The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Immune Mechanisms in Arterial Hypertension
Open accessAbstract
Traditionally, arterial hypertension and subsequent end-organ damage have been attributed to hemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign organisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune system overreacts to internal injury, such as prehypertension. Renal inflammation results in injury and impaired urinary sodium excretion, and vascular inflammation leads to endothelial dysfunction, increased vascular resistance, and arterial remodeling and stiffening. Notably, modulation of the immune response can reduce the severity of BP elevation and hypertensive end-organ damage in several animal models. Indeed, recent studies have improved our understanding of how the immune response affects the pathogenesis of arterial hypertension, but the remarkable advances in basic immunology made during the last few years still await translation to the field of hypertension. This review briefly summarizes recent advances in immunity and hypertension as well as hypertensive end-organ damage.
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Cites
Innate or adaptive immunity? The example of natural killer cells
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Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
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Self-citationSodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
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Fate mapping of IL-17-producing T cells in inflammatory responses
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Late Developmental Plasticity in the T Helper 17 Lineage
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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
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Evidence for a link between gut microbiota and hypertension in the Dahl rat
Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., Haribabu, B., Vijay-Kumar, M., Pennathur, S., & Joe, B. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2014 · Cited by 400
Involvement of Bone Marrow Cells and Neuroinflammation in Hypertension
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Deciphering the tête-à-tête between the microbiota and the immune system
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Cited by
Salt-responsive gut commensal modulates TH17 axis and disease
Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., et al. (2017) · Nature · doi:10.1038/nature24628 · Cited by 1,310
Olsen, M. H., Angell, S. Y., Asma, S., Boutouyrie, P., Burger, D., Chirinos, J. A., Damasceno, A., Delles, C., Gimenez-Roqueplo, A.-P., Hering, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31134-5 · Cited by 939
Endothelial Dysfunction and Hypertension
Konukoglu, D., & Uzun, H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_90 · Cited by 594
When worlds collide: Th17 and Treg cells in cancer and autoimmunity
Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535
Instanes, J. T., Halmøy, A., Engeland, A., Haavik, J., Furu, K., & Klungsøyr, K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.024 · Cited by 192
Metadata
- Authors
- Wenzel, U., Turner, J. E., Krebs, C., Kurts, C., Harrison, D. G., & Ehmke, H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2016-03
- Volume
- 27
- Issue
- 3
- Pages
- 677-686
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W1925591757
- Cited by
- 205
- References
- 9
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Wenzel, U., Turner, J. E., Krebs, C., Kurts, C., Harrison, D. G., & Ehmke, H. (2016). Immune Mechanisms in Arterial Hypertension. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2015050562
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