The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
IL-18 and Urinary NGAL Predict Dialysis and Graft Recovery after Kidney Transplantation
Open accessAbstract
Current methods for predicting graft recovery after kidney transplantation are not reliable. We performed a prospective, multicenter, observational cohort study of deceased-donor kidney transplant patients to evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL), IL-18, and kidney injury molecule-1 (KIM-1) as biomarkers for predicting dialysis within 1 wk of transplant and subsequent graft recovery. We collected serial urine samples for 3 d after transplant and analyzed levels of these putative biomarkers. We classified graft recovery as delayed graft function (DGF), slow graft function (SGF), or immediate graft function (IGF). Of the 91 patients in the cohort, 34 had DGF, 33 had SGF, and 24 had IGF. Median NGAL and IL-18 levels, but not KIM-1 levels, were statistically different among these three groups at all time points. ROC curve analysis suggested that the abilities of NGAL or IL-18 to predict dialysis within 1 wk were moderately accurate when measured on the first postoperative day, whereas the fall in serum creatinine (Scr) was not predictive. In multivariate analysis, elevated levels of NGAL or IL-18 predicted the need for dialysis after adjusting for recipient and donor age, cold ischemia time, urine output, and Scr. NGAL and IL-18 quantiles also predicted graft recovery up to 3 mo later. In summary, urinary NGAL and IL-18 are early, noninvasive, accurate predictors of both the need for dialysis within the first week of kidney transplantation and 3-mo recovery of graft function.
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Self-citationKidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
Han, W. K., Bailly, V., Abichandani, R., Thadhani, R., & Bonventre, J. V. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00433.x · Cited by 1,929
Self-citationMishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., & Devarajan, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088027.54400.c6 · Cited by 1,749
Self-citationGreenland, P. (2008) · Statistics in Medicine · doi:10.1002/sim.2976 · Cited by 1,300
Ichimura, T., Bonventre, J. V., Bailly, V., Wei, H., Hession, C. A., Cate, R. L., & Sanicola, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4135 · Cited by 1,265
High Survival Rates of Kidney Transplants from Spousal and Living Unrelated Donors
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Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
Moers, C., Smits, J. M., Maathuis, M.-H. J., Treckmann, J., van Gelder, F., Napieralski, B. P., van Kasterop-Kutz, M., van der Heide, J. J. H., Squifflet, J.-P., van Heurn, E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0802289 · Cited by 1,020
Delayed graft function in kidney transplantation
Perico, N., Cattaneo, D., Sayegh, M. H., & Remuzzi, G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17406-0 · Cited by 972
Cited by
Delayed Graft Function in the Kidney Transplant
Siedlecki, A., Irish, W., & Brennan, D. C. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03754.x · Cited by 817
Biomarkers of Acute Kidney Injury
Vaidya, V. S., Ferguson, M. A., & Bonventre, J. V. (2008) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094615 · Cited by 729
The Outcome of Neutrophil Gelatinase-Associated Lipocalin-Positive Subclinical Acute Kidney Injury
Haase, M., Devarajan, P., Haase-Fielitz, A., Bellomo, R., Cruz, D. N., Wagener, G., Krawczeski, C. D., Koyner, J. L., Murray, P., Zappitelli, M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.051 · Cited by 684
Self-citationDEVARAJAN, P. (2010) · Nephrology · doi:10.1111/j.1440-1797.2010.01317.x · Cited by 356
Self-citationNeutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
Devarajan, P. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.12 · Cited by 332
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Metadata
- Authors
- Hall, I. E., Yarlagadda, S. G., Coca, S. G., Wang, Z., Doshi, M., Devarajan, P., Han, W. K., Marcus, R. J., & Parikh, C. R.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2010-01
- Volume
- 21
- Issue
- 1
- Pages
- 189-197
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2170433159
- Cited by
- 340
- References
- 41
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Hall, I. E., Yarlagadda, S. G., Coca, S. G., Wang, Z., Doshi, M., Devarajan, P., Han, W. K., Marcus, R. J., & Parikh, C. R. (2010). IL-18 and Urinary NGAL Predict Dialysis and Graft Recovery after Kidney Transplantation. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2009030264
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