The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK
Open accessAbstract
Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.
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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
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Beyond insulin resistance in NASH: TNF-α or adiponectin?
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Plasma fetuin-A levels and the risk of type 2 diabetes
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Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
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Self-citationSite and mechanism of leptin action in a rodent form of congenital lipodystrophy
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Serum Adiponectin and Coronary Heart Disease Risk in Older Black and White Americans
Kanaya, A. M., Wassel Fyr, C., Vittinghoff, E., Havel, P. J., Cesari, M., Nicklas, B., Harris, T., Newman, A. B., Satterfield, S., Cummings, S. R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0107 · Cited by 71
Cited by
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747
Stern, J. H., Rutkowski, J. M., & Scherer, P. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.011 · Cited by 1,031
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922
Glomerular hyperfiltration: definitions, mechanisms and clinical implications
Helal, I., Fick-Brosnahan, G. M., Reed-Gitomer, B., & Schrier, R. W. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.19 · Cited by 673
NAFLD as a driver of chronic kidney disease
Byrne, C. D., & Targher, G. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.013 · Cited by 449
Metadata
- Authors
- Ix, J. H., & Sharma, K.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2010-03
- Volume
- 21
- Issue
- 3
- Pages
- 406-412
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2165056208
- Cited by
- 348
- References
- 10
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK. https://app.cochat.ai/papers/10.1681/asn.2009080820
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- Ix, J. H., & Sharma, K. (2010). Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2009080820
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
