NAFLD as a driver of chronic kidney disease
Abstract
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25-30% (NAFLD), and up to 10-15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD.
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There is uncertainty as to whether there is a direct causal link between MASLD and CKD as both diseases share common risk factors.
“Still, there is uncertainty as to whether there is a direct causal link between MASLD and CKD as both diseases share common risk factors. 227”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [227]
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- Authors
- Byrne, C. D., & Targher, G.
- Affiliations
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Verona (IT)
- Corresponding author
- Byrne, Christopher D.
- Targher, Giovanni
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 72
- Issue
- 4
- Pages
- 785-801
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W3006576880
- Cited by
- 449
- References
- 144
- Citations by year
- 2026: 45 · 2025: 72 · 2024: 76 · 2023: 85 · 2022: 79 · 2021: 57 · 2020: 34 · 2012: 1
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- NIHR Bristol Biomedical Research Centre (IS-BRC-20004)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, chronic kidney disease, CKD risk factors, metabolic syndrome, dysbiosis, platelet activation, aging, type 2 diabetes, obesity, hypertension, unhealthy diet, pathophysiological mechanisms
- MeSH terms
- Adolescent, Adult, Aging, Child, Diabetes Mellitus, Type 2, Diet, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, Platelet Activation, Comorbidity, Prevalence, Metabolic Syndrome, Renal Insufficiency, Chronic, Young Adult, Dysbiosis, Non-alcoholic Fatty Liver Disease
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