Production of anti-malarial and anti-migraine drugs in tissue culture of Artemisia annua and Tanacetum parthenium
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Dihydroarteannuin B (479) can be converted into artemisinin by cell-free extracts of A. annua.
“It has also been claimed that the 11,13-dihydro analogue of arteannuin B (462), dihydroarteannuin B (479), can be converted into artemisinin by cell free extracts of A. annua [249,312].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [312]
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Self-citationCurrent status of artemisinin and its derivatives as antimalarial drugs
Dhingra, V., Rao, K. V., & Narasu, M. L. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00356-2 · Cited by 241 · see citing works
Vallès, J., Garcia, S., Hidalgo, O., Martín, J., Pellicer, J., Sanz, M., & Garnatje, T. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-385851-1.00015-9 · Cited by 120 · see citing works
Coniferaldehyde derivatives from tissue culture of Artemisia annua and Tanacetum parthenium
Sy, L., & Brown, G. D. (1999) · Phytochemistry · doi:10.1016/s0031-9422(98)00607-4 · Cited by 84 · see citing works
Self-citationRoots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua
Ferreira, J. F. S., & Janick, J. (1996) · Plant Cell, Tissue and Organ Culture · doi:10.1007/bf00048526 · Cited by 75 · see citing works
“, 1992; Brown, 1993; Paniego & Giulietti, 1994) either reported no artemisinin or only trace amounts in callus, cell, or liquid media from these cultures. Martinez & Staba (1988) observed a substantial increase in artemisinin in vitro when shoots developed into rooted plants although, in the same paper, they report th…”
BackgroundAl-Khayri, J. M., Sudheer, W. N., Lakshmaiah, V. V., Mukherjee, E., Nizam, A., Thiruvengadam, M., Nagella, P., Alessa, F. M., Al-Mssallem, M. Q., Adel Abdel-Sabour, R. E. Z. K., et al. (2022) · Molecules · doi:10.3390/molecules27093040 · Cited by 54 · see citing works
“G.D. Brown (1993) reported that artemisinin is produced from the callus grown on an MS medium supplemented with 0.5 mg/L NAA along with 0.5 mg/L BAP, and it is seen that the biosynthetic capabilities for artemisinin production are similar to that of the mature plant [49].”
BackgroundInfluentialArtemisiaannua: Botany, Horticulture, Pharmacology
Ferreira, J., Simon, J. E., & Janick, J. (1996) · Horticultural reviews · doi:10.1002/9780470650622.ch6 · Cited by 50 · see citing works
Application of Hairy Root Culture for Bioactive Compounds Production in Medicinal Plants
Li, C., & Wang, M. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200516155146 · Cited by 36 · see citing works
Anis, M., Alam, P., Ahmad, M. M., Ali, A., Ahmad, J., & Abdin, M. Z. (2014) · Cited by 15 · see citing works
Nieto-Trujillo, A., Lurı́a-Pérez, R., Cruz‐Sosa, F., Zepeda-Gómez, C., González-Pedroza, M. G., Burrola-Aguilar, C., Sunny, A., Correa‐Basurto, J., Guerrero‐Analco, J. A., Monribot‐Villanueva, J. L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157209 · Cited by 1 · see citing works
“…plant material of T. parthenium maintained in vitro was 5 × 10 − 3 % in long-term cell culture, while in leaves from regenerated cultured shoots, it was 1.08%; moreover, in glasshouse-grown plant material, it was 2.77% in apical leaves, 2.3% in mature flowerheads, and 6.5 × 10 − 3 % in roots [32].”
InfluentialAgronomics and Biology of Artemisia annua L.
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813133-6.00002-0 · Cited by 1 · see citing works
- Authors
- Brown, G. D.
- Corresponding author
- Brown, G.D.
- ORCID
- Brown, G.D.
- Venue
- Acta Horticulturae
- Published
- 1993-04
- Issue
- 330
- Pages
- 269-276
- ISSN
- 0567-7572 (ISSN-L)
- 2406-6168
- OpenAlex
- W2591287797
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2014: 1
- FWCI
- 3.78
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- Acta Horticulturae (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
- Keywords
- artemisinin, artemisinin derivatives, antimalarial drugs, antimigraine drugs, Artemisia annua, feverfew, tissue culture, secondary metabolite production
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