The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial
Abstract
The aim of this study was to determine the effects of caffeine and chlorogenic acid supplementation on gut microbiota, and metabolic disturbances in patients with NAFLD and diabetes. In this randomized, placebo-controlled, clinical trial, 26 patients with diabetes and NAFLD were randomly assigned to four groups to receive either 200 mg caffeine plus 200 mg chlorogenic acid (CFCA), or 200 mg caffeine plus 200 mg placebo (starch) (CFPL), or 200 mg chlorogenic acid plus 200 mg placebo (CAPL), or 200 mg placebo plus 200 mg placebo (PLPL) for 12 weeks. After 3 months of supplementation, patients in the intervention groups showed a significant decrease in body weight (CFCA group =-3.69 kg; CFPL group=-0.7kg; CAPL group=-0.43kg; PLPL group=0.26 kg) (p=0.004). Weight reduced significantly more in CFCA group compared to all other three groups (p=0.005 for PLPL; p=0.023 for CAPL; and p=0.031 for CFPL). Although the number of gut Bifidobacteria increased in CFCA group, there were no statistically significant differences within and between the groups in any of bacteria numbers. In conclusion, our study showed that 12 weeks consumption of 200 mg/day caffeine plus 200 mg/day chlorogenic acid is effective in reduction of weight in patients with NAFLD and diabetes which might be at least partially through the rise in gut Bifidobacteria. This pilot study shed a light on the pathway of future clinical trials assessing the effects of coffee consumption in these patients. This trial has been registered at clinicaltrial.gov with registration number of NCT02929901.
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“A recent intervention study reported that the ingestion of 200 mg caffeine along with 200 mg chlorogenic acids increased the population of Bifidobacteria, while neither caffeine nor chlorogenic acids provided separately achieved this effect [144].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [144]
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28548 · Cited by 364 · cited 1×
“…are limited to healthy volunteers without assessment of weight loss (Wedick et al., 2011), and with controversial results in assessment of other metabolic disturbances (Agudelo-Ochoa et al., 2016; Kempf et al., 2010; Lecoultre et al., 2014; Moisey et al., 2008; Papakonstantinou et al., 2016).”
BackgroundMoisey, L. L., Kacker, S., Bickerton, A. C., Robinson, L. E., & Graham, T. E. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1254 · Cited by 127
Papakonstantinou, E., Kechribari, I., Sotirakoglou, Κ., Tarantilis, P., Gourdomichali, T., Michas, G., Kravvariti, V., Voumvourakis, K., & Zampelas, A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0146-0 · Cited by 59 · cited 2×
“, 2011), and with controversial results in assessment of other metabolic disturbances (Agudelo-Ochoa et al., 2016; Kempf et al., 2010; Lecoultre et al., 2014; Moisey et al., 2008; Papakonstantinou et al., 2016).”
BackgroundResultCuervo, A., Hevia, A., López, P., Suárez, A., Diaz, C., Sánchez, B., Margolles, A., & González, S. (2016) · Food & Function · doi:10.1039/c5fo00853k · Cited by 32
Cited by
Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update
Nehlig, A. (2022) · Nutrients · doi:10.3390/nu14020399 · Cited by 158
Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis
Komolafe, O., Buzzetti, E., Linden, A., Best, L. M., Madden, A. M., Roberts, D., Chase, T. J., Fritche, D., Freeman, S. C., Cooper, N. J., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013157.pub2 · Cited by 21
Metadata
- Authors
- Mansour, A., Mohajeri-Tehrani, M. R., Karimi, S., Sanginabadi, M., Poustchi, H., Enayati, S., Asgarbeik, S., Nasrollahzadeh, J., & Hekmatdoost, A.
- Venue
- EXCLI Journal
- Published
- 2020-03-02
- Volume
- 19
- Pages
- 241-250
- ISSN
- 1611-2156
- Cited by
- 1
- References
- 5
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- Mansour, A., Mohajeri-Tehrani, M. R., Karimi, S., Sanginabadi, M., Poustchi, H., Enayati, S., Asgarbeik, S., Nasrollahzadeh, J., & Hekmatdoost, A. (2020). Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial. EXCLI Journal. https://doi.org/10.17179/excli2019-2021
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
