. Prediction, progression and outcomes of chronic kidney disease in older adults.
Abstract
Chronic kidney disease is a large and growing problem among aging populations. Although progression of chronic kidney disease to end-stage renal disease (ESRD) is a costly and important clinical event with substantial morbidity, it appears less frequently in aging people compared with cardiovascular mortality. The measurement of kidney function and management of kidney disease in older individuals remain challenging, partly because the pathophysiologic mechanisms underlying age-related decline in kidney function, the interactions between age and other risk factors in renal progression, and the associations of chronic kidney disease with other comorbidities in older people are understudied and poorly understood. The Association of Specialty Professors, the American Society of Nephrology, the American Geriatrics Society, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases held a workshop, summarized in this article, to review what is known about chronic kidney disease, identify research gaps and resources available to address them, and identify priority areas for future research. Answers to emerging research questions will support the integration of geriatrics and nephrology and thus improve care for older patients at risk for chronic kidney disease.
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eGFR and albuminuria are independent predictors of cardiovascular risk in those with chronic kidney disease.
“For example, eGFR and albuminuria are independent predictors of cardiovascular risk in those with chronic kidney disease (54).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [54]
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- Authors
- Anderson, S., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kaysen, G. A., Kusek, J. W., Nayfield, S. G., Schmader, K., Tian, Y., Ashworth, J. R., Clayton, C. P., Parker, R. P., Tarver, E. D., Woolard, N. F., & High, K. P.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- High, Kevin P.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-06
- Volume
- 20
- Issue
- 6
- Pages
- 1199-1209
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2168713667
- Cited by
- 218
- References
- 146
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 16 · 2019: 14 · 2018: 15 · 2017: 19 · 2016: 19 · 2015: 16 · 2014: 6 · 2013: 15 · 2012: 10
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P30AG028716)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chronic kidney disease, older adults, aging, end-stage renal disease, renal function decline, comorbidities, kidney disease progression, geriatric nephrology, research priorities
- MeSH terms
- Aged, Aging, Cardiovascular Diseases, Humans, Comorbidity, Disease Progression, Biomedical Research, Renal Insufficiency, Chronic, Acute Kidney Injury
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