The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
HIF in Kidney Disease and Development
Abstract
Tissue hypoxia is a pathologic feature of many human diseases including cancer, myocardial infarction, stroke, and kidney disease. An evolutionarily conserved oxygen-sensing mechanism enables cells to adapt and maintain homeostasis under hypoxic conditions by transcriptional activation of a host of genes that mediate metabolic adaptation, angiogenesis, energy conservation, erythropoiesis, and cell survival. The hypoxia-inducible factors (HIFs) comprise a family of oxygen-sensitive basic helix-loop-helix proteins that control the cellular transcriptional response to hypoxia. Inappropriate activation of the HIF system is linked to the development and/or progression of many human malignancies including clear cell renal cancer. HIFs are now postulated to play contrasting protective and pathogenic roles in acute and chronic kidney diseases, respectively. In this review, we discuss the mechanisms of oxygen sensing in renal cells and highlight the role of hypoxia and HIF activation under physiologic conditions and in renal development as well as in acute and chronic kidney diseases.
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
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Oxygen sensing by HIF hydroxylases
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Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
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Hypoxia requires Notch signaling to maintain the undifferentiated cell state
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Cited by
Cellular and molecular mechanisms of renal fibrosis
Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,446
Mechanisms of Tubulointerstitial Fibrosis
Zeisberg, M., & Neilson, E. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080793 · Cited by 868
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair
Nieuwenhuijs-Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J. S. F., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010253 · Cited by 328
The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease
Mimura, I., & Nangaku, M. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.124 · Cited by 302
Kim, S. G., Ahn, S.-Y., Lee, E. S., Kim, S., Na, K. Y., Chae, D.-W., & Chin, H. J. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.s2.s146 · Cited by 8
Metadata
- Authors
- Gunaratnam, L., & Bonventre, J. V.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-09
- Volume
- 20
- Issue
- 9
- Pages
- 1877-1887
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2107507822
- Cited by
- 173
- References
- 34
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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