The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease
Open accessAbstract
The polycystic kidney diseases (PKD) are a group of genetic disorders causing renal failure and death from infancy to adulthood. Arginine vasopressin (AVP) V2 receptor antagonists inhibit cystogenesis in animal models of cystic kidney diseases, presumably by downregulating cAMP signaling, cell proliferation, and chloride-driven fluid secretion. For confirmation that the protective effect of these drugs is due to antagonism of AVP, PCK (Pkhd1(-/-)) and Brattleboro (AVP(-/-)) rats were crossed to generate rats with PKD and varying amounts of AVP. At 10 and 20 weeks of age, PCK AVP(-/-) rats had lower renal cAMP and almost complete inhibition of cystogenesis compared with PCK AVP(+/+) and PCK AVP(+/-) rats. The V2 receptor agonist 1-deamino-8-d-arginine vasopressin increased renal cAMP and recovered the full cystic phenotype of PCK AVP(-/-) rats and aggravated the cystic disease of PCK AVP(+/+) rats but did not induce cystic changes in wild-type rats. These observations indicate that AVP is a powerful modulator of cystogenesis and provide further support for clinical trials of V2 receptor antagonists in PKD.
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Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Self-citationWard, C. J., Hogan, M. C., Rossetti, S., Walker, D., Sneddon, T., Wang, X., Kubly, V., Cunningham, J. M., Bacallao, R., Ishibashi, M., et al. (2002) · Nature Genetics · doi:10.1038/ng833 · Cited by 765
Self-citationGattone, V. H., Wang, X., Harris, P. C., & Torres, V. E. (2003) · Nature Medicine · doi:10.1038/nm935 · Cited by 670
Self-citationComparison of phenotypes of polycystic kidney disease types 1 and 2
Hateboer, N., v Dijk, M. A., Bogdanova, N., Coto, E., Saggar-Malik, A. K., Millan, J. L. S., Torra, R., Breuning, M., & Ravine, D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03495-3 · Cited by 628
Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease
Gabow, P. A., Johnson, A. M., Kaehny, W. D., Kimberling, W. J., Lezotte, D. C., Duley, I. T., & Jones, R. H. (1992) · Kidney International · doi:10.1038/ki.1992.195 · Cited by 509
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Torres, V. E., Wang, X., Qian, Q., Somlo, S., Harris, P. C., & Gattone, V. H. (2004) · Nature Medicine · doi:10.1038/nm1004 · Cited by 482
Self-citationSingle base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats
Schmale, H., & Richter, D. (1984) · Nature · doi:10.1038/308705a0 · Cited by 401
Wang, X., Gattone, V., Harris, P. C., & Torres, V. E. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004121090 · Cited by 334
Self-citationMechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases
Torres, V. E., & Harris, P. C. (2006) · Nature Clinical Practice Nephrology · doi:10.1038/ncpneph0070 · Cited by 296
Self-citationHarris, P. C., Bae, K. T., Rossetti, S., Torres, V. E., Grantham, J. J., Chapman, A. B., Guay-Woodford, L. M., King, B. F., Wetzel, L. H., Baumgarten, D. A., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080835 · Cited by 271
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Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
Torres, V. E., Chapman, A. B., Devuyst, O., Gansevoort, R. T., Grantham, J. J., Higashihara, E., Perrone, R. D., Krasa, H. B., Ouyang, J., & Czerwiec, F. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205511 · Cited by 1,614
Self-citationAutosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Self-citationInsufficient Sleep in Adolescents and Young Adults: An Update on Causes and Consequences
Owens, J., ADOLESCENT SLEEP WORKING GROUP, COMMITTEE ON ADOLESCENCE, Au, R., Carskadon, M., Millman, R., Wolfson, A., Braverman, P. K., Adelman, W. P., Breuner, C. C., et al. (2014) · Pediatrics · doi:10.1542/peds.2014-1696 · Cited by 1,413
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
Torres, V. E., Chapman, A. B., Devuyst, O., Gansevoort, R. T., Perrone, R. D., Koch, G., Ouyang, J., McQuade, R. D., Blais, J. D., Czerwiec, F. S., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1710030 · Cited by 639
Self-citationAutosomal dominant polycystic kidney disease
Cornec-Le Gall, E., Alam, A., & Perrone, R. D. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32782-x · Cited by 624
Metadata
- Authors
- Wang, X., Wu, Y., Ward, C. J., Harris, P. C., & Torres, V. E.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2008-01
- Volume
- 19
- Issue
- 1
- Pages
- 102-108
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2130729770
- Cited by
- 286
- References
- 30
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, X., Wu, Y., Ward, C. J., Harris, P. C., & Torres, V. E. (2008). Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2007060688
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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