
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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