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Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance
Abstract
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaa just over one million per yeara rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called a /artemisininsa are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
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Cited by
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Qinghaosu (Artemisinin): The Price of Success
White, N. J. (2008) · Science · doi:10.1126/science.1155165 · Cited by 954
Effectiveness of Antimalarial Drugs
Baird, J. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043207 · Cited by 375
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
Uhlemann, A.-C., Cameron, A., Eckstein-Ludwig, U., Fischbarg, J., Iserovich, P., Zuniga, F. A., East, M., Lee, A., Brady, L., Haynes, R. K., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb947 · Cited by 256
Tougher, S., Ye, Y., Amuasi, J. H., Kourgueni, I. A., Thomson, R., Goodman, C., Mann, A. G., Ren, R., Willey, B. A., Adegoke, C. A., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61732-2 · Cited by 173
Metadata
- Venue
- National Academies Press eBooks
- Publisher
- National Academies Press
- Published
- 2004-09-09
- OpenAlex
- W2411279378
- Cited by
- 227
- References
- 0
- FWCI
- 28.63
- Type
- book
- Language
- en
- Open access
- closed
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