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Red Meat Intake and Risk of ESRD
Open accessAbstract
Randomized controlled trials suggest that protein restriction may retard the progression of CKD toward ESRD. However, the effects of dietary protein intake level and the food sources of dietary protein on the risk of ESRD in the general population remain unclear. We investigated these effects in the Singapore Chinese Health Study, a prospective population-based cohort that recruited 63,257 Chinese adults aged 45-74 years from 1993 to 1998. We collected habitual diet information via a validated semiquantitative food frequency questionnaire and identified ESRD via record linkage with a nationwide registry. In all, 951 cases of ESRD occurred over a mean follow-up of 15.5 years. Regarding total protein intake, compared with the lowest quartile, the three higher quartiles combined had a hazard ratio for ESRD of 1.24 (95% confidence interval [95% CI], 1.05 to 1.46), but the dose-dependent association across the quartiles was not statistically significant (P trend =0.16). Red meat intake strongly associated with ESRD risk in a dose-dependent manner (hazard ratio for highest quartile versus lowest quartile,1.40 [95% CI, 1.15 to 1.71; P trend <0.001]). Intake of poultry, fish, eggs, or dairy products did not associate with risk of ESRD. In substitution analysis, replacing one serving of red meat with other food sources of protein associated with a maximum relative risk reduction of 62.4% (95% CI, 33.1 to 78.9; P<0.01). Our study shows that red meat intake may increase the risk of ESRD…
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“observational studies have reported that high consumption of red and processed meat is associated with increased risk of CKD progression and mortality”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [282]
In the citing paper
“fruit and vegetable intake were associated with decline in progression of kidney disease. 280 -282”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [282]
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KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease
de Boer, I. H., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.06.019 · Cited by 1,399
KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Rossing, P., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.008 · Cited by 1,373
The Effects of High-Protein Diets on Kidney Health and Longevity
Ko, G.-J., Rhee, C. M., Kalantar-Zadeh, K., & Joshi, S. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020010028 · Cited by 345
Haring, B., Selvin, E., Liang, M., Coresh, J., Grams, M. E., Petruski-Ivleva, N., Steffen, L. M., & Rebholz, C. M. (2017) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2016.11.004 · Cited by 254
Healthy Dietary Patterns and Risk of Mortality and ESRD in CKD: A Meta-Analysis of Cohort Studies
Kelly, J. T., Palmer, S. C., Wai, S. N., Ruospo, M., Carrero, J. J., Campbell, K. L., & Strippoli, G. F. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06190616 · Cited by 305
Metadata
- Authors
- Lew, Q.-L. J., Jafar, T. H., Koh, H. W. L., Jin, A., Chow, K. Y., Yuan, J.-M., & Koh, W.-P.
- Affiliations
- SingHealth Polyclinics (SG)
- Singapore General Hospital (SG)
- National University of Singapore (SG)
- Health Promotion Board (SG)
- University of Pittsburgh (US)
- Corresponding author
- Lew, Quan-Lan Jasmine
- Yuan, Jian-Min
- Venue
- Journal of the American Society of Nephrology
- Published
- 2016-07-14
- Volume
- 28
- Issue
- 1
- Pages
- 304-312
- ISSN
- 1046-6673 (ISSN-L)
- 1533-3450
- PMC
- PMC5198288
- OpenAlex
- W2464978253
- Cited by
- 222
- References
- 0
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 26 · 2023: 31 · 2022: 28 · 2021: 23 · 2020: 33 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 4
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National University of Singapore
- National Cancer Institute (R01CA144034, R01CA080205, UM1CA182876)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
- Keywords
- red meat consumption, end-stage renal disease, protein intake, protein restriction, chronic kidney disease progression, protein source substitution, poultry, fish, eggs, dairy products, dose-response relationship, Singapore Chinese Health Study
- MeSH terms
- Red Meat, Aged, Female, Humans, Kidney Failure, Chronic, Male, Middle Aged, Prospective Studies, Risk Factors
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