Evidence for a link between gut microbiota and hypertension in the Dahl rat
Open accessAbstract
The gut microbiota plays a critical role in maintaining physiological homeostasis. This study was designed to evaluate whether gut microbial composition affects hypertension. 16S rRNA genes obtained from cecal samples of Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats were sequenced. Bacteria of the phylum Bacteroidetes were higher in the S rats compared with the R rats. Furthermore, the family S24-7 of the phylum Bacteroidetes and the family Veillonellaceae of the phylum Firmicutes were higher in the S rats compared with the R rats. Analyses of the various phylogenetic groups of cecal microbiota revealed significant differences between S and R rats. Both strains were maintained on a high-salt diet, administered antibiotics for ablation of microbiota, transplanted with S or R rat cecal contents, and monitored for blood pressure (BP). Systolic BP of the R rats remained unaltered irrespective of S or R rat cecal transplantation. Surprisingly, compared with the S rats given S rat cecal content, systolic BP of the S rats given a single bolus of cecal content from R rats was consistently and significantly elevated during the rest of their life, and they had a shorter lifespan. A lower level of fecal bacteria of the family Veillonellaceae and increased plasma acetate and heptanoate were features associated with the increased BP observed in the S rats given R rat microbiota compared with the S rats given S rat microbiota. These data demonstrate a link between microbial content and BP regulation and, because the S and R rats differ in their genomic composition, provide the necessary basis to further examine the relationship between the host genome and microbiome in the context of BP regulation in the Dahl rats.
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A salt-sensitive rat model with cecal microbial transplant demonstrated altered blood pressure and longevity in the recipient.
“A salt-sensitive rat model with cecal microbial transplant demonstrated altered blood pressure and longevity in the recipient84.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [84]
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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Self-citationPluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993 · see citing works
Theriot, C. M., Koenigsknecht, M. J., Carlson, P. E., Hatton, G. E., Nelson, A. M., Li, B., Huffnagle, G. B., Z. Li, J., & Young, V. B. (2014) · Nature Communications · doi:10.1038/ncomms4114 · Cited by 974 · see citing works
Gut microbiome-host interactions in health and disease
Kinross, J. K., Darzi, A. W., & Nicholson, J. K. (2011) · Genome Medicine · doi:10.1186/gm228 · Cited by 685 · see citing works
Dahl, L. K. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.2.231 · Cited by 650 · see citing works
Genetic Analysis of Inherited Hypertension in the Rat
Rapp, J. P. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.135 · Cited by 424 · see citing works
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397 · see citing works
Self-citationA novel SCFA receptor, the microbiota, and blood pressure regulation
Pluznick, J. (2014) · Gut Microbes · doi:10.4161/gmic.27492 · Cited by 374 · see citing works
Reshaping the gut microbiome with bacterial transplantation and antibiotic intakePreprint
Manichanh, C., Reeder, J., Gibert, P., Varela, E., Llopis, M., Antolı́n, M., Guigó, R., Knight, R. D., & Guarner, F. (2010) · Genome Research · doi:10.1101/gr.107987.110 · Cited by 332 · see citing works
The SCFA Receptor GPR43 and Energy Metabolism
Kimura, I., Inoue, D., Hirano, K., & Tsujimoto, G. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00085 · Cited by 297 · see citing works
The genetic dissection of essential hypertension
Cowley, A. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1967 · Cited by 289 · see citing works
Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets
Ulven, T. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00111 · Cited by 272 · see citing works
Dietary Salt Intake and Hypertension
Ha, S. K. (2014) · Electrolytes & Blood Pressure · doi:10.5049/ebp.2014.12.1.7 · Cited by 254 · see citing works
Possible role of salt intake in the development of essential hypertension*
Dahl, L. K. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyh317 · Cited by 230 · see citing works
Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome
Zupancic, M. L., Cantarel, B. L., Liu, Z., Drábek, E. F., Ryan, K. A., Cirimotich, S., Jones, C. E., Knight, R. D., Walters, W. A., Knights, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043052 · Cited by 213 · see citing works
The Large Intestine: Physiology, Pathophysiology, and Disease
Falchuk, Z. M. (1992) · JAMA · doi:10.1001/jama.1992.03480160114049 · Cited by 212 · see citing works
GPR43/FFA2: physiopathological relevance and therapeutic prospects
Bindels, L. B., Dewulf, E. M., & Delzenne, N. M. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.02.002 · Cited by 208 · see citing works
Microbiota-stimulated immune mechanisms to maintain gut homeostasis
Chung, H., & Kasper, D. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.008 · Cited by 207 · see citing works
Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!
Carvalho, F. A., Aitken, J. D., Vijay–Kumar, M., & Gewirtz, A. T. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153330 · Cited by 164 · see citing works
Self-citationFrom microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology
Natarajan, N., & Pluznick, J. L. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2014 · Cited by 163 · see citing works
Atanur, S. S., Diaz, A. I. G., Maratou, K., Sarkis, A. B., Rotival, M., Gamé, L., Tschannen, M., Kaisaki, P. J., Otto, G., Ma, M. C. J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.040 · Cited by 158 · see citing works
Self-citationVijay-Kumar, M., Chassaing, B., Kumar, M., Baker, M. T., & Singh, V. K. (2014) · Biomedical Journal · doi:10.4103/2319-4170.130922 · Cited by 155 · see citing works
Self-citationDirect sequencing of the human microbiome readily reveals community differences
Kuczynski, J., Costello, E. K., Nemergut, D. R., Zaneveld, J., Lauber, C. L., Knights, D., Koren, O., Fierer, N., Kelley, S. T., Ley, R. E., et al. (2010) · Genome biology · doi:10.1186/gb-2010-11-5-210 · Cited by 154 · see citing works
Feng, D., Yang, C., Geurts, A. M., Kurth, T., Liang, M., Lazar, J., Mattson, D. L., O'Connor, P. M., & Cowley, A. W. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.003 · Cited by 138 · see citing works
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Pluznick, J. L. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00252.2013 · Cited by 120 · see citing works
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Tilg, H. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dd8b64 · Cited by 102 · see citing works
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
Pravenec, M., Churchill, P. C., Churchill, M. C., Viklický, O., Kazdová, L., Aitman, T. J., Petretto, E. G., Hübner, N., Wallace, C. A., Zimdahl, H., et al. (2008) · Nature Genetics · doi:10.1038/ng.164 · Cited by 100 · see citing works
Gut microbiota and metabolic syndrome
D’Aversa, F., Tortora, A., Ianiro, G., Ponziani, F. R., Annicchiarico, B. E., & Gasbarrini, A. (2013) · Internal and Emergency Medicine · doi:10.1007/s11739-013-0916-z · Cited by 97 · see citing works
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significancePreprint
Atanur, S. S., Birol, İ., Guryev, V., Hirst, M., Hummel, O., Morrissey, C., Behmoaras, J. V., Fernández, X. M., Johnson, M. D., McLaren, W. M., et al. (2010) · Genome Research · doi:10.1101/gr.103499.109 · Cited by 94 · see citing works
Parekh, P. J., Arusi, E., Vinik, A. I., & Johnson, D. A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00047 · Cited by 94 · see citing works
EFFECTS OF CHRONIC EXCESS SALT INGESTION
Knudsen, K. D., Dahl, L. K., Thompson, K. H., Iwai, J., Heine, M., & Leitl, G. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.132.5.976 · Cited by 82 · see citing works
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension
Gopalakrishnan, K., Kumarasamy, S., Abdul-Majeed, S., Nestor‐Kalinoski, A. L., Morgan, E. E., Gohara, A. F., Nauli, S. M., Filipiak, W. E., Saunders, T. L., & Joe, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211290109 · Cited by 75 · see citing works
Self-citationNovel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension
Tian, Z., Liu, Y. U., Usa, K., Mladinov, D., Fang, Y., Ding, X., Greene, A. S., Cowley, A. W., & Liang, M. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.129528 · Cited by 74 · see citing works
Genetics of hypertension: From experimental animals to humans
Delles, C., McBride, M., Graham, D., Padmanabhan, S., & Dominiczak, A. F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.006 · Cited by 70 · see citing works
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Rogers, C. J., Prabhu, K. S., & Vijay–Kumar, M. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000049 · Cited by 67 · see citing works
Self-citationMutation of Plekha7 attenuates salt-sensitive hypertension in the rat
Endres, B. T., Priestley, J. R. C., Palygin, O., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410745111 · Cited by 60 · see citing works
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Noel, S., Martina-Lingua, M. N., Bandapalle, S., Pluznick, J. L., Hamad, A. R. A., Peterson, D. A., & Rabb, H. (2014) · Nephron Clinical Practice · doi:10.1159/000363209 · Cited by 59 · see citing works
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Gopalakrishnan, K., Kumarasamy, S., Mell, B., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04498 · Cited by 55 · see citing works
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Chassaing, B., Aitken, J. D., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00003-x · Cited by 49 · see citing works
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Doris, P. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00246.x · Cited by 49 · see citing works
Garrett, M. R., Joe, B., & Yerga‐Woolwine, S. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00150.2005 · Cited by 44 · see citing works
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Garrett, M. R., Meng, H., Rapp, J. P., & Joe, B. (2005) · Hypertension · doi:10.1161/01.hyp.0000154678.64340.7f · Cited by 38 · see citing works
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Joe, B. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04368 · Cited by 28 · see citing works
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Braun, M., Herring, S. M., Gokul, N., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000533 · Cited by 17 · see citing works
Molecular Mechanisms of Experimental Salt‐Sensitive Hypertension
Joe, B., & Shapiro, J. I. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.002121 · Cited by 16 · see citing works
Self-citationPillai, R., Waghulde, H., Nie, Y., et al. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00077.2013 · Cited by 16 · see citing works
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Escobar, E. N., Ibarra, C., Todisco, E., et al. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.259.5.g786 · Cited by 16 · see citing works
Rapp, J. P., & Joe, B. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00159.2013 · Cited by 12 · see citing works
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Self-citationSodium Chloride Transport of Normal and Dietary Enlarged Rat Cecum in vitro
Schreiner, J., Weber, M., & Loeschke, K. (1998) · Digestion · doi:10.1159/000007575 · Cited by 9 · see citing works
Rösel, E. F., & Engelhardt, W. V. (1996) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19960306 · Cited by 4 · see citing works
Salt, inflammation, pathophysiological mechanisms, and organ damage in hypertension
Zanchetti, A. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000106 · Cited by 2 · see citing works
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- Authors
- Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., Haribabu, B., Vijay-Kumar, M., Pennathur, S., & Joe, B.
- Affiliations
- University of Toledo (US)
- University of Louisville (US)
- University of Michigan (US)
- Department of Nutritional Sciences and Medicine, The Pennsylvania State University, University Park, Pennsylvania
- Corresponding author
- Joe, Bina
- ORCID
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2015-06
- Volume
- 47
- Issue
- 6
- Pages
- 187-197
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- PMC
- PMC4451389
- OpenAlex
- W2024324459
- Cited by
- 400
- References
- 58
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 30 · 2023: 33 · 2022: 50 · 2021: 60 · 2020: 63 · 2019: 32 · 2018: 29 · 2017: 31 · 2016: 17 · 2015: 7
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Genomics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL020176, HL-076709, R37HL020176, R01HL112641, R01HL076709, HL112641, HL020176)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-097153, DK-89503, U24DK097153, P30DK081943, DK-08194, P30DK020572, P30DK089503)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- gut microbiota, hypertension, Dahl salt-sensitive rats, Dahl salt-resistant rats, cecal microbiota, Bacteroidetes, Veillonellaceae, S24-7, high-salt diet, fecal microbiota transplantation, antibiotic-induced microbiota depletion, blood pressure regulation, acetate, heptanoate, lifespan, host-microbiome interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Blood Pressure, Cecum, Fatty Acids, Hypertension, Longevity, Sodium, Systole, Genetic Variation, Genome, Rats, Inbred Dahl, Kaplan-Meier Estimate, Metabolomics
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