The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Macrophages in Renal Injury and Repair
Abstract
Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently available to prevent it or to promote kidney repair after injury. Animal models demonstrate that the macrophage is a major contributor to the inflammatory response to AKI. Emerging data from human biopsies also corroborate the presence of macrophages in AKI and their persistence in progressive chronic kidney disease. Macrophages are phagocytic innate immune cells that are important mediators of tissue homeostasis and host defense. In response to tissue injury, macrophages become activated based on specific signals from the damaged microenvironment. The activation and functional state of the macrophage depends on the stage of tissue injury and repair, reflecting a dynamic and diverse spectrum of macrophage phenotypes. In this review, we highlight our current understanding of the mechanisms by which macrophages contribute to injury and repair after AKI.
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Nonclassical Monocytes in Health and Disease
Narasimhan, P. B., Marcovecchio, P., Hamers, A. A. J., & Hedrick, C. C. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053119 · Cited by 484
Hu, Q., Lyon, C. J., Fletcher, J. K., Tang, W., Wan, M., & Hu, T. Y. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.014 · Cited by 309
Immune cells and inflammation in AKI to CKD progression
Sato, Y., & Yanagita, M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00195.2018 · Cited by 273
Control of innate immune response by biomaterial surface topography, energy, and stiffness
Abaricia, J. O., Farzad, N., Heath, T. J., Simmons, J., Morandini, L., & Olivares-Navarrete, R. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.021 · Cited by 199
Walton, R. G., Kosmac, K., Mula, J., Fry, C. S., Peck, B. D., Groshong, J. S., Finlin, B. S., Zhu, B., Kern, P. A., & Peterson, C. A. (2019) · Scientific Reports · doi:10.1038/s41598-018-37187-1 · Cited by 97
Metadata
- Authors
- Huen, S. C., & Cantley, L. G.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2017-02-10
- Volume
- 79
- Issue
- 1
- Pages
- 449-469
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2343540188
- Cited by
- 377
- References
- 133
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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