The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death
Abstract
A mouse model for congenital nephrotic syndrome (NPHS1) was generated by inactivating the nephrin gene (Nphs1) in embryonic stem cells by homologous recombination. The targeting construct contained the Escherichia coli lacZ gene as a reporter for the Nphs1 promoter. Mice homozygous for inactivated Nphs1 were born at an expected frequency of 25%. Although seemingly normal at birth, they immediately developed massive proteinuria and edema and died within 24 h. The kidneys of null mice exhibited enlarged Bowman's spaces, dilated tubuli, effacement of podocyte foot processes and absence of the slit diaphragm, essentially as found in human NPHS1 patients. In addition to expression in glomerular podocytes, the reporter gene was expressed in the brain and pancreas of (+/-) and (-/-) mice. In the brain, expression was localized to the ventricular zone of the fourth ventricle, the developing spinal cord, cerebellum, hippocampus and olfactory bulb. In the cerebellum, the expression was seen in radial glial cells. Neither anatomical nor morphological abnormalities were observed in the brains of null mice.
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Kestilä, M., Lenkkeri, U., Männikkö, M., Lamerdin, J., McCready, P., Putaala, H., Ruotsalainen, V., Morita, T., Nissinen, M., Herva, R., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80057-x · Cited by 1,866
Self-citationBoute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.-C., Niaudet, P., & Antignac, C. (2000) · Nature Genetics · doi:10.1038/74166 · Cited by 1,444
Rakic, P. (1971) · Journal of Comparative Neurology · doi:10.1002/cne.901410303 · Cited by 1,339
Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein
Shih, N.-Y., Li, J., Karpitskii, V., Nguyen, A., Dustin, M. L., Kanagawa, O., Miner, J. H., & Shaw, A. S. (1999) · Science · doi:10.1126/science.286.5438.312 · Cited by 861
CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION
Hatten, M. E. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.511 · Cited by 797
Nephrin is specifically located at the slit diaphragm of glomerular podocytes
Ruotsalainen, V., Ljungberg, P., Wartiovaara, J., Lenkkeri, U., Kestilä, M., Jalanko, H., Holmberg, C., & Tryggvason, K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7962 · Cited by 767
Mechanisms of Neural Patterning and Specification in the Development Cerebellum
Hatten, M. E., & Heintz, N. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002125 · Cited by 576
Gene targeting: a practical approach.
Joyner, A. L. (1993) · Cited by 575
The Glomerular Slit Diaphragm Is a Modified Adherens Junction
REISER, J., KRIZ, W., KRETZLER, M., & MUNDEL, P. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1111 · Cited by 466
Dahl, D. R., Rueger, D. C., Bignami, A., Weber, K., & Osborn, M. (1981) · PubMed · Cited by 441
Cited by
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Sugimoto, H., Hamano, Y., Charytan, D., Cosgrove, D., Kieran, M., Sudhakar, A., & Kalluri, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300012200 · Cited by 538
Doublier, S., Ruotsalainen, V., Salvidio, G., Lupia, E., Biancone, L., Conaldi, P. G., Reponen, P., Tryggvason, K., & Camussi, G. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64128-4 · Cited by 257
Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks
Boerries, M., Grahammer, F., Eiselein, S., Buck, M., Meyer, C., Goedel, M., Bechtel, W., Zschiedrich, S., Pfeifer, D., Laloë, D., et al. (2013) · Kidney International · doi:10.1038/ki.2012.487 · Cited by 141
How Does the Kidney Filter Plasma?
Tryggvason, K., & Wartiovaara, J. (2005) · Physiology · doi:10.1152/physiol.00045.2004 · Cited by 126
Metadata
- Authors
- Putaala, H.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2153534186
- Cited by
- 533
- References
- 22
- FWCI
- 26.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. https://app.cochat.ai/papers/10.1093/hmg/10.1.1
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- Putaala, H. (2001). The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Human Molecular Genetics. https://doi.org/10.1093/hmg/10.1.1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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