The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain
Open accessAbstract
Although neurologic sequelae of acute kidney injury (AKI) are well described, the pathogenesis of acute uremic encephalopathy is poorly understood. This study examined the short-term effect of ischemic AKI on inflammatory and functional changes of the brain in mice by inducing bilateral renal ischemia for 60 min and studying the brains 24 h later. Compared with sham mice, mice with AKI had increased neuronal pyknosis and microgliosis in the brain. AKI also led to increased levels of the proinflammatory chemokines keratinocyte-derived chemoattractant and G-CSF in the cerebral cortex and hippocampus and increased expression of glial fibrillary acidic protein in astrocytes in the cortex and corpus callosum. In addition, extravasation of Evans blue dye into the brain suggested that the blood-brain barrier was disrupted in mice with AKI. Because liver failure also leads to encephalopathy, ischemic liver injury was induced in mice with normal renal function; neuronal pyknosis and glial fibrillary acidic protein expression were not increased, suggesting differential effects on the brain depending on the organ injured. For evaluation of the effects of AKI on brain function, locomotor activity was studied using an open field test. Mice subjected to renal ischemia or bilateral nephrectomy had moderate to severe declines in locomotor activity compared with sham-operated mice. These data demonstrate that severe ischemic AKI induces inflammation and functional changes in the brain. Targeting these pathways could reduce morbidity and mortality in critically ill patients with severe AKI.
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Cites
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Cited by
Mechanisms and treatment of organ failure in sepsis
Lelubre, C., & Vincent, J.-L. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0005-7 · Cited by 852
Crosstalk between the nervous system and the kidney
Tanaka, S., & Okusa, M. D. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.032 · Cited by 160
“Ultrasound application with a clinical machine 24 h before bilateral renal IRI ameliorated kidney injury in mice.”
BackgroundInfluentialRapamycin-inspired macrocycles with new target specificity
Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-018-0187-4 · Cited by 120
Self-citationBrain-kidney cross-talk: Definition and emerging evidence
Afsar, B., Sag, A. A., Yalcin, C. E., Kaya, E., Siriopol, D., Goldsmith, D., Covic, A., & Kanbay, M. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.032 · Cited by 44
Acute Kidney Injury and Adverse Outcomes of Critical Illness: Correlation or Causation?
Girling, B. J., Channon, S. W., Haines, R. W., & Prowle, J. R. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfz158 · Cited by 40
Metadata
- Authors
- Liu, M., Liang, Y., Chigurupati, S., Lathia, J. D., Pletnikov, M., Sun, Z., Crow, M., Ross, C. A., Mattson, M. P., & Rabb, H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2008-07
- Volume
- 19
- Issue
- 7
- Pages
- 1360-1370
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2098722533
- Cited by
- 401
- References
- 33
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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