Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma

Seven, Arzu; Güzel, Sava; Seymen, Oktay; Civelek, Sabiha; Bolayırlı, Murat; Uncu, Murat; Burçak, Gülden

doi:10.3349/ymj.2004.45.4.703

Cited by 109Antioxidant Activity and Oxidative StressNatural Antidiabetic Agents StudiesExercise and Physiological Responses

Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma

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Seven, Arzu, Güzel, Sava, Seymen, Oktay, Civelek, Sabiha, Bolayırlı, Murat, Uncu, Murat, Burçak, Gülden·2004·Yonsei Medical Journal

DOI 10.3349/ymj.2004.45.4.703

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Abstract

This experimental study was designed to investigate the effects of vitamin E supplementation, especially on lipid peroxidation and antioxidant status elements 3/4 namely, glutathione (GSH), CuZn superoxide dismutase (CuZn SOD), and glutathione peroxidase (GSH Px), both in blood and liver tissues of streptozotocin (STZ) diabetic rats. The extent to which blood can be used to reflect the oxidative stress of the liver is also investigated. In diabetic rats, plasma lipid peroxide values were not significantly different,from control,whereas erythrocyte CuZn SOD (p < 0.01), GSH Px (p < 0.001) activities and plasma vitamin E levels (p < 0.001), were significantly more elevated than controls. Vitamin E supplementation caused significant decreases of erythrocyte GSH level (p < 0.01) in control rats and of erythrocyte GSH Px activity (p < 0.05) in diabetic rats. Liver findings revealed significantly higher lipid peroxide (p < 0.001) and vitamin E (p < 0.01) levels and lower GSH (p < 0.001), CuZn SOD (p < 0.001) and GSH Px (p < 0.01) levels in diabetic rats. A decreased hepatic lipid peroxide level (p < 0.01) and increased vitamin E/lipid peroxide ratio (p < 0.001) were observed in vitamin E supplemented, diabetic rats. A vitamin E supplementation level which did not cause any increase in the concentration of the vitamin in the liver or blood, was sufficient to lower lipid peroxidation in the liver. Vitamin E/lipid peroxide ratio is suggested as an appropriate index to evaluate the efficiency of vitamin E activity,independent of tissue lipid values. Further, the antioxidant components GSH, GSH Px and CuZn SOD and the relationships among them, were affected differently in the liver and blood by diabetes or vitamin E supplementation.

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Vitamin E decreases hepatic peroxide level in diabetic rats.
“Vitamin E has been shown to decrease the hepatic peroxide level in diabetic rats.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Seven et al. 2004

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Background
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Background
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Hepatoprotective effects of vitamin E against hexachlorobenzene-induced hepatotoxicity and oxidative stress in rats: histological, biochimical and antioxidant status changes
Chalouati, H., Sâad, M. M. B., & Payrastre, L. (2018) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2018.1506847 · Cited by 14 · see citing works
“affected ALT, AST and ALP activities, which may be do to disturbance of their biosynthesis with alteration in the permeability of liver membrane (Seven et al. 2004).”
BackgroundInfluential
Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats
Soliman, A. M., Abu‐El‐Zahab, H. S. H., & Alswiai, G. A. (2013) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(13)60058-9 · Cited by 13 · see citing works
Protective Effects of Bryonia multiflora Extract on Pancreatic Beta Cells, Liver and Kidney of Streptozotocin-Induced Diabetic Rats: Histopathological and Immunohistochemical Investigations
Uyar, A., Yaman, T., Keleş, Ö. F., Alkan, E. E., Çelik, İ., & Yener, Z. (2017) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.51.3s.57 · Cited by 12 · see citing works
Effect of Vitamin C and / or Vitamin E on Kidney , Liver and brain Functions of Streptozotocin-Induced Diabetic Rats
Soliman, G. Z. A. (2013) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0001642 · Cited by 12 · see citing works
The potential role of combined antioxidant treatment on pancreas of STZ-diabetic mice
Kaçar, A. K., & Bolkent, Ş. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.08.012 · Cited by 11 · see citing works
Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats
Fakher, S., Djalali, M., Tabei, K., Zeraati, H., Javadi, E., Sadeghi, M. R., Mostafavi, E., & Fatehi, F. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 10 · see citing works
Synthetic Insecticide Fipronil Induced Over Gene Expression, DNA and Liver Damage in Female Rats: The Protective Role of Fish Oil
Refaie, A. A., Ramadan, A., Sabry, N. M., & Khalil, W. K. B. (2021) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2021.58506.3264 · Cited by 10 · see citing works
Regulation of Glutathione S-Transferase Mu with type 1 diabetes and its regulation with antioxidants
Sadı, G., Kartal, D. İ., & Güray, T. (2013) · Turkish Journal of Biochemistry · doi:10.5505/tjb.2013.96720 · Cited by 9 · see citing works
“The beneficial effects of antioxidants in the treatment of diabetes have been shown by several investigators [19-23].”
BackgroundResult
Age and Sex Differences in the Association between Serum Vitamin E Levels and Depressive Symptoms: Korea National Health and Nutrition Examination Survey
Jeong, H., Oh, J., Son, N., & Lee, S. (2023) · Nutrients · doi:10.3390/nu15081915 · Cited by 9 · see citing works
Antioxidant Potential of Non-Extractable Fractions of Dried Persimmon (Diospyros kaki Thunb.) in Streptozotocin-Induced Diabetic Rats
Mochida, N., Matsumura, Y., Kitabatake, M., Ito, T., Kayano, S.-I., & Kikuzaki, H. (2022) · Antioxidants · doi:10.3390/antiox11081555 · Cited by 8 · see citing works
“However, conflicting findings have been reported in diabetic rats; namely, increases, decreases, and no changes in antioxidant enzyme activities [21,39,42,44,45].”
Background
Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta
Petrović, A., Madić, V., Stojanović, G., Zlatanović, I. G., Zlatković, B. K., Vasiljevic, P. J., & Đorđević, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117032 · Cited by 9 · see citing works
Effects of soybean isoflavone extract on the plasma lipid profiles and antioxidant enzyme activity in streptozotocin-induced diabetic rats
Shim, J. Y., Kim, Y. J., & Lee, H.-S. (2008) · Nutrition Research and Practice · doi:10.4162/nrp.2008.2.4.218 · Cited by 8 · see citing works
“The TBARS levels of the liver and kidney tissues in the diabetic control group were significantly higher than that in the normal control group, which were consistent with the results of previous studies (Kaleem et al., 2006; Lee, 2006; Seven et al., 2004).”
Result
Hydroalcoholic Extract of Terminalia arjuna:A Potential Hepatoprotective Herb
Uthirapathy, S., Rajamanickam, G. V., Dubey, G., et al. (2007) · Journal of Biological Sciences · doi:10.3923/jbs.2007.255.262 · Cited by 8 · see citing works
α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models
Takitani, K., INOUE, K., Koh, M., Miyazaki, H., Kishi, K., Inoue, A., & Tamai, H. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.380 · Cited by 7 · see citing works
Evaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male Rats
Ahmida (2010) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2010.167.176 · Cited by 7 · see citing works
“The antioxidant activity or the inhibition in the generation of free radical is important in providing protection against hepatic damage (Shahjahan et al., 2004).”
Background
Ameliorative Effect of α-Tocopherol and Selenium on Effects of Malathion on Plasmatic Biochemical Indices and Lesions in the Liver of Rats
Al-Othman, A. M., ALOthman, Z. A., Eldesoky, G. E., et al. (2012) · Current Pharmaceutical Analysis · doi:10.2174/1573412911208020214 · Cited by 7 · see citing works
“It has been previously reported that during liver damage there was an observed decrease in antioxidant defenses in the liver [31].”
Background
Hepatoprotective Effect of the Aqueous Extract of Camellia sinensis Against Methotrexate-induced Liver Damage in Rats
Jwied, A. H. (2017) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol18iss2pp73-79 · Cited by 7 · see citing works
Therapeutic Potential of Virgin Coconut Oil in Ameliorating Diabetes Mellitus and Hepatotoxicity Using Rattus Norvegicus as Case Study
Okpiabhele, A. O., Nw, E. A. C., & Abu, O. D. (2018) · Asian Journal of Biological Sciences · doi:10.3923/ajbs.2018.138.144 · Cited by 6 · see citing works
Integrating in silico molecular docking, ADMET analysis of C.verticillata with diabetic markers and in vitro anti-inflammatory activity
Maheswari, A., & Desire, S. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00576-z · Cited by 6 · see citing works
Pengaruh pemberian jus mangga terhadap profil lipid dan malondialdehyde pada tikus yang diberi minyak jelantah
Zaki, I., Johan, A., & Nyoman Suci, W. (2016) · Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) · doi:10.14710/jgi.3.2.108-115 · Cited by 6 · see citing works
Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates
Zarei, M., Fakher, S., Tabei, K., Javanbakht, M., Derakhshanian, H., Farahbakhsh-Farsi, P., Sadeghi, M. R., Mostafavi, E., & Djalali, M. (2015) · Singapore Medical Journal · doi:10.11622/smedj.2015102 · Cited by 5 · see citing works
“In such situations, supplementation with antioxidants such as vitamins A, C and E may be beneficial.(4) Vitamin E, a hydrophobic antioxidant found in lipoproteins and cellular membranes, can provide effective protection against lipid peroxyl radicals.”
Background
Preliminary Studies on the Potential Antioxidant and Antidiabetic Activities of Sargassum polycystum C. Agardh (Phaeophyceae, Ochrophyta)
(2022) · Jordan Journal of Biological Sciences · doi:10.54319/jjbs/150314 · Cited by 5 · see citing works
"Methanol Fraction of Ethanol Extract of Dialium Guineense Stem Bark Mitigates STZ-Induced Oxidative Stress in Rat Liver"
Abu, O. D. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.51.008085 · Cited by 5 · see citing works
Can ursolic acid be beneficial against diabetes in rats?
Bacanli, M. G., DİLSİZ, S. A., Anlar, H. G., et al. (2018) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2017-0289 · Cited by 5 · see citing works
“Seven et al. [25] demonstrated that SOD and GSH-Px enzyme activities and GSH levels were decreased in the livers of STZ-induced diabetic rats compared to their controls.”
Background
Effect of administration of Ehretia anacua aqueous extract on blood glucose level in alloxan - induced diabetic rat
Oyelade, W. A., Ademola, O. J., & FAJILADE, O. T. (2021) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2021.11.2.0068 · Cited by 4 · see citing works
“(Seven et al., 2004).”
Morin (2′,3,4′,5,7-Pentahydroxyflavon) Antioxidant Effect in Streptozotocin-Induced Diabetic Rat Brain and Heart Tissues
Beyatlı, A., Peker, E. G. G., Gül, N., et al. (2022) · Journal of Anatolian Environmental and Animal Sciences · doi:10.35229/jaes.1103000 · Cited by 4 · see citing works
Effect of Selenium and Bee Pollen Against Immunotoxicity and Hepatotoxicity Induced by Cadmium in Male Albino Rats.
Shater, A.-E. R. E., Ali, R. A., & Ahlam, R. (2019) · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology · doi:10.21608/eajbsc.2019.28688 · Cited by 4 · see citing works
Evaluation of Citral and Green Silver Nanoparticles From Cymbopogon citratus Extract on Biochemical Profile and Nrf2 Gene Expression in Liver Tissue of Type 2 Diabetic Rats
Khatinasab, S., Kazemipour, N., Noorbakhsh, M. F., Nazıfı, S., Faraji, M., & Ahmadi, N. (2025) · BioMed Research International · doi:10.1155/bmri/9266092 · Cited by 4 · see citing works
Hepatoprotective potential of Ocimum gratissimum on ethanol induced hepatotoxicity in albino rats
Saramma, G., Macharia, J. C., Kwape, K., et al. (2012) · Cited by 3 · see citing works
The Beneficial Effects of Actinomycetales Immune Modulators in the Pancreas of Diabetic Rats
Khordadmehr, M., Ghaderi, S., Abbasi, M. M., et al. (2020) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2021.035 · Cited by 3 · see citing works
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL INSTITUTO DE CIÊNCIAS BÁSICAS DA SAÚDE PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS: FISIOLOGIA DOUTORADO O ANTIOXIDANTE QUERCETINA DIMINUI O ESTRESSE OXIDATIVO HEPÁTICO EM RATOS DIABÉTICOS
Dias, A. S., & Alegre, P. (2005) · Cited by 3 · see citing works
The oral subacute toxicological activity of hydroalcoholic extract of Moringa oleifera Lam. (Moringaceae) growing in South West of Burkina Faso in Wistar rats
Somé, A. A., Dabiré, P. A., Da, F. L., et al. (2022) · The Journal of Phytopharmacology · doi:10.31254/phyto.2022.11604 · Cited by 2 · see citing works
Oxidative stress markers in liver in streptozocin-induced diabetic rats: effects of metformin and sitagliptin
Cakina, S., & Öztürk, Ş. (2020) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.791369 · Cited by 2 · see citing works
Effects of Nano-Fipronil on Male Rats’ Biochemical, Liver, and Renal Functions
Al-Janabi, Q. A. A., Hamed, L. N., & Ibraheem, A. K. (2023) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1259/1/012033 · Cited by 1 · see citing works
The Ameliorative Effect of Propolis Extract (bee glue) Against Oxidative Damage Induced by Methotrexate in Rats
El-Rahmany, N. G., Khalıl, F., Ahmed, A. M., et al. (2015) · Journal of Scientific Research in Science /Journal of Scientific Research in Science · doi:10.21608/jsrs.2015.24900 · Cited by 1 · see citing works
Role of vitamin E in modulating the effect of Streptozotocin-induced maternal diabetes on fetal liver development in albino rat
Mohamed, S., Salem, N. A., Hassan, H., et al. (2021) · Medicine Updates · doi:10.21608/muj.2021.93704.1057 · Cited by 1 · see citing works

Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice
Kawai, S., Komura, J., Asada, Y., et al. (1988) · Archives of Dermatological Research · doi:10.1007/bf00456850 · Cited by 37 · see citing works
[The mechanisms of antioxidant against inflammatory lesion in animal oral mucosa. II. A study of glutathione peroxidase].
Zhou, H., Li, B., & Hu, T. (1998) · PubMed
The Effect of Selenium and Vitamin E Supplement on the Serum Concentrations of Antioxidant and F2 Isoprostanes in Arabian Horses during the Training Season
Hassanpour, A., Moghaddam, G., & Mirzaie, H. (2011)
Influence of dietary antioxidants on polychlorinated biphenyls (PCB)-induced hepatic lipid peroxide formation and vitamin A reduction in rats.
Saito, M., Ikegami, S., Ito, Y., et al. (1982) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.28.455 · Cited by 11 · see citing works
Influences of Trace Element Selenium and Vitamin E on Serum Lipid Peroxide,GSH-Px and GPT in Rabbit
Qu, B. (2002) · China Public Health

Authors: Seven, A., Güzel, S., Seymen, O., Civelek, S., Bolayırlı, M., Uncu, M., & Burçak, G.
Affiliations: Istanbul University-Cerrahpaşa (TR)
ORCID: Bolayırlı, Murat
Uncu, Murat
Venue: Yonsei Medical Journal
Publisher: Yonsei University College of Medicine
Published: 2004
Volume: 45
Issue: 4
Pages: 703
ISSN: 0513-5796 (ISSN-L)
DOI: 10.3349/ymj.2004.45.4.703
OpenAlex: W2000677749
Cited by: 109
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 5 · 2013: 5 · 2012: 8
FWCI: 2.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: creativecommons.org/licenses/by-nc/3.0 (tdm)
Locations: Yonsei Medical Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: vitamin E supplementation, oxidative stress, streptozotocin-induced diabetes, lipid peroxidation, antioxidant status, glutathione, superoxide dismutase, glutathione peroxidase, erythrocytes, liver, plasma, diabetes mellitus
MeSH terms: Animals, Antioxidants, Diabetes Mellitus, Experimental, Glutathione, Glutathione Peroxidase, Liver, Male, Superoxide Dismutase, Vitamin E, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Rats

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Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma

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