The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The Kidney and Homocysteine Metabolism
Abstract
Homocysteine (Hcy) is an intermediate of methionine metabolism that, at elevated levels, is an independent risk factor for vascular disease and atherothrombosis. Patients with renal disease, who exhibit unusually high rates of cardiovascular morbidity and death, tend to be hyperhomocysteinemic, particularly as renal function declines. This observation and the inverse relationship between Hcy levels and GFR implicate the kidney as an important participant in Hcy handling. The normal kidney plays a major role in plasma amino acid clearance and metabolism. The existence in the kidney of specific Hcy uptake mechanisms and Hcy-metabolizing enzymes suggests that this role extends to Hcy. Dietary protein intake may affect renal Hcy handling and should be considered when measuring Hcy plasma flux and renal clearance. The underlying cause of hyperhomocysteinemia in renal disease is not entirely understood but seems to involve reduced clearance of plasma Hcy. This reduction may be attributable to defective renal clearance and/or extrarenal clearance and metabolism, the latter possibly resulting from retained uremic inhibitory substances. Although the currently available evidence is not conclusive, it seems more likely that a reduction in renal Hcy clearance and metabolism is the cause of the hyperhomocysteinemic state. Efforts to resolve this important issue will advance the search for effective Hcy-lowering therapies in patients with renal disease.
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Cites
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Methionine metabolism in mammals
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Self-citationLowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials
Collaboration, H. L. T. (1998) · BMJ · doi:10.1136/bmj.316.7135.894 · Cited by 1,084
Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence
Eikelboom, J. W., Lonn, E., Genest, J., Hankey, G., & Yusuf, S. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-5-199909070-00008 · Cited by 908
Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease
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Cardiovascular disease and chronic renal disease: A new paradigm
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Self-citationLabile methyl balances for normal humans on various dietary regimens
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Cited by
The Homocysteine Hypothesis of Depression
Folstein, M., Liu, T., Peter, I., Buel, J., Arsenault, L., Scott, T., & Qiu, W. W. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.861 · Cited by 262
Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide
Pushpakumar, S., Kundu, S., & Sen, U. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706142335 · Cited by 256
Taskinen, M.-R., Sullivan, D. R., Ehnholm, C., Whiting, M., Zannino, D., Simes, R. J., Keech, A. C., & Barter, P. J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.178228 · Cited by 63
Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., & Smith, S. M. (2017) · The FASEB Journal · doi:10.1096/fj.201700294 · Cited by 59
Deminice, R., Rosa, F. T., Franco, G. S., da Cunha, S. F. C., de Freitas, E. C., & Jordao, A. A. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0636-1 · Cited by 20
Metadata
- Authors
- FRIEDMAN, A. N., BOSTOM, A. G., SELHUB, J., LEVEY, A. S., & ROSENBERG, I. H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2001-10
- Volume
- 12
- Issue
- 10
- Pages
- 2181-2189
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2115276193
- Cited by
- 288
- References
- 44
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- FRIEDMAN, A. N., BOSTOM, A. G., SELHUB, J., LEVEY, A. S., & ROSENBERG, I. H. (2001). The Kidney and Homocysteine Metabolism. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.v12102181
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
