The SREBP pathway — insights from insigs and insects
Abstract
Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role for the SREBP pathway in integrating membrane composition and lipid biosynthesis.
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SREBP in flies regulates fatty acid metabolism.
“SREBP in flies regulates fatty acid metabolism (16), which is reminiscent of the function of the Srebp-1 gene in mammals (6).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [16]
Cites
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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
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Self-citationThe SREBP Pathway in Drosophila
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Self-citationJanowski, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202471599 · Cited by 79 · see citing works
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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
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- Authors
- Rawson, R. B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Rawson, Robert B.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2003-08-01
- Volume
- 4
- Issue
- 8
- Pages
- 631-640
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1591850964
- Cited by
- 323
- References
- 4
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 20 · 2014: 12 · 2013: 10 · 2012: 12
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- SREBP pathway, SREBP, lipid homeostasis, membrane composition, lipogenesis, Drosophila, insects, transcriptional regulation
- MeSH terms
- Animals, Cell Membrane, DNA-Binding Proteins, Humans, Lipids, Membrane Proteins, Metalloendopeptidases, Sterols, Transcription Factors, Molecular Structure, Insect Proteins, CCAAT-Enhancer-Binding Proteins, Intracellular Signaling Peptides and Proteins, Lipid Metabolism, Sterol Regulatory Element Binding Protein 1
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