The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Glomerular Slit Diaphragm Is a Modified Adherens Junction
Abstract
Abstract.: The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed with P-cadherin as well as with α-, β-, and γ-catenin. In situ, P-cadherin was detected at the slit diaphragm in association with ZO-1 as shown by confocal microscopy and immunogold double labeling electron microscopy. P-cadherin expression in vivo and in vitro was confirmed by reverse transcription-PCR. These findings led to the concept that the slit diaphragm represents an adherens junction composed of P-cadherin, α-, β-, and γ-catenin, and ZO-1. In contrast to an adherens junction of a similar composition recently described in cultured fibroblasts, the slit diaphragm complex does not contain vinculin, which was found in nearby focal contacts. A P-cadherinbased adherens junction is well-suited to explain the zipper-like structure of the slit diaphragm. The present study should allow new avenues leading to the identification of additional slit diaphragm-associated proteins conferring specificity to this unique cell junction.
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Cites
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Structural basis of cell-cell adhesion by cadherins
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Self-citationNephrin is specifically located at the slit diaphragm of glomerular podocytes
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POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE
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Cited by
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Self-citationPutaala, H. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.1.1 · Cited by 533
Patrakka, J., Kestilä, M., Wartiovaara, J., Ruotsalainen, V., Tissari, P., Lenkkeri, U., Männikkö, M., Visapää, I., Holmberg, C., Rapola, J., et al. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00254.x · Cited by 310
The podocyte slit diaphragm--from a thin grey line to a complex signalling hub
Grahammer, F., Schell, C., & Huber, T. B. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.169 · Cited by 269
How Does the Kidney Filter Plasma?
Tryggvason, K., & Wartiovaara, J. (2005) · Physiology · doi:10.1152/physiol.00045.2004 · Cited by 126
Metadata
- Authors
- REISER, J., KRIZ, W., KRETZLER, M., & MUNDEL, P.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2000-01
- Volume
- 11
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2124565234
- Cited by
- 466
- References
- 25
- FWCI
- 21.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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