The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
The Homocysteine Hypothesis of Depression
Abstract
High levels of homocysteine are associated with cerebrovascular disease, monoamine neurotransmitters, and depression of mood. A plausible hypothesis for these associations is that high homocysteine levels cause cerebral vascular disease and neurotransmitter deficiency, which cause depression of mood. The homocysteine depression hypothesis, if true, would mandate inclusions of imaging studies for cerebrovascular disease and measures of homocysteine, folate, and B12 and B6 vitamins in the clinical evaluation of older depressed patients. Longitudinal studies and clinical trials should be designed to challenge the hypothesis.
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Cites
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Cited by
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
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Metadata
- Authors
- Folstein, M., Liu, T., Peter, I., Buel, J., Arsenault, L., Scott, T., & Qiu, W. W.
- Venue
- American Journal of Psychiatry
- Published
- 2007-06
- Volume
- 164
- Issue
- 6
- Pages
- 861-867
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2090363141
- Cited by
- 262
- References
- 102
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Folstein, M., Liu, T., Peter, I., Buel, J., Arsenault, L., Scott, T., & Qiu, W. W. (2007). The Homocysteine Hypothesis of Depression. American Journal of Psychiatry. https://doi.org/10.1176/ajp.2007.164.6.861
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
