The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury
Open accessAbstract
Both innate and adaptive mechanisms participate in the pathogenesis of kidney ischemia-reperfusion injury (IRI), but the role of regulatory immune mechanisms is unknown. We hypothesized that the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) protect against renal IRI. Partial depletion of Tregs with an anti-CD25 mAb potentiated kidney damage induced by IRI. Reducing the number of Tregs resulted in more neutrophils, macrophages, and innate cytokine transcription in the kidney after IRI but did not affect CD4(+) T cells or B cells. We performed adoptive transfer of lymph node cells from wild-type mice or FoxP3-deficient Scurfy mice into T cell- and B cell-deficient RAG-1 knockout mice to generate mice with and without FoxP3(+) Tregs, respectively. FoxP3(+) Treg-deficient mice accumulated a greater number of inflammatory leukocytes after renal IRI than mice containing Tregs. To confirm that a lack of Tregs potentiated renal injury, we co-transferred isolated Tregs and Scurfy lymph node cells; Treg repletion significantly attenuated IRI-induced renal injury and leukocyte accumulation. Furthermore, although adoptive transfer of wild-type Tregs into RAG-1 knockout mice was sufficient to prevent kidney IRI, transfer of IL-10-deficient Tregs was not. Taken together, these results demonstrate that Tregs modulate injury after kidney IRI through IL-10-mediated suppression of the innate immune system.
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Interleukin-10 and the Interleukin-10 Receptor
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A function for interleukin 2 in Foxp3-expressing regulatory T cells
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
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CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
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Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.
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Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function
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Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation
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Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Metadata
- Authors
- Kinsey, G. R., Sharma, R., Huang, L., Li, L., Vergis, A. L., Ye, H., Ju, S.-T., & Okusa, M. D.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-08
- Volume
- 20
- Issue
- 8
- Pages
- 1744-1753
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2150692938
- Cited by
- 351
- References
- 44
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Kinsey, G. R., Sharma, R., Huang, L., Li, L., Vergis, A. L., Ye, H., Ju, S.-T., & Okusa, M. D. (2009). Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2008111160
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