The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation
Open accessAbstract
Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to non-alcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokines-including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.
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Citations
Cites
Human Fatty Liver Disease: Old Questions and New Insights
Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089
Hepatokines: unlocking the multi-organ network in metabolic diseases
Iroz, A., Couty, J.-P., & Postic, C. (2015) · Diabetologia · doi:10.1007/s00125-015-3634-4 · Cited by 111
Seven, A., Güzel, S., Seymen, O., Civelek, S., Bolayırlı, M., Uncu, M., & Burçak, G. (2004) · Yonsei Medical Journal · doi:10.3349/ymj.2004.45.4.703 · Cited by 109
Cited by
Escribano-Lopez, I., Diaz-Morales, N., Iannantuoni, F., Lopez-Domenech, S., de Marañon, A. M., Abad-Jimenez, Z., Bañuls, C., Rovira-Llopis, S., Herance, J. R., Rocha, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34251-8 · Cited by 71
Zhang, D., Xie, T., & Leung, P. S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495395 · Cited by 65
Metadata
- Authors
- Mohamed, J., H., N. N. A., H., Z. A., & B., B. S.
- Venue
- Sultan Qaboos University Medical Journal
- Publisher
- Sultan Qaboos University
- Published
- 2016-05-15
- Volume
- 16
- Issue
- 2
- Pages
- e132-141
- ISSN
- 2075-051X (ISSN-L)
- 2075-0528
- OpenAlex
- W2360439189
- Cited by
- 473
- References
- 3
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Mohamed, J., H., N. N. A., H., Z. A., & B., B. S. (2016). Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation. Sultan Qaboos University Medical Journal. https://doi.org/10.18295/squmj.2016.16.02.002
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