It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis
Open accessAbstract
Artemisia sp., especially A. annua and A. afra, have been used for centuries to treat many ailments. While artemisinin is the main therapeutically active component, emerging evidence demonstrates that the other phytochemicals in this genus are also therapeutically active. Those compounds include flavonoids, other terpenes, coumarins, and phenolic acids. Artemisia sp. phytochemicals also improve bioavailability of artemisinin and synergistically improve artemisinin therapeutic efficacy, especially when delivered as dried leaf Artemisia as a tea infusion or as powdered dry leaves in a capsule or compressed into a tablet. Here results from in vitro, and in vivo animal and human studies are summarized and critically discussed for mainly malaria, but also other diseases susceptible to artemisinin and Artemisia sp. including schistosomiasis, leishmaniasis, and trypanosomiasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Analysis of dried leaf samples harvested pre-anthesis over that time had artemisinin and total flavonoid contents of 1.3 ± 0.2% and 0.5 ± 0.09% (w/w), respectively.
“Analysis of dried leaf samples harvested pre-anthesis over that time had artemisinin and total flavonoid contents of 1.3 ± 0.2% and 0.5 ± 0.09% (w/w), respectively.”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Gruessner et al. 2019
In “What in these Artemisia sp. is therapeutically effective?” (page unavailable), the paper reports seven-year averages of 1.28 ± 0.23% artemisinin and 4.63 ± 0.90 mg/g dry-weight flavonoids. These round or convert to the claimed values, but the passage does not establish that the samples were harvested pre-anthesis. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe Weathers lab reported artemisinin levels and total flavonoid content of the SAM cultivar of A. annua propagated at least annually over 7 yrs only by rooted cuttings and grown in different soil locations, in pots in growth chambers and on lighted windowsills.
“The Weathers lab recently reported artemisinin levels and total flavonoid content of the SAM cultivar of A. annua that was propagated at least annually over 7 yrs only by rooted cuttings and grown in different soil locations, in pots in growth chambers and on lighted windowsills (Gruessner et al. 2019).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Gruessner et al. 2019
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
4 retracted
Munyangi, J., Cornet-Vernet, L., Idumbo, M., Lu, C., Lutgen, P., Perronne, C., Ngombe, N., Bianga, J., Mupenda, B., Lalukala, P., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.10.014 · Cited by 40 · see citing works
Self-citationRetractedMunyangi, J., Cornet-Vernet, L., Idumbo, M., Lu, C., Lutgen, P., Perronne, C., Ngombe, N., Bianga, J., Mupenda, B., Lalukala, P., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2018.12.002 · Cited by 38 · see citing works
Self-citationRetractedResponse to Argemi et al. 2019
Cornet-Vernet, L., Munyangi, J., Chen, L., Towler, M. J., & Weathers, P. J. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152943 · Cited by 6 · see citing works
Self-citationRetractedWITHDRAWN: RESPONSE to Gillibert et al. 2019
Cornet-Vernet, L., Munyangi, J., Lu, C., Towler, M. J., & Weathers, P. J. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152980 · Cited by 3 · see citing works
Self-citationRetractedArtemisinin Resistance in <i>Plasmodium falciparum</i> Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424 · see citing works
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., et al. (2013) · Nature · doi:10.1038/nature12876 · Cited by 2,099 · see citing works
General guidelines for methodologies on research and evaluation of traditional medicine
Solimene, U., Anderson, L. M., Briggs, D. G., Cardini, F., Chan, M., Chandra, S., Chang, I., Chaudhury, R. R., Cheraghali, A. M., Fong, H. H. S., et al. (2000) · Cited by 1,025 · see citing works
Flavonoids as anti-inflammatory agents
Serafini, M., Peluso, I., & Raguzzini, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000162x · Cited by 826 · see citing works
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
Hollman, P. C. H., van Trijp, J. M. P., Buysman, M. N. C. P., van der Gaag, M. S., Mengelers, M. J. B., de Vries, J. H. M., & Katan, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01367-7 · Cited by 782 · see citing works
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Straimer, J., Gnädig, N. F., Witkowski, B., Amaratunga, C., Duru, V., Ramadani, A. P., Dacheux, M. A., Khim, N., Zhang, L., Lam, S., et al. (2014) · Science · doi:10.1126/science.1260867 · Cited by 732 · see citing works
Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?
He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015) · Molecules · doi:10.3390/molecules20059183 · Cited by 611 · see citing works
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Mbengue, A., Bhattacharjee, S., Pandharkar, T., Liu, H., Estiu, G. L., Stahelin, R. V., Rizk, S. S., Njimoh, D. L., Ryan, Y., Chotivanich, K., et al. (2015) · Nature · doi:10.1038/nature14412 · Cited by 597 · see citing works
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
Eastman, R. T., & Fidock, D. A. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2239 · Cited by 569 · see citing works
A Review on Anti-Inflammatory Activity of Monoterpenes
Sá, R. D. C. D. S. E., Andrade, L., & de Sousa, D. P. (2013) · Molecules · doi:10.3390/molecules18011227 · Cited by 558 · see citing works
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
Ménard, D., Khim, N., Beghain, J., Adégnika, A. A., Alam, M. S., Amodu, O. K., Rahim-Awab, G., Barnadas, C., Berry, A., Boum, Y., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513137 · Cited by 552 · see citing works
Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532 · see citing works
Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A Review
Rathee, P., Chaudhary, H., Rathee, S., Rathee, D., Kumar, V., & Kohli, K. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809788681029 · Cited by 460 · see citing works
Anti-inflammatory Effects of Flavonoids in Neurodegenerative Disorders
Spagnuolo, C., Moccia, S., & Russo, G. L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.001 · Cited by 458 · see citing works
Mok, S., Ashley, E. A., Ferreira, P. E., Zhu, L., Lin, Z., Yeo, T., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Dhorda, M., et al. (2014) · Science · doi:10.1126/science.1260403 · Cited by 437 · see citing works
A Major Genome Region Underlying Artemisinin Resistance in Malaria
Cheeseman, I. H., Miller, B. A., Nair, S., Nkhoma, S. C., Tan, A., Tan, J. C., Saai, S. A., Phyo, A. P., Moo, C. L., Lwin, K. M., et al. (2012) · Science · doi:10.1126/science.1215966 · Cited by 379 · see citing works
Human malarial disease: a consequence of inflammatory cytokine release
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-85 · Cited by 318 · see citing works
Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism
Witkowski, B., Lelièvre, J., Barragán, M. J. L., Laurent, V., Su, X., Berry, A., & Benoit‐Vical, F. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01636-09 · Cited by 312 · see citing works
Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia
Witkowski, B., Khim, N., Chim, P., Kim, S., Ke, S., Kloeung, N., Chy, S., Socheat, D., Leang, R., Ringwald, P., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01868-12 · Cited by 309 · see citing works
Drug‐resistant malaria: Molecular mechanisms and implications for public health
Petersen, I., Eastman, R., & Lanzer, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.042 · Cited by 304 · see citing works
Development and Fine Structure of the Glandular Trichomes of Artemisia annua L.
Duke, S. O., & Paul, R. N. (1993) · International Journal of Plant Sciences · doi:10.1086/297096 · Cited by 276 · see citing works
Leishmaniasis impact and treatment access
den Boer, M., Argaw, D., Jannin, J. G., & Alvar, J. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03635.x · Cited by 265 · see citing works
Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans
Kohlert, C., van Rensen, I., März, R., Schindler, G., Graefe, E. U., & Veit, M. (2000) · Planta Medica · doi:10.1055/s-2000-8616 · Cited by 250 · see citing works
Isoprene synthesis protects transgenic tobacco plants from oxidative stress
Vickers, C. E., Possell, M., Cojocariu, C., Velikova, V., Laothawornkitkul, J., Ryan, A. C., Mullineaux, P. M., & HEWITT, C. N. (2009) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2009.01946.x · Cited by 247 · see citing works
Juergens, U. R., Engelen, T., Racké, K., Stöber, M., Gillissen, A., & Vetter, H. (2004) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2004.06.002 · Cited by 236 · see citing works
The Origins of Antimalarial-Drug Resistance
Packard, R. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1403340 · Cited by 228 · see citing works
McDougall, B., King, P. J., Wu, B. W., Hostomsky, Z., Reinecke, M. G., & Robinson, W. E. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.140 · Cited by 210 · see citing works
Svensson, & Ashton (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00044.x · Cited by 207 · see citing works
Weathers, P. J., Arsenault, P. R., Covello, P. S., McMickle, A., Teoh, K. H., & Reed, D. W. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9166-0 · Cited by 202 · see citing works
Self-citationTaşdemir, D., Lack, G., Brun, R., Rüedi, P., Scapozza, L., & Perozzo, R. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0600545 · Cited by 198 · see citing works
Fiamegos, Y. C., Kastritis, P. L., Exarchou, V., Haley, H., Bonvin, A. M. J. J., Vervoort, J. J. M., Lewis, K., Hamblin, M. R., & Tegos, G. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018127 · Cited by 192 · see citing works
The Biological Activities of 20 Nature Identical Essential Oil Constituents
van Zyl, R. L., Seatlholo, S. T., van Vuuren, S. F., & Viljoen, A. M. (2006) · Journal of Essential Oil Research · doi:10.1080/10412905.2006.12067134 · Cited by 190 · see citing works
Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures
Liu, K. C.-S., Yang, S., ROBERTS, M. F., Elford, B. C., & Phillipson, J. D. (1992) · Plant Cell Reports · doi:10.1007/bf00236389 · Cited by 189 · see citing works
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites
Rocamora, F., Zhu, L., Liong, K., Dondorp, A. M., Miotto, O., Mok, S., & Bozdech, Z. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006930 · Cited by 179 · see citing works
Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite
Lehane, A. M., & Saliba, K. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-26 · Cited by 175 · see citing works
In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe
Kraft, C., Jenett‐Siems, K., Siems, K., Jakupovic, J., Mavi, S., Bienzle, U., & Eich, E. (2003) · Phytotherapy Research · doi:10.1002/ptr.1066 · Cited by 166 · see citing works
Kim, W.-S., Choi, W. J., Lee, S., Kim, W. J., Lee, D. C., Sohn, U. D., Shin, H., & Kim, W. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2015.19.1.21 · Cited by 165 · see citing works
Terpenes Arrest Parasite Development and Inhibit Biosynthesis of Isoprenoids inPlasmodium falciparum
Goulart, H. R., Kimura, E. A., Peres, V. J., Couto, A. S., Duarte, F. A. A., & Katzin, A. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2502-2509.2004 · Cited by 162 · see citing works
Anti‐Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
Shi, C., Li, H., Yang, Y., & Hou, L. (2015) · Mediators of Inflammation · doi:10.1155/2015/435713 · Cited by 151 · see citing works
Traditional Medicinal Plants and Malaria
Willcox, M., Bodeker, G., Rasoanaivo, P., & Addae-Kyereme, J. (2004) · CRC Press eBooks · doi:10.1201/9780203502327 · Cited by 150 · see citing works
Differential accumulation of isoprenoids in glanded and glandless Artemisia annua L
Tellez, M. R., Canel, C., Rimando, A. M., & Duke, S. O. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00308-8 · Cited by 148 · see citing works
RÄTH, K., Taxis, K., WALZ, G., Gleiter, C. H., Li, S.-M., & Heide, L. E. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.70.128 · Cited by 144 · see citing works
Floral Morphology of Artemisia annua with Special Reference to Trichomes
Janick, J. (1995) · International Journal of Plant Sciences · doi:10.1086/297304 · Cited by 129 · see citing works
Dried Whole Plant Artemisia annua as an Antimalarial Therapy
Elfawal, M. A., Towler, M. J., Reich, N. G., Golenbock, D. T., Weathers, P. J., & Rich, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052746 · Cited by 128 · see citing works
Self-citationEfferth, T., Herrmann, F., Tahrani, A., & Wink, M. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.06.008 · Cited by 128 · see citing works
Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency
Zhang, M., Gallego‐Delgado, J., Fernández-Arias, C., Waters, N. C., Rodrı́guez, A., Tsuji, M., Wek, R. C., Nussenzweig, V., & Sullivan, W. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.005 · Cited by 125 · see citing works
Elfawal, M. A., Towler, M. J., Reich, N. G., Weathers, P. J., & Rich, S. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413127112 · Cited by 124 · see citing works
Self-citationPlasmodium falciparum: multifaceted resistance to artemisinins
Paloque, L., Ramadani, A. P., Mercereau‐Puijalon, O., Augereau, J., & Benoit‐Vical, F. (2016) · Malaria Journal · doi:10.1186/s12936-016-1206-9 · Cited by 117 · see citing works
Titulaer, H. A. C., Zuidema, J., Kager, P. A., Wetsteyn, J. C. F. M., Lugt, C. B., & Merkus, F. W. H. M. (1990) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1990.tb07030.x · Cited by 116 · see citing works
Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua
Lubbe, A., Seibert, I., Klimkait, T., & van der Kooy, F. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.03.024 · Cited by 114 · see citing works
Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways
Wang, K. S., Li, J., Wang, Z., Mi, C., Ma, J., Piao, L. X., Xu, G. H., Li, X., & Jin, X. (2016) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2016.1267744 · Cited by 109 · see citing works
Gathirwa, J. W., Rukunga, G. M., Njagi, E. N. M., Omar, S. A., Mwitari, P., Guantai, A. N., Tolo, F. M., Kimani, C. W., Muthaura, C. N., Kirira, P., et al. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.09.021 · Cited by 102 · see citing works
de Magalhães, P. M., Dupont, I. E., Hendrickx, A., Joly, A., Raas, T., Dessy, S., Sergent, T., & Schneider, Y. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.195 · Cited by 98 · see citing works
Antimalarials in the Treatment of Schistosomiasis
Keiser, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212801327293 · Cited by 95 · see citing works
Deepa, G., Fuehrer, H., Starzengrüber, P., Swoboda, P., Khan, W. A., Reismann, J. A. B., Mueller, M. S. K., Chiba, P., & Noedl, H. (2012) · Parasitology Research · doi:10.1007/s00436-011-2763-z · Cited by 95 · see citing works
Suberu, J., Gorka, A. P., Jacobs, L., Roepe, P. D., Sullivan, N., Barker, G. C., & Lapkin, A. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080790 · Cited by 92 · see citing works
Wang, Z., Wang, Y., Cabrera, M., Zhang, Y., Gupta, B., Wu, Y., Kemirembe, K., Hu, Y., Liang, X., Brashear, A., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01255-15 · Cited by 85 · see citing works
Moura, I. C., Wunderlich, G., Uhrig, M. L., Couto, A. S., Peres, V. J., Katzin, A. M., & Kimura, E. A. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2553-2558.2001 · Cited by 85 · see citing works
Anti-Inflammatory Effects ofArtemisiaLeaf Extract in Mice with Contact DermatitisIn VitroandIn Vivo
Yun, C., Jung, Y., Chun, W., Yang, B., Ryu, J., Lim, C., Kim, J.-H., Kim, H., & Cho, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/8027537 · Cited by 80 · see citing works
Daddy, N. B., Kalisya, L. M., Bagire, P. G., Watt, R. L., Towler, M. J., & Weathers, P. J. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.04.006 · Cited by 79 · see citing works
Self-citationLwin, K. M., Phyo, A. P., Tärning, J., Hanpithakpong, W., Ashley, E. A., Lee, S. J., Cheah, P., Singhasivanon, P., White, N. J., Lindegårdh, N., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05877-11 · Cited by 75 · see citing works
Zhu, C., Xiong, Z., Chen, X., Peng, F., Hu, X., Chen, Y., & Wang, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035125 · Cited by 74 · see citing works
Liu, N. Q., Cao, M., Frédérich, M., Choi, Y. H., Verpoorte, R., & van der Kooy, F. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.020 · Cited by 74 · see citing works
Dried-leaf Artemisia annua : A practical malaria therapeutic for developing countries?
Weathers, P. J. (2014) · World Journal of Pharmacology · doi:10.5497/wjp.v3.i4.39 · Cited by 72 · see citing works
Self-citationLi, Y., Guo, Y. H., Yang, Q., Weng, X., Yang, L., Wang, Y., Chen, Y., Zhang, D., Li, Q., Liu, X.-C., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.04.005 · Cited by 69 · see citing works
Natalang, O., Bischoff, E., Deplaine, G., Proux, C., Dillies, M., Sismeiro, O., Guigon, G., Bonnefoy, S., Patarapotikul, J., Mercereau‐Puijalon, O., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-388 · Cited by 68 · see citing works
The activity of Artemisia spp. and their constituents against Trypanosomiasis
Naß, J., & Efferth, T. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.002 · Cited by 68 · see citing works
van der Kooy, F., & Sullivan, S. E. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.08.021 · Cited by 66 · see citing works
Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts
Czechowski, T., Rinaldi, M. A., Famodimu, M. T., van Veelen, M., Larson, T. R., Winzer, T., Rathbone, D. A., Harvey, D., Horrocks, P., & Graham, I. A. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00984 · Cited by 61 · see citing works
Development of artemisinin resistance in malaria therapy
Naß, J., & Efferth, T. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104275 · Cited by 56 · see citing works
Weathers, P. J., Elfawal, M. A., Towler, M. J., Acquaah-Mensah, G. K., & Rich, S. M. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.03.037 · Cited by 54 · see citing works
Self-citationDonno, A. D., Grassi, T., Idolo, A., Guido, M., Papadia, P., Caccioppola, A., Villanova, L., Merendino, A., Bagordo, F., & Fanizzi, F. P. (2012) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2012.07.008 · Cited by 53 · see citing works
Concentration and Time Dependency of Artemisinin Efficacy Against Plasmodium falciparum in Vitro
Alin, M. H., & Björkman, A. (1994) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1994.50.771 · Cited by 53 · see citing works
Degradation and ecotoxicity of the biomedical drug artemisinin in soil
Sjøholm, K. K., Nina Cedergreen, G., Jensen, J., & Hansen, H. C. B. (2009) · Environmental Toxicology and Chemistry · doi:10.1897/08-153r.1 · Cited by 48 · see citing works
Gordi, T., Hai, T. N., Hoai, N. M., Thyberg, M., & Ashton, M. (2000) · European Journal of Clinical Pharmacology · doi:10.1007/s002280000179 · Cited by 43 · see citing works
The Content of Artemisinin in theArtemisia annuaTea Infusion
van der Kooy, F., & Verpoorte, R. (2011) · Planta Medica · doi:10.1055/s-0030-1271065 · Cited by 40 · see citing works
Erdman, L., Finney, C. A. M., Liles, W. C., & Kain, K. C. (2008) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2008.08.006 · Cited by 40 · see citing works
Mesa, L. E., Vasquez, D., Lutgen, P., Vélez, I. D., Restrepo, A. M., Ortiz, I., & Robledo, S. M. (2017) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0457-2016 · Cited by 39 · see citing works
Self-citationModulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2α, which Is Relevant during Hypoxia
Blaustein, M., Pérez-Munizaga, D., Sánchez, M. A., Urrutia, C., Grande, A., Risso, G., Srebrow, A., Alfaro, J., & Colman‐Lerner, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069668 · Cited by 36 · see citing works
Weathers, P. J., & Towler, M. J. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.08.033 · Cited by 36 · see citing works
Self-citationMoyo, P., Botha, M. E., Nondaba, S. H., Niemand, J., Maharaj, V. J., Eloff, J. N., Louw, A. I., & Birkholtz, L. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.036 · Cited by 36 · see citing works
Jin, H., Xu, Z., Cui, K., Zhang, T., Lü, W., & Huang, J. Y. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.01.017 · Cited by 35 · see citing works
Ogwang, P., Ogwal, J. J., Kasasa, S., Olila, D., Ejobi, F., Kabasa, D., & Obua, C. (2012) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v11i3.14 · Cited by 34 · see citing works
Wei, S., Ji, H., Yang, B., Ma, L., Bei, Z., Li, X., Dang, H., Yang, X., Liu, C., Wu, X., et al. (2015) · Malaria Journal · doi:10.1186/s12936-015-0929-3 · Cited by 32 · see citing works
Li, J., Zhang, C., Gong, M., & Wang, M. (2018) · Phytotherapy Research · doi:10.1002/ptr.6077 · Cited by 32 · see citing works
Penna-Coutinho, J., Aguiar, A. C., & Krettli, A. U. (2018) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760180279 · Cited by 32 · see citing works
Plasmodium falciparum growth is arrested by monoterpenes from eucalyptus oil
Su, V., King, D. J., Woodrow, I. E., McFadden, G. I., & Gleadow, R. M. (2008) · Flavour and Fragrance Journal · doi:10.1002/ffj.1880 · Cited by 31 · see citing works
Desrosiers, M. R., & Weathers, P. J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.06.041 · Cited by 31 · see citing works
Self-citationOgwang, P. E. (2011) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2011/392 · Cited by 30 · see citing works
Desrosiers, M. R., & Weathers, P. J. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.08.038 · Cited by 29 · see citing works
Self-citationAntiplasmodial Activity of the Ethnobotanical Plant Cassia fistula
Grace, M. H., Lategan, C. A., Graziose, R., Smith, P. J., Raskin, I., & Lila, M. A. (2012) · Natural Product Communications · doi:10.1177/1934578x1200701002 · Cited by 27 · see citing works
Zammarchi, L., Antonelli, A., Lapini, M., Prato, M. G., Farese, A., Rossolini, G. M., & Bartoloni, A. (2016) · Journal of Travel Medicine · doi:10.1093/jtm/taw044 · Cited by 26 · see citing works
Silva, L. F. R. E., de Magalhães, P. M., Costa, M. R. F., Alecrim, M. D. G. C., Chaves, F. C. M., Hidalgo, A. D. F., Pohlit, A. M., & Vieira, P. P. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000700004 · Cited by 24 · see citing works
Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers
Birgersson, S., Toi, P. V., Truong, N. T., Dung, N. T., Ashton, M., Hien, T. T., Äbelö, A., & Tärning, J. (2016) · Malaria Journal · doi:10.1186/s12936-016-1134-8 · Cited by 22 · see citing works
Hien, T. T., Hanpithakpong, W., Truong, N. T., Dung, N. T., Toi, P. V., Farrar, J., Lindegårdh, N., Tärning, J., & Ashton, M. (2011) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.04.017 · Cited by 21 · see citing works
Mouton, J., Jansen, O., Frédérich, M., & van der Kooy, F. (2013) · Planta Medica · doi:10.1055/s-0032-1328324 · Cited by 20 · see citing works
Moriyasu, T., Nakamura, R., Deloer, S., Senba, M., Kubo, M., Inoue, M., Culleton, R. L., & Hamano, S. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006197 · Cited by 19 · see citing works
Niaré, K., Dara, A., Sagara, I., Sissoko, M. S., Guindo, C. O., Cissé, N. H., Coulibaly, C. O., Ringwald, P., Benoit‐Vical, F., Berry, A., et al. (2016) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.15-0503 · Cited by 17 · see citing works
Argemi, X., Hansmann, Y., Gaudart, J., Gillibert, A., Caumes, É., Jauréguiberry, S., & Meyer, N. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.027 · Cited by 12 · see citing works
Bischoff, S. R., Tsai, S. Q., Hardison, N. E., York, A., Freking, B. A., Nonneman, D., Rohrer, G. A., & Piedrahita, J. A. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-252 · Cited by 10 · see citing works
Gillibert, A., Jauréguiberry, S., Hansmann, Y., Argemi, X., Landier, J., Caumes, É., & Gaudart, J. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152981 · Cited by 10 · see citing works
Artemisia annua and Artemisia afra Essential Oils and Their Therapeutic Potential
Desrosiers, M. R., Towler, M. J., & Weathers, P. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-16546-8_6 · Cited by 10 · see citing works
Self-citationLagarce, L., Lerolle, N., Asfar, P., Govic, Y. L., Lainé‐Cessac, P., & de Gentile, L. (2016) · Journal of Travel Medicine · doi:10.1093/jtm/taw049 · Cited by 8 · see citing works
Sowunmi, A., Akano, K. O., Ntadom, G. N., Ayede, A. I., Oguche, S., Agomo, C. O., Okafor, H. U., Watila, I. M., Meremikwu, M. M., Ogala, W. N., et al. (2017) · Chemotherapy · doi:10.1159/000449366 · Cited by 8 · see citing works
Actividad de infusiones de Artemisia annua sobre epimastigotes de Trypanosoma cruzi
Berrizbeitia, M., Cariaco, Y., Buiza, J. I., & Lutgen, P. (2016) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2016.09.011 · Cited by 6 · see citing works
Self-citationArtemisinin the Nobel Molecule
Weathers, P. J., Cambra, H. M., Desrosiers, M. R., Rassias, D., & Towler, M. J. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63931-8.00005-9 · Cited by 6 · see citing works
Self-citationGbotosho, G. O., Sowunmi, A., Okuboyejo, T. M., & Happi, C. T. (2011) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmr045 · Cited by 5 · see citing works
In vivo trials on the therapeutic effects of encapsulated Artemisia annua and Artemisia afra
Tchandema, C. K., Lubumbashi, RDCongo, & Lutgen, P. (2016) · GLOBAL JOURNAL FOR RESEARCH ANALYSIS · Cited by 3 · see citing works
Self-citationZaid, O. I., Majid, R. A., Hasidah, M. S., Sabariah, M. N., Rahi, S., & Basir, R. (2016) · PubMed · Cited by 3 · see citing works
Activity of Artemisia annua infusions on epimastigotes of Trypanosoma cruzi
Berrizbeitia, M., Cariaco, Y., Buiza, J. I., & Lutgen, P. (2017) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2017.04.007 · Cited by 2 · see citing works
Self-citationLettre à la rédaction « Tisane magique ou bouillon de onze heures ? »
Danis, M. (2019) · Bulletin de la Société de pathologie exotique · doi:10.3166/bspe-2019-0069 · Cited by 2 · see citing works
Epelboin, L. (2019) · Bulletin de la Société de pathologie exotique · doi:10.3166/bspe-2018-0069 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 117 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ashraf, M. V., Pant, S., Khan, M. A. H., Shah, A. A., Siddiqui, S., Jeridi, M., Alhamdi, H. W. S., & Ahmad, S. (2023) · Pharmaceuticals · doi:10.3390/ph16060881 · Cited by 117 · see citing works
Trendafilova, A. B., Moujir, L., Sousa, P. M. C., & Seca, A. M. L. (2020) · Foods · doi:10.3390/foods10010065 · Cited by 84 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
Self-citationDesrosiers, M. R., Mittleman, A., & Weathers, P. J. (2020) · Biomolecules · doi:10.3390/biom10020254 · Cited by 46 · see citing works
Self-citationChebbac, K., Ouaritini, Z. B., Moussaoui, A. E., Chalkha, M., Lafraxo, S., Jardan, Y. A. B., Nafidi, H., Bourhia, M., & Guemmouh, R. (2023) · Life · doi:10.3390/life13030807 · Cited by 41 · see citing works
14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer
Zhang, Y., Yan, M., Yu, Y., Wang, J., Jiao, Y., Zheng, M., & Zhang, S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01420-w · Cited by 26 · see citing works
Saifi, S., Ashraf, A., Hasan, G. M., Shamsi, A., & Hassan, M. I. (2024) · Fitoterapia · doi:10.1016/j.fitote.2023.105811 · Cited by 25 · see citing works
Advances in schistosomiasis drug discovery based on natural products.
Mtemeli, F. L., Ndlovu, J., Mugumbate, G., Makwikwi, T., & Shoko, R. (2022) · All Life · doi:10.1080/26895293.2022.2080281 · Cited by 21 · see citing works
Artemisinin as a therapeutic vs. its more complex Artemisia source material
Weathers, P. J. (2022) · Natural Product Reports · doi:10.1039/d2np00072e · Cited by 19 · see citing works
Self-citationIn vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts
Taljaard, L., Probst, A., Tornow, R., Keiser, J., Haynes, R. K., & van der Kooy, F. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100279 · Cited by 17 · see citing works
Learning about Science & Pseudoscience as Critical Consumers
Beer, J. J. D., & Wyk, B.-E. V. (2022) · The American Biology Teacher · doi:10.1525/abt.2022.84.8.488 · Cited by 16 · see citing works
Phytochemical diversity and pharmacological effects of sesquiterpenes from Artemisia spp.
Rezaei, A., Emami, S. A., & Akaberi, M. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-09962-8 · Cited by 16 · see citing works
Shi, H., Wang, Z., Xu, F., Li, J., Li, J., & Wang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314903 · Cited by 14 · see citing works
Emergence of Ethnomedical COVID-19 Treatment: A Literature Review
Aprilio, K., & Wilar, G. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s327986 · Cited by 13 · see citing works
Weathers, P. J., Towler, M. J., Kiani, B. H., Dolivo, D., & Dominko, T. (2024) · Molecules · doi:10.3390/molecules29092107 · Cited by 10 · see citing works
Self-citationThe Antiviral and Antimalarial Prodrug Artemisinin from the Artemisia Species: A Review
Das, G., Shin, H.-S., & Patra, J. K. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46110718 · Cited by 10 · see citing works
Effect of Silica Based Nanoparticles against Plasmodium falciparum and Leishmania infantum parasites
Tsamesidis, I., Lymperaki, E., Egwu, C. O., Pouroutzidou, G. K., Kazeli, K., Reybier, K., Bourgeade‐Delmas, S., Valentin, A., & Kontonasaki, E. (2021) · Journal of Xenobiotics · doi:10.3390/jox11040011 · Cited by 10 · see citing works
Roesch, C., Ashraf, K., Vantaux, A., Marin, A. A., Maher, S. P., Franetich, J., Kloeung, N., Ke, S., Vo, H. T. M., Barale, J.-C., et al. (2025) · Malaria Journal · doi:10.1186/s12936-025-05375-w · Cited by 8 · see citing works
Artemisia Species and Their Active Constituents for Treating Schistosomiasis
Taljaard, L., Haynes, R. K., & van der Kooy, F. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00407-5 · Cited by 8 · see citing works
Vasilyevich, K. G., Kryukov, L. A., Shemesh‐Mayer, E., & Kamenetsky, R. (2021) · Plants · doi:10.3390/plants11010006 · Cited by 5 · see citing works
Silva, E. D. O., Marreto, R. N., da Conceição, E. C., & Bara, M. T. F. (2021) · Revista Fitos · doi:10.32712/2446-4775.2021.1063 · Cited by 4 · see citing works
Mikaeili, A., Ghasemi, S., Salmani, S., Modarresi, M., & Mojarrab, M. (2023) · Sālnāmah va āmār. · doi:10.61186/jbums.30.1.33 · Cited by 2 · see citing works
Matshe, W. M. R., Mvango, S., Malabi, R., Tantoh, A. L. A., Andraos, C., Famuyide, I. M., McGaw, L. J., Baijnath, S., Pilcher, L. A., & Balogun, M. O. (2025) · Applied Research · doi:10.1002/appl.70041 · Cited by 1 · see citing works
Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii
Orababa, O. Q., Furner-Pardoe, J., Gale, A., Anonye, B. O., Ratcliff, J., Reddy, N., Maset, R. G., Harrington, N. E., Subhaskaran, S., Holden, S. E., et al. (2026) · mSphere · doi:10.1128/msphere.00494-26 · Cited by 1 · see citing works
Vandenschrick, M. M. (2023) · Revista Perfiles Económicos · doi:10.22370/pe.2022.13.3444
Gruessner, B. M., Cornet-Vernet, L., Desrosiers, M. R., Lutgen, P., Towler, M. J., & Weathers, P. J. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-09915-1
Self-citation"The Review about the Kinetics of Monoterpenes Formation in Plants of Sort Artemisia"
Vasilyevich, K. G. (2024) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2024.55.008655
In vitro antischistosomal activity of Artemisia species
Malan, D., Niekerk, S. E. V., Häberli, C., Keiser, J., & van der Kooy, F. (2025) · Acta Tropica · doi:10.1016/j.actatropica.2025.107535
Makoana, K. M., Naidoo, C. M., Zubair, M., Motshudi, M. C., & Mkolo, N. M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320415
Mikaeili, A., Ghasemi, S., Ghiasvand, N., Valadbeigi, A., & Mojarrab, M. (2024) · “Polytechnic Bulletin” Series “Intellect Innovations Investments” · doi:10.61882/goums.26.4.70
Phytochemical changes in clonal Artemisia annua L. grown in the US
Towler, M. J., & Weathers, P. J. (2026) · Acta Horticulturae · doi:10.17660/actahortic.2026.1462.8
Self-citation
- Authors
- Gruessner, B. M., Cornet-Vernet, L., Desrosiers, M. R., Lutgen, P., Towler, M. J., & Weathers, P. J.
- Affiliations
- Worcester Polytechnic Institute (US)
- Corresponding author
- Weathers, P. J.
- Venue
- Phytochemistry Reviews
- Published
- 2019-09-19
- Volume
- 18
- Issue
- 6
- Pages
- 1509-1527
- ISSN
- 1568-7767 (ISSN-L)
- 1572-980X
- PMC
- PMC8078015
- OpenAlex
- W2973385660
- Cited by
- 31
- References
- 117
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Phytochemistry Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Complementary and Alternative Medicine (NIH-2R15AT008277-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Keywords
- Artemisia, artemisinin, Artemisia annua, Artemisia afra, phytochemicals, flavonoids, terpenes, coumarins, phenolic acids, synergistic drug efficacy, malaria, schistosomiasis, leishmaniasis, trypanosomiasis, herbal medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
