Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Open accessAbstract
Background Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.Objective The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Design Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Results Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Conclusions Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.
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Cardiorespiratory fitness is inversely associated with fibrinogen and white blood cell count.
“Analyses with fibrinogen and white blood cell count showed similar results (249) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [249]
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“Further studies that account for the complex biomarker interrelations are needed to better understand Caffeinated coffee Total adiponectin n 2822 3640 4507 1826 Model 1 0 (ref) 1.0 (−1.2, 3.2) 4.6 (2.4, 6.8) 9.0 (6.2, 12.0) 1.9 (1.4, 2.5) 0.001 Model 2 0 (ref) 0.2 (−1.9, 2.3) 3.0 (1.0, 5.2) 8.8 (6.0, 11.7) 1.9 (1.3, 2…”
BackgroundResultInfluentialTakami, H., Nakamoto, M., Uemura, H., Katsuura, S., Yamaguchi, M., Hiyoshi, M., Sawachika, F., Juta, T., & Arisawa, K. (2012) · Journal of Epidemiology · doi:10.2188/jea.je20120053 · Cited by 102 · see citing works
Martínez‐López, S., Sarriá, B., Mateos, R., & Bravo, L. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1726-x · Cited by 101 · see citing works
Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications
Zhang, S., Xu, M., Zhang, W., Liu, C., & Chen, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116110 · Cited by 102 · see citing works
Paiva, C., Beserra, B. T. S., Reis, C., Dórea, J. G., Costa, T. D., & Amato, A. A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1386159 · Cited by 99 · see citing works
“Likewise, Kempf et al (2010) analyzed their data by categorizing participants into subgroups with low or high insulin resistance, according to the median HOMA-IR value, and found that the effect of coffee in suppressing the proinflammatory markers IL-18 and 8-isoprostane was significant only in the…”
BackgroundMethodResultInfluentialSurma, S., Sahebkar, A., & Banach, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106596 · Cited by 99 · see citing works
Rodríguez‐Artalejo, F., & López‐García, E. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04506 · Cited by 99 · see citing works
Mansour, A., Mohajeri-Tehrani, M. R., Samadi, M., Qorbani, M., Merat, S., Adibi, H., Poustchi, H., & Hekmatdoost, A. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00694-5 · Cited by 98 · see citing works
“The association between coffee consumption and serum lipids have been studied extensively, however, yielded inconsistent results [28].”
ResultInfluentialRole of coffee in modulation of diabetes risk
Natella, F., & Scaccini, C. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00470.x · Cited by 94 · see citing works
Coffee Consumption and Risk of Stroke in Women
Larsson, S. C., Virtamo, J., & Wolk, A. (2011) · Stroke · doi:10.1161/strokeaha.110.603787 · Cited by 93 · see citing works
Aleksandrova, K., Bamia, C., Drogan, D., Λάγιου, Π., Trichopoulou, A., Jenab, M., Fedirko, V., Romieu, I., Bueno-de-Mesquita, H. B., Pischon, T., et al. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116095 · Cited by 93 · see citing works
Association of Coffee Consumption With All-Cause and Cardiovascular Disease Mortality
Liu, J., Sui, X., Lavie, C. J., Hebert, J. R., Earnest, C. P., Zhang, J., & Blair, S. N. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.020 · Cited by 90 · see citing works
“Recent research has found that coffee is one of the major sources of antioxidants in the diet(29,30) and has potential beneficial effects on inflammation.(31,32) However, it is also well known that coffee has potential adverse effects because of caffeine’s potential to stimulate the release of epinephrine,(33) inhibit…”
BackgroundHow coffee affects metabolic syndrome and its components
Başpınar, B., Eskici, G., & Özçelik, A. Ö. (2017) · Food & Function · doi:10.1039/c7fo00388a · Cited by 90 · see citing works
Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome
Sarriá, B., Martínez‐López, S., Sierra-Cinos, J. L., García‐Diz, L., Mateos, R., & Bravo, L. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1316-8 · Cited by 91 · see citing works
Bułdak, R. J., Hejmo, T., Osowski, M., Bułdak, Ł., Kukla, M., Polaniak, R., & Birkner, E. (2018) · Molecules · doi:10.3390/molecules23123309 · Cited by 89 · see citing works
“Coffee has a variable impact on serum cholesterol level, as increased or unaffected concentrations have been reported [12,16,22,23].”
BackgroundCaffeine intake and the risk of kidney stones
Ferraro, P. M., Taylor, E. N., Gambaro, G., & Curhan, G. C. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089987 · Cited by 90 · see citing works
“Age-adjusted Ref 0 (27, 8) 22 (26, 2) 24 (211, 3) 26 (211, 21) ,0.”
Shi, X., Xue, W., Liang, S., Zhao, J., & Zhang, X. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0220-7 · Cited by 89 · see citing works
“However, the underlying mechanism remains unclear, and the results of bedside and bench-based research are controversial [19, 24, 25].”
BackgroundHyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?
Paganelli, F. F., Mottola, G., Fromonot, J., Marlinge, M., Deharo, P., Guieu, R., & Ruf, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041690 · Cited by 93 · see citing works
Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers
Loftfield, E., Shiels, M. S., Graubard, B. I., Katki, H. A., Chaturvedi, A. K., Trabert, B. L., Pinto, L. A., Kemp, T. J., Shebl, F. M., Mayne, S. T., et al. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0038-t · Cited by 84 · see citing works
“We also found null associations for coffee drinking and four markers [monocyte chemoattractant protein-1 (CCL2/MCP-1), IL1b, IL1ra, and insulin] consistent with the results from prior studies (17, 20, 21).”
ResultAlperet, D. J., Rebello, S. A., Khoo, E. Y.-H., Tay, Z., Seah, S. S. Y., Tai, B., Tai, E. S., Emady‐Azar, S., Chou, C. J., Darimont, C., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz306 · Cited by 81 · see citing works
Peluso, I., Raguzzini, A., & Serafini, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200721 · Cited by 81 · see citing works
“Studies are listed in [25–134].”
BackgroundImpact of coffee components on inflammatory markers: A review
Frost-Meyer, N. J., & Logomarsino, J. V. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.05.010 · Cited by 79 · see citing works
Ohnaka, K., Ikeda, M., Maki, T., Okada, T., Shimazoe, T., Adachi, M., Nomura, M., Takayanagi, R., & Kono, S. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/207426 · Cited by 79 · see citing works
“None of these studies showed a clear effect on either fasting [15, 16] or postload [17, 18]”
BackgroundRegazzoni, L., Saligari, F., Marinello, C., Rossoni, G., Aldini, G., Carini, M., & Orioli, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.11.027 · Cited by 79 · see citing works
Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter
Rebello, S. A., & van Dam, R. M. (2013) · Current Cardiology Reports · doi:10.1007/s11886-013-0403-1 · Cited by 78 · see citing works
“The limited clinical studies done thus far have been somewhat promising, with increases in total ex vivo antioxidant capacity [36], ex vivo hemocyte antioxidant enzyme activity [36–38], and reductions in urinary 8-isoprostane concentration [9, 39], in vitro/ex vivo oxidative DNA damage”
InfluentialRebello, S. A., Chen, C. H., Naidoo, N., Xu, W., Lee, J., Chia, K. S., Tai, E. S., & van Dam, R. M. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-61 · Cited by 78 · see citing works
“In an intervention study, serum adiponectin concentration increased when participants consumed eight cups of coffee per day as compared to when they did not consume coffee [17].”
BackgroundRamos-López, O., Martínez‐Urbistondo, D., Vargas-Núñez, J. A., & Martínez, J. A. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00490-0 · Cited by 79 · see citing works
Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality
Hu, Y., Ding, M., Yuan, C., Wu, K., Smith-Warner, S. A., Hu, F. B., Chan, A. T., Meyerhardt, J. A., Ogino, S., Fuchs, C. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.010 · Cited by 75 · see citing works
Gavrieli, A., Yannakoulia, M., Fragopoulou, E., Margaritopoulos, D., Chamberland, J. P., Kaisari, P., Kavouras, S. A., & Mantzoros, C. S. (2011) · Journal of Nutrition · doi:10.3945/jn.110.137323 · Cited by 75 · see citing works
Cao, C., Wang, L., Lin, X., Mamcarz, M. B., Zhang, C., Bai, G., Nong, J., Sussman, S., & Arendash, G. W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110110 · Cited by 75 · see citing works
Shechter, M., Shalmon, G., Scheinowitz, M., Koren-Morag, N., Feinberg, M. S., Harats, D., Sela, B. A., Sharabi, Y., & Chouraqui, P. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.12.035 · Cited by 74 · see citing works
Erk, T., Williamson, G., Renouf, M., Marmet, C., Steiling, H., Dionisi, F., Barron, D., Melcher, R., & Richling, E. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200222 · Cited by 74 · see citing works
Taram, F., Winter, A. N., & Linseman, D. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.028 · Cited by 73 · see citing works
Martínez-López, S., Sarriá, B., Baeza, G., Mateos, R., & Bravo, L. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.043 · Cited by 72 · see citing works
Jacobs, S., Kröger, J., Floegel, A., Boeing, H., Drogan, D., Pischon, T., Fritsche, A., Prehn, C. P., Adamski, J., Isermann, B., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.080317 · Cited by 72 · see citing works
In Reply—Association of Coffee Consumption With All-Cause and Cardiovascular Disease Mortality
Liu, J., Sui, X., Blair, S. N., & Lavie, C. J. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.003 · Cited by 71 · see citing works
Coffee induces autophagy in vivo
Pietrocola, F., Malik, S. A., Mariño, G., Vacchelli, E., Senovilla, L., Chaba, K., Niso‐Santano, M., Maiuri, M. C., Madeo, F., & Kroemer, G. (2014) · Cell Cycle · doi:10.4161/cc.28929 · Cited by 68 · see citing works
Miranda, A. M., Steluti, J., Fisberg, R. M., & Marchioni, D. M. L. (2017) · Nutrients · doi:10.3390/nu9030276 · Cited by 67 · see citing works
“This cardiovascular protection has been demonstrated in vivo, and can be explained by various mechanisms, including their anti-inflammatory properties [16], the strong antioxidant capacity [17] related to nitric oxide (NO) bioavailability, as well as low-density lipoprotein (LDL) oxidation, and antithrombotic properti…”
BackgroundSolfrizzi, V., and for the Italian Longitudinal Study on Aging Working Group 2, Panza, F., Imbimbo, B. P., D’Introno, A., Galluzzo, L., Gandin, C., Misciagna, G., Guerra, V., Osella, A., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150333 · Cited by 65 · see citing works
French and Mediterranean-style diets: Contradictions, misconceptions and scientific facts-A review
Ndlovu, T., van Jaarsveld, F. P., & Caleb, O. J. (2018) · Food Research International · doi:10.1016/j.foodres.2018.09.020 · Cited by 65 · see citing works
Corrêa, C. L. O., Penha, E. D. M., dos Anjos, M. R., Pacheco, S., Freitas‐Silva, O., Luna, A. S., & Gottschalk, L. M. F. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128045 · Cited by 65 · see citing works
Polyphenols: Potential anti‐inflammatory agents for treatment of metabolic disorders
Zamani‐Garmsiri, F., Emamgholipour, S., Fard, S. R., Ghasempour, G., Jahangard, R., & Meshkani, R. (2021) · Phytotherapy Research · doi:10.1002/ptr.7329 · Cited by 65 · see citing works
Bioavailability of Dietary Polyphenols and the Cardiovascular Diseases
Shivashankara, K. S., & Acharya, S. N. (2010) · The Open Nutraceuticals Journal · doi:10.2174/1876396001003010227 · Cited by 66 · see citing works
“Drinking 8 cups of coffee per day significantly increased serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I and decreased the ratios of LDL to HDL cholesterol [120].”
BackgroundEffect of caffeine contained in a cup of coffee on microvascular function in healthy subjects
Noguchi, K., Matsuzaki, T., Sakanashi, M., Hamadate, N., Uchida, T., Kina-Tanada, M., Kubota, H., Nakasone, J., Sakanashi, M., Ueda, S., et al. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.01.003 · Cited by 63 · see citing works
Sfrp5 correlates with insulin resistance and oxidative stress
Carstensen, M., Herder, C., Kempf, K., Erlund, I., Martin, S., Köenig, W., Sundvall, J., Bidel, S., Kuha, S., Roden, M., et al. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12052 · Cited by 63 · see citing works
Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview
Saeed, M., Naveed, M., Bibi, J., Kamboh, A. A., Phil, L., & Sun, C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1489368 · Cited by 66 · see citing works
“(Kempf et al. 2010; Sang, Kong, and Kim 2015; Cho et al. 2010) Prebiotics In addition to antimicrobial effects coffee has been acknowledged for its prebiotic properties.”
BackgroundCoffee and green tea consumption is associated with insulin resistance in Japanese adults
Pham, N. M., Nanri, A., Kochi, T., Kuwahara, K., Tsuruoka, H., Kurotani, K., Akter, S., Kabe, I., Sato, M., Hayabuchi, H., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.11.008 · Cited by 62 · see citing works
“[40] Kempf K, Herder C, Erlund I, et al.”
BackgroundCoffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women
Boggs, D. A., Rosenberg, L. A., Ruiz-Narváez, E., & Palmer, J. R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29598 · Cited by 62 · see citing works
“However, a recent intervention trial showed favorable effects of coffee on inflammatory markers and lipids but not on glucose metabolism (36).”
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research
Cornelis, M. C., & Hu, F. B. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0052-4 · Cited by 61 · see citing works
“Confirmed metabolite markers of coffee exposure, for example, include mainly methylxanthines and reduced, sulfated, and methylated forms of hydroxycinnamates [108–111], which are coffee-derived metabolites.”
BackgroundMaso, M. D., Boffetta, P., Negri, E., Vecchia, C. L., & Bravi, F. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa177 · Cited by 64 · see citing works
“compounds with potentially beneficial effects, such as insulin-sensitizing (5), antioxidative (6), and antiinflammatory (7).”
BackgroundCorrêa, T. A. F., Monteiro, M. P., Mendes, T. M. N., de Oliveira, D. M., Rogero, M. M., Benites, C. I., Vinagre, C. G. C. D. M., Mioto, B. M., Tarasoutchi, D., Tuda, V. L., et al. (2012) · Plant Foods for Human Nutrition · doi:10.1007/s11130-012-0297-x · Cited by 61 · see citing works
“[26] verified a decrease in these concentrations after a daily intake of 1,200 ml of filtered coffee for one month, twice the amount consumed in our study.”
BackgroundCorrêa, T. A. F., Rogero, M. M., Mioto, B. M., Tarasoutchi, D., Tuda, V. L., César, L. A. M., & Torres, E. A. F. S. (2013) · Nutrition · doi:10.1016/j.nut.2013.01.003 · Cited by 61 · see citing works
“A few studies found a positive association between filtered coffee consumption and an increase in HDL-C concentration [4,30], as we did, which can counterbalance the deleterious effects of increased LDL-C.”
BackgroundInfluentialMachado-Filho, J. A., Correia, A. O., Montenegro, A. B. A., Nobre, M. E. P., Cerqueira, G. S., Neves, K. R. T., Naffah‐Mazzacoratti, M. D. G., Cavalheiro, É. A., Brito, G. A. D. C., & Viana, G. S. D. B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.051 · Cited by 61 · see citing works
Shahmohammadi, H. A., Hosseini, S. A., Hajiani, E., Malehi, A. S., & Alipour, M. (2017) · Hepatitis Monthly · doi:10.5812/hepatmon.45609 · Cited by 61 · see citing works
“In addition to differences in dosages, coffee types, and duration of studies, an explanation for the trials’ findings (37-39) regarding no beneficial effect of coffee on HOMA-IR may be the differences in weight of the studied samples.”
BackgroundMorvaridi, M., Rayyani, E., Jafari, M., Khiabani, A., & Rahimlou, M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00536-x · Cited by 60 · see citing works
“In this regard, some studies indicated that CGA decreased TG, cholesterol, and LDL [60, 65, 67, 68], but increased HDL concentrations [63, 67].”
BackgroundCoffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro
Guo, Y., Niu, K., Okazaki, T., Wu, H., Yoshikawa, T., Ohrui, T., Furukawa, K., Ichinose, M., Yanai, K., Arai, H., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.005 · Cited by 60 · see citing works
“A human clinical trial alsodemonstrated that coffee intake had beneficial effects on subclinical inflammation (Kempf et al., 2010).”
Farrell, T. L., Gómez‐Juaristi, M., Poquet, L., Redeuil, K. M., Nagy, K., Renouf, M., & Williamson, G. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200021 · Cited by 59 · see citing works
Imatoh, T., Tanihara, S., Miyazaki, M., Momose, Y., Uryu, Y., & Une, H. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0136-5 · Cited by 59 · see citing works
“[12] indicated a significant increase in adiponectin levels in response to increased coffee consumption in an intervention trial.”
BackgroundAlamri, O., Albeltagy, R. S., Akabawy, A. M. A., Mahgoub, S., Abdel-Mohsen, D. M., Moneim, A. E. A., & Amin, H. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103996 · Cited by 59 · see citing works
- Authors
- Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Jaakko, T.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- Heinrich Heine University Düsseldorf (DE)
- Finnish Institute for Health and Welfare (FI)
- University of Helsinki (FI)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 91
- Issue
- 4
- Pages
- 950-957
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139329734
- Cited by
- 364
- References
- 40
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 28 · 2020: 29 · 2019: 13 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 37 · 2013: 38 · 2012: 28
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, type 2 diabetes, subclinical inflammation, oxidative stress, caffeine, chlorogenic acid, methylxanthines, IL-18, 8-isoprostane, adiponectin, HDL cholesterol, apolipoprotein A-I, lipid metabolism, glucose metabolism, dietary intervention
- MeSH terms
- Adult, Anti-Inflammatory Agents, Apolipoproteins, Blood Glucose, Caffeic Acids, Caffeine, Chlorogenic Acid, Cholesterol, Coffee, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Lipids, Male, Middle Aged, Risk Factors, Dinoprost, Biomarkers, Single-Blind Method, Interleukin-18, Plant Preparations, Adiponectin
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