The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Role of Altered Renal Lipid Metabolism in the Development of Renal Injury Induced by a High-Fat Diet
Open accessAbstract
Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal injury in patients with metabolic syndrome may be a result of altered renal lipid metabolism. We fed wild-type or insulin-sensitive heterozygous peroxisome proliferator-activated receptor gamma-deficient (PPARgamma(+/-)) mice a high-fat diet for 16 weeks. In wild-type mice, this diet induced core features of metabolic syndrome, subsequent renal lipid accumulation, and renal injury including glomerulosclerosis, interstitial fibrosis, and albuminuria. Renal lipogenesis accelerated, determined by increased renal mRNA expression of the lipogenic enzymes fatty acid synthase and acetyl-CoA carboxylase (ACC) and by increased ACC activity. In addition, renal lipolysis was suppressed, determined by reduced mRNA expression of the lipolytic enzyme carnitine palmitoyl acyl-CoA transferase 1 and by reduced activity of AMP-activated protein kinase. In PPARgamma(+/-) mice, renal injury, systemic metabolic abnormalities, renal accumulation of lipids, and the changes in renal lipid metabolism were attenuated. Thus, a high-fat diet leads to an altered balance between renal lipogenesis and lipolysis, subsequent renal accumulation of lipid, and renal injury. We suggest that renal lipid metabolism could serve as a new therapeutic target to prevent chronic kidney disease in patients with metabolic syndrome.
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487
The SREBP pathway — insights from insigs and insects
Rawson, R. B. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1174 · Cited by 323
Cited by
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D'Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman-Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 716
Kume, S., Uzu, T., Horiike, K., Chin-Kanasaki, M., Isshiki, K., Araki, S.-I., Sugimoto, T., Haneda, M., Kashiwagi, A., & Koya, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41376 · Cited by 640
Self-citationRenal lipid metabolism and lipotoxicity
Bobulescu, I. A. (2010) · Current Opinion in Nephrology and Hypertension · doi:10.1097/mnh.0b013e32833aa4ac · Cited by 364
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Sun, Y., Ge, X., Li, X., He, J., Wei, X., Du, J., Sun, J., Li, X., Xun, Z., Liu, W., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03122-4 · Cited by 328
Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy
Tagawa, A., Yasuda, M., Kume, S., Yamahara, K., Nakazawa, J., Chin-Kanasaki, M., Araki, H., Araki, S.-I., Koya, D., Asanuma, K., et al. (2016) · Diabetes · doi:10.2337/db15-0473 · Cited by 315
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Metadata
- Authors
- Kume, S., Uzu, T., Araki, S.-I., Sugimoto, T., Isshiki, K., Chin-Kanasaki, M., Sakaguchi, M., Kubota, N., Terauchi, Y., Kadowaki, T., Haneda, M., Kashiwagi, A., & Koya, D.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2007-10
- Volume
- 18
- Issue
- 10
- Pages
- 2715-2723
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2155155293
- Cited by
- 278
- References
- 7
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kume, S., Uzu, T., Araki, S.-I., Sugimoto, T., Isshiki, K., Chin-Kanasaki, M., Sakaguchi, M., Kubota, N., Terauchi, Y., Kadowaki, T., Haneda, M., Kashiwagi, A., & Koya, D. (2007). Role of Altered Renal Lipid Metabolism in the Development of Renal Injury Induced by a High-Fat Diet. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2007010089
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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