The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The Inflammasomes in Kidney Disease
Abstract
Renal inflammation is a universal response to infectious and noninfectious triggers. Sensors of the innate immune system, such as Toll-like receptors or RIG-like receptors, provide danger recognition platforms on renal cells that integrate and translate the diverse triggers of renal inflammation by inducing cell activation and the secretion of proinflammatory cytokines and chemokines. As a new entry, the inflammasome-forming NLR genes integrate various danger signals into caspase-1-activating platforms that regulate the processing and secretion of pro-IL-1β and pro-IL-18 into the mature and active cytokines. Accumulating data now document a role for the NLRP3 inflammasome and IL-1β/IL-18 in many diseases, including atherosclerosis, diabetes, amyloidosis, malaria, crystal-related diseases, and other autoinflammatory disorders, identifying this innate immune pathway as an attractive therapeutic target. Here we review the current knowledge regarding inflammasome signaling and outline existing evidence on the expression and functional role of the inflammasome-caspase-1-IL-1β/IL-18 axis in kidney disease. We further provide a perspective on the potential roles of the inflammasomes in the pathogenesis of acute and chronic kidney diseases.
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Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849
Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury
Zhao, W.-Y., Zhang, L., Sui, M.-X., Zhu, Y.-H., & Zeng, L. (2016) · Scientific Reports · doi:10.1038/srep33201 · Cited by 114
Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation
Li, Q., Fu, W., Yao, J., Ji, Z., Wang, Y., Zhou, Z., Yan, J., & Li, W. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-9823-9 · Cited by 39
Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
Frohlich, J., & Vinciguerra, M. (2020) · GeroScience · doi:10.1007/s11357-020-00279-w · Cited by 28
He, J., Lu, Y., Xia, H., Liang, Y., Wang, X., Bao, W., Yun, S., Ye, Y., Zheng, C., Liu, Z., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124469 · Cited by 20
Metadata
- Authors
- Anders, H.-J., & Muruve, D. A.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2011-06
- Volume
- 22
- Issue
- 6
- Pages
- 1007-1018
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2016741118
- Cited by
- 351
- References
- 118
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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