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Cited by 127Coffee research and impactsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men

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Moisey, Lesley L, Kacker, Sita, Bickerton, Andrea C, Robinson, Lindsay E, Graham, Terry E·2008·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/87.5.1254
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Abstract

Background The ingestion of caffeine (5 mg/kg body weight) and a 75-g oral glucose load has been shown to elicit an acute insulin-insensitive environment in healthy and obese individuals and in those with type 2 diabetes.Objective In this study we investigated whether a similar impairment in blood glucose management exists when coffee and foods typical of a Western diet were used in a similar protocol.Design Ten healthy men underwent 4 trials in a randomized order. They ingested caffeinated (5 mg/kg) coffee (CC) or the same volume of decaffeinated coffee (DC) followed 1 h later by either a high or low glycemic index (GI) cereal (providing 75 g of carbohydrate) mixed meal tolerance test.Results CC with the high GI meal resulted in 147%, 29%, and 40% greater areas under the curve for glucose (P < 0.001), insulin (NS), and C-peptide (P < 0.001), respectively, compared with the values for DC. Similarly, with the low GI treatment, CC elicited 216%, 44%, and 36% greater areas under the curve for glucose (P < 0.001), insulin (P < 0.01), and C-peptide (P < 0.01), respectively. Insulin sensitivity was significantly reduced (40%) with the high GI treatment after CC was ingested compared with DC; with the low GI treatment, CC ingestion resulted in a 29% decrease in insulin sensitivity, although this difference was not significant.Conclusion The ingestion of CC with either a high or low GI meal significantly impairs acute blood glucose management and insulin sensitivity compared with ingestion of DC. Future investigations are warranted to determine whether CC is a risk factor for insulin resistance.

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  • Higher iron intake, especially haem iron, and higher iron status are associated with increased risk of type 2 diabetes, atherosclerosis and coronary heart disease, although the literature is not fully consistent.

    “There is some epidemiological evidence that higher Fe intake, particularly that of haem Fe, and higher Fe status are associated with increased risk of type 2 diabetes, atherosclerosis and CHD (702 -714) , although not all of the literature is consistent.”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [711]

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Authors
Moisey, L. L., Kacker, S., Bickerton, A. C., Robinson, L. E., & Graham, T. E.
Affiliations
University of Guelph (CA)
Corresponding author
Graham, Terry E
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2008-05
Volume
87
Issue
5
Pages
1254-1261
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/87.5.1254
OpenAlex
W1905122931
Cited by
127
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 15 · 2012: 9
FWCI
7.49
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
caffeinated coffee, caffeine, blood glucose homeostasis, glycemic index, insulin sensitivity, insulin resistance, mixed meal tolerance test, C-peptide, decaffeinated coffee, Western diet
MeSH terms
Adolescent, Adult, Blood Glucose, C-Peptide, Caffeine, Edible Grain, Coffee, Dietary Carbohydrates, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Cross-Over Studies, Area Under Curve, Glycemic Index

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