Hepatokines: unlocking the multi-organ network in metabolic diseases

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

The internal secretion of the pancreas

Banting, F., & BEST, C. H. (1922) · Journal of Laboratory and Clinical Medicine · doi:10.5555/uri:pii:s0022214322903841 · Cited by 785 · see citing works

Effects of parabiosis of obese with diabetes and normal mice.

Coleman, D. L. (1973) · Diabetologia · doi:10.1007/bf01221857 · Cited by 729 · see citing works

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Dushay, J., Chui, P. C., Gopalakrishnan, G. S., Varela–Rey, M., Crawley, M., Fisher, F. M., Badman, M. K., Martinez–Chantar, M. L., & Maratos–Flier, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.054 · Cited by 607 · see citing works

The role of hepatokines in metabolism

Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

Dushay, J. R., Toschi, E., Mitten, E. K., Fisher, F. M., Herman, M. A., & Maratos-Flier, E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.09.008 · Cited by 233 · see citing works

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

Gusarova, V., Alexa, C. A., Na, E., Stevis, P. E., Xin, Y., Bonner-Weir, S., Cohen, J. C., Hobbs, H. H., Murphy, A. J., Yancopoulos, G. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.027 · Cited by 202 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.053 · Cited by 187 · see citing works

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

Yu, H., Xia, F., Lam, K. S., Wang, Y., Bao, Y., Zhang, J., Gu, Y., Zhou, P., Lu, J., Jia, W., et al. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.155184 · Cited by 170 · see citing works

Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice.

Anson, M., Crain‐Denoyelle, A., Baud, V., Chereau, F., Gougelet, A., Terris, B., Yamagoe, S., Colnot, S., Viguier, M., Perret, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci43937 · Cited by 168 · see citing works

FGF21-based pharmacotherapy – potential utility for metabolic disorders

Gimeno, R. E., & Moller, D. E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.03.001 · Cited by 163 · see citing works

Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states

El Ouaamari, A., Kawamori, D., Dirice, E., Liew, C. W., Shadrach, J. L., Hu, J., Katsuta, H., Hollister-Lock, J., Qian, W.-J., Wagers, A. J., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.007 · Cited by 136 · see citing works

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes

Espes, D., Lau, J., & Carlsson, P. (2013) · Diabetologia · doi:10.1007/s00125-013-3071-1 · Cited by 128 · see citing works

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

Cox, A. R., Lam, C. J., Bonnyman, C. W., Chavez, J., Rios, J. S., & Kushner, J. A. (2015) · Diabetologia · doi:10.1007/s00125-015-3590-z · Cited by 66 · see citing works

A link between hepatic glucose production and peripheral energy metabolism via hepatokines

Abdul-Wahed, A., Gautier‐Stein, A., Casteras, S., Soty, M., Roussel, D., Romestaing, C., Guillou, H., Tourette, J.-A., Plèche, N., Zitoun, C., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.005 · Cited by 61 · see citing works

Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

Okumura, A. (2013) · BioScience Trends · doi:10.5582/bst.2013.v7.6.276 · Cited by 57 · see citing works

Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin‐induced insulin‐deficient diabetic mice by restoring brown adipose tissue function

Kim, J. H., Bae, K., Choi, Y. ‐., Go, Y., Choe, M., Jeon, Y. ‐., Lee, H.-M., Koo, S., Perfield, J. W., Harris, R. A., et al. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12408 · Cited by 49 · see citing works

Direct Inhibitory Effects of Pioglitazone on Hepatic Fetuin-A Expression

Ochi, A., Mori, K., Emoto, M., Nakatani, S., Morioka, T., Motoyama, K., Fukumoto, S., Imanishi, Y., Koyama, H., Ishimura, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088704 · Cited by 40 · see citing works

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mohamed, J., Husin, N. N. A., Zariyantey, A. H., & Budin, S. B. (2016) · Sultan Qaboos University medical journal · doi:10.18295/squmj.2016.16.02.002 · Cited by 475 · see citing works

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Cardoso, A. L., Fernandes, A. M. A., Aguilar‐Pimentel, J. A., de Angelis, M. H., Guedes, J. R., Brito, M. A., Ortolano, S., Pani, G., Athanasopoulou, S., Gonos, E. S., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.004 · Cited by 471 · see citing works

The potential of endurance exercise-derived exosomes to treat metabolic diseases

Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463 · see citing works

The role of hepatokines in NAFLD

Stefan, N., Schick, F., Birkenfeld, A. L., Häring, H., & White, M. F. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.01.006 · Cited by 282 · see citing works

Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism

Jegatheesan, P., & Bandt, J. P. D. (2017) · Nutrients · doi:10.3390/nu9030230 · Cited by 280 · see citing works

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works

Pathogenesis of nonalcoholic steatohepatitis

Liu, W., Baker, R. D., Bhatia, T., Zhu, L., & Baker, S. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2161-x · Cited by 225 · see citing works

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works

NAFLD, and cardiovascular and cardiac diseases: Factors influencing risk, prediction and treatment

Targher, G., Corey, K. E., & Byrne, C. D. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.101215 · Cited by 170 · see citing works

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

Iroz, A., Montagner, A., Benhamed, F., Levavasseur, F., Polizzi, A., Anthony, E., Régnier, M., Fouché, E., Lukowicz, C., Cauzac, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.065 · Cited by 128 · see citing works

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

Bourebaba, L., & Marycz, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122033 · Cited by 123 · see citing works

Hepatokines and adipokines in NASH-related hepatocellular carcinoma

Kücükoglu, Ö., Sowa, J., Mazzolini, G. D., Syn, W., & Canbay, A. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.030 · Cited by 114 · see citing works

Exercise-induced secretion of FGF21 and follistatin are blocked by pancreatic clamp and impaired in type 2 diabetes

Hansen, J. S., Pedersen, B. K., Xu, G., Lehmann, R., Weigert, C., & Plomgaard, P. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1681 · Cited by 106 · see citing works

The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes

Oliveira, A. G., Araújo, T. G., Carvalho, B. D. M., Rocha, G. Z., Santos, A., & Saad, M. J. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00503 · Cited by 103 · see citing works

The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox

Karampela, Ι., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00360-2 · Cited by 103 · see citing works

Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells

Jager, J., Aparicio‐Vergara, M., & Aouadi, M. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12483 · Cited by 90 · see citing works

The hepatokines fetuin-A and fetuin-B are upregulated in the state of hepatic steatosis and may differently impact on glucose homeostasis in humans

Peter, A., Kovářová, M., Staiger, H., Machann, J., Schick, F., Königsrainer, A., Königsrainer, I., Schleicher, E. D., Fritsche, A., Häring, H., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2017 · Cited by 82 · see citing works

Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment

Bourebaba, N., Ngo, T., Śmieszek, A., Bourebaba, L., & Marycz, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113261 · Cited by 75 · see citing works

The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes

Guerra, S., & Gastaldelli, A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.016 · Cited by 74 · see citing works

Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis

Yoo, H. J., Hwang, S. Y., Choi, J.-H., Lee, H. J., Chung, H. S., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174717 · Cited by 72 · see citing works

Implication of hepatokines in metabolic disorders and cardiovascular diseases

Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71 · see citing works

Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms

Yang, X., Qiu, K., Jiang, Y., Huang, Y., Zhang, Y., & Liao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147621 · Cited by 69 · see citing works

The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis

Choi, K. M. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.1.1 · Cited by 62 · see citing works

Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study

Karampela, Ι., Kandri, E., Antonakos, G., Vogiatzakis, E. D., Christodoulatos, G. S., Nikolaidou, A., Dimοpoulos, G., Armaganidis, A., & Dalamaga, Μ. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.05.004 · Cited by 58 · see citing works

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies

Roshanzamir, F., Miraghajani, M. S., Rouhani, M. H., Mansourian, M., Ghiasvand, R., & Safavi, S. M. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0697-8 · Cited by 49 · see citing works

Effect of exercise intensity on circulating hepatokine concentrations in healthy men

Willis, S. A., Sargeant, J. A., Thackray, A. E., Yates, T. E., Stensel, D. J., Aithal, G. P., & King, J. A. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0818 · Cited by 48 · see citing works

Organokines in disease

(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46 · see citing works

Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity

Wu, H., Chen, S., Fan, K., Kuo, C., Lin, S., Wang, S., Chang, C., & Li, H. (2019) · The FASEB Journal · doi:10.1096/fj.201901925r · Cited by 43 · see citing works

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Fritsche, K., Ziková, A., Marx‐Stoelting, P., & Braeuning, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032686 · Cited by 42 · see citing works

Organ–Organ Crosstalk and Alcoholic Liver Disease

Poole, L. G., Dolin, C. E., & Arteel, G. E. (2017) · Biomolecules · doi:10.3390/biom7030062 · Cited by 42 · see citing works

Piecing together the puzzle of pancreatic islet adaptation in pregnancy

Banerjee, R. R. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13552 · Cited by 40 · see citing works

Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance

Qu, H., Qiu, Y., Wang, Y., Liao, Y., Zheng, Y., & Zheng, H. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.02.003 · Cited by 38 · see citing works

Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells

Frankó, A., Hartwig, S., Kotzka, J., Ruoß, M., Nussler, A. K., Königsrainer, A., Häring, H., Lehr, S., & Peter, A. (2019) · Nutrients · doi:10.3390/nu11081795 · Cited by 38 · see citing works

Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: A systematic review and Meta-analysis

Ramírez-Vélez, R., García-Hermoso, A., Hackney, A. C., & Izquierdo, M. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0962-2 · Cited by 37 · see citing works

The Hepatic Protection Effects of Hepassocin in Hyperglycemic Crisis

Ou, H., Wu, H., Lin, C.-H., Du, Y., Hu, C., Hung, H., Wu, P., Li, H., Wang, S., & Chang, C. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3287 · Cited by 33 · see citing works

Comparative transcriptome analysis reveals physiological responses in liver tissues of Epinephelus coioides under acute hypoxia stress

Lai, X., Zhang, C., Wu, Y., Yang, Y., Zhang, M., Qin, W., Wang, R., & Shu, H. (2022) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2022.101005 · Cited by 28 · see citing works

Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

Simons, P., Valkenburg, O., van de Waarenburg, M. V. D., van Greevenbroek, M. V., Kooi, M., Jansen, J., Schalkwijk, C., Stehouwer, C., & Brouwers, M. (2022) · Diabetologia · doi:10.1007/s00125-022-05790-7 · Cited by 22 · see citing works

Reciprocal Regulation of Hepatic TGF-β1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure

Pan, Q., Ai, W., Chen, Y., Kim, D. M., Shen, Z., Yang, W., Jiang, W., Sun, Y., Safe, S. H., & Guo, S. (2023) · Diabetes · doi:10.2337/db23-0180 · Cited by 24 · see citing works

Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia

Tanisawa, K., Taniguchi, H., Sun, X., Ito, T., Kawakami, R., Sakamoto, S., & Higuchi, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173310 · Cited by 23 · see citing works

Organokines and Exosomes: Integrators of Adipose Tissue Macrophage Polarization and Recruitment in Obesity

Wang, Y. Y., Wang, Y., Qi, X.-Y., Liao, Z., Mai, Y.-N., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839849 · Cited by 22 · see citing works

The implication of hepatokines in metabolic syndrome

Esfahani, M., Baranchi, M., & Goodarzi, M. T. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.06.027 · Cited by 21 · see citing works

The endocrine role of hepatokines: implications for human health and disease

Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 22 · see citing works

Carbohydrates from Sources with a Higher Glycemic Index during Adolescence: Is Evening Rather than Morning Intake Relevant for Risk Markers of Type 2 Diabetes in Young Adulthood?

Diederichs, T., Herder, C., Roßbach, S., Roden, M., Wudy, S. A., Nöthlings, U., Alexy, U., & Buyken, A. E. (2017) · Nutrients · doi:10.3390/nu9060591 · Cited by 18 · see citing works

Association of serum betatrophin with fibroblast growth factor-21 in women with polycystic ovary syndrome

Kahraman, S., Altınova, A. E., Yalçın, M. M., Gülbahar, Ö., Arslan, B., Aktürk, M., Cakir, N., & Törüner, F. B. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0831-2 · Cited by 17 · see citing works

New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with β-cell dysfunction and dyslipidemia

Kamal, M. M., Adel, A., Sayed, G. H., Ragab, S. H., & Kassem, D. H. (2020) · Translational research · doi:10.1016/j.trsl.2020.12.004 · Cited by 17 · see citing works

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes

Chung, H. S., Lee, H. J., Hwang, S. Y., Choi, J.-H., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Choi, D. S., Baik, S. H., et al. (2018) · International Journal of Endocrinology · doi:10.1155/2018/7918714 · Cited by 17 · see citing works

Expression of angiopoietin-like protein 8 correlates with VEGF in patients with proliferative diabetic retinopathy

Lu, Q., Li, L., Chen, W., & Lu, P. (2017) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-017-3676-z · Cited by 16 · see citing works

Hepatokines: the missing link in the development of insulin resistance and hyperandrogenism in PCOS?

Stefanaki, K., Ilias, Ι., Paschou, S. Α., & Karagiannakis, D. S. (2023) · HORMONES · doi:10.1007/s42000-023-00487-x · Cited by 15 · see citing works

White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease

Rabadán-Chávez, G. M., de la Garza, R. I. D., & Jacobo‐Velázquez, D. A. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166853 · Cited by 14 · see citing works

Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest

Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 13 · see citing works

Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle

He, Y., Qiu, R., Wu, B., Gui, W., Lin, X., Li, H., & Zheng, F. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00495.2020 · Cited by 13 · see citing works

Characterization of FGF21 Sites of Production and Signaling in Mice

Sullivan, A. I., Jensen-Cody, S. O., Claflin, K. E., Vorhies, K., Flippo, K. H., & Potthoff, M. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae120 · Cited by 11 · see citing works

Use of Computation Ecosystems to Analyze the Kidney-Heart Crosstalk

Wu, Z., Lohmöller, J., Kuhl, C. K., Wehrle, K., & Jankowski, J. (2023) · Circulation Research · doi:10.1161/circresaha.123.321765 · Cited by 12 · see citing works

Postweaning changes in the expression of chemerin and its receptors in calves are associated with the modification of glucose metabolism1

Suzuki, Y., Haga, S., Nakano, M., Ishizaki, H., Nakano, M., Song, S. J., Katoh, K., & Roh, S. G. (2016) · Journal of Animal Science · doi:10.2527/jas.2016-0677 · Cited by 11 · see citing works

Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma

Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11 · see citing works

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet

Lutz, S. Z., Hennige, A. M., Peter, A., Kovářová, M., Totsikas, C., Machann, J., Kröber, S. M., Sperl, B., Schleicher, E. D., Schick, F., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01573 · Cited by 8 · see citing works

Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications

Chen, L., Lv, X., Kan, M., Wang, R., Wang, H., & Zang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012464 · Cited by 10 · see citing works

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Zhang, J., Zhang, X., Zhao, Y. Y., & Lv, G. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000484255 · Cited by 10 · see citing works

Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men

Afrisham, R., Paknejad, M., Ilbeigi, D., Sadegh‐Nejadi, S., Gorgani‐Firuzjaee, S., & Vahidi, M. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200601164253 · Cited by 9 · see citing works

Role of oxidative stress, gut microbiota and derived metabolites in the etiology and progression of nonalcoholic fatty liver disease

Das, A., De, A. J., Mohanty, T., & Aich, P. (2023) · Redox Experimental Medicine · doi:10.1530/rem-23-0016 · Cited by 8 · see citing works

Fetuin-A, adiposity-linked insulin resistance and responsiveness to an educational-based weight excess reduction program: a population-based survey in prepubertal schoolchildren

Murdolo, G., Tortoioli, C., Celi, F., Bini, V., Papi, F., Brozzetti, A., & Falorni, A. (2016) · Endocrine · doi:10.1007/s12020-016-1009-3 · Cited by 8 · see citing works

Differential effects of protein intake versus intake of a defined oligopeptide on FGF-21 in obese human subjects in vivo

Fangmann, D., Geisler, C., Schlicht, K., Hartmann, K., Köpke, J., Tiede, A., Settgast, U., Türk, K., Schulte, D. M., Altmann, K., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.006 · Cited by 8 · see citing works

Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease

Chen, S., Liu, Z., Li, C., Wang, J., Zhang, J., Zhang, X., & Xu, C. (2022) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2022/7175108 · Cited by 7 · see citing works

Plasma fetuin-A does not correlate with monocyte TLR4 in humans

Jialal, I., Devaraj, S., & ADAMS-HUET, B. A. (2015) · Diabetologia · doi:10.1007/s00125-015-3809-z · Cited by 7 · see citing works

Clinical and Biochemical Parameters in Relation to Serum Fetuin-A Levels in Overweight and Obese with and without Metabolic Syndrome in the North-eastern States of Indian Population

Eswar, S., Rajagopalan, B., Ete, K., & Gattem, S. N. R. (2024) · JMA Journal · doi:10.31662/jmaj.2024-0104 · Cited by 6 · see citing works

Hepatoprotective Effects of a Ruthenium(II) Schiff Base Complex in Rats with Diet-Induced Prediabetes

Mabuza, L. P., Gamede, M. W., Maikoo, S., Booysen, I. N., Ngubane, P. S., & Khathi, A. (2019) · Current Therapeutic Research · doi:10.1016/j.curtheres.2019.100570 · Cited by 7 · see citing works

Hepatokines and Adipokines in Metabolic Syndrome

Mukhuty, A., Mondal, S. A., & Mukhopadhyay, S. (2023) · Annals of the National Academy of Medical Sciences (India) · doi:10.1055/s-0042-1760087 · Cited by 6 · see citing works

Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients

Deng, X., Cai, Z., Li, Y., Wu, X., Zhao, L., Li, H., Chen, K., Zhang, P., Wang, C., Zhao, Z., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.737624 · Cited by 6 · see citing works

Association between Healthy Eating Index-2010 and Fetuin-A Levels in Patients with Type 2 Diabetes: a Case-Control Study

Roshanzamir, F., Miraghajani, M. S., Mansourian, M., Ghiasvand, R., & Safavi, S. M. (2017) · Clinical Nutrition Research · doi:10.7762/cnr.2017.6.4.296 · Cited by 6 · see citing works

European Obesity Summit (EOS) - Joint Congress of EASOand IFSO-EC, Gothenburg, Sweden, June 1 - 4, 2016: Abstracts

Broek, M., de Heide, L. J. M., Veeger, N. J. G. M., van der Wal-Oost, A. M., & Beek, V. A. (2016) · Obesity Facts · doi:10.1159/000446744 · Cited by 6 · see citing works

Interaction of fetuin-A with obesity related insulin resistance and diabetes mellitus

Öner-İyidoğan, Y., & Koçak, H. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2024-0235 · Cited by 6 · see citing works

"Methanol Fraction of Ethanol Extract of Dialium Guineense Stem Bark Mitigates STZ-Induced Oxidative Stress in Rat Liver"

Abu, O. D. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.51.008085 · Cited by 5 · see citing works

Hub biomarkers and their clinical relevance in glycometabolic disorders: A comprehensive bioinformatics and machine learning approach

Xiang, L., Zhou, B., Luo, Y., Bi, H., Lü, Y., & Zhou, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003525 · Cited by 4 · see citing works

Impacts of Different Modes of Bariatric Surgery on Plasma Levels of Hepassocin in Patients with Diabetes Mellitus

Wu, W., Lee, W., Yeh, C., Chen, S., & Chen, C.-Y. (2019) · Reports — Medical Cases Images and Videos · doi:10.3390/reports2040024 · Cited by 4 · see citing works

Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance

Kobayashi, N., Okazaki, Y., Iwane, A., Hara, K., Horikoshi, M., Awazawa, M., Soeda, K., Matsushita, M., Sasako, T., Yoshimura, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58836-w · Cited by 4 · see citing works

Monounsaturated Fatty Acid Mediated Liver-Adipose Tissue Crosstalk and Metabolic Regulation

Burhans, M. S., & Ntambi, J. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-25065-6_12 · Cited by 4 · see citing works

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

Reinauer, C., Reinehr, T., Bächle, C., Karges, B., Seyfarth, J., Foertsch, K., Schebek, M., Woelfle, J., Roden, M., Holl, R. W., et al. (2017) · Hormone Research in Paediatrics · doi:10.1159/000484896 · Cited by 5 · see citing works

Roles of the interorgan neuronal network in the development of metabolic syndrome

Uno, K. (2016) · Diabetology International · doi:10.1007/s13340-016-0277-8 · Cited by 4 · see citing works

Cardiometabolic Syndrome and Effects of Yoga

Chatterjee, S., & Bhattacharya, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_15 · Cited by 4 · see citing works

Metabolism-related hepatokines change in biliary atresia: ANGPTL6 as a potential biomarker

Fang, D., Hu, S., Tou, J.-F., Dong, F., & Peng, S.-Q. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05675-9 · Cited by 3 · see citing works

Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling

Rada, P., Lamballe, F., Carceller-López, E., Hitos, A. B., Sequera, C., Maina, F., & Valverde, Á. M. (2022) · Cells · doi:10.3390/cells11050793 · Cited by 3 · see citing works

Fetuin-A in association with metabolic syndrome and its components

Singh, M., Sreenivasulu, K., & Choudhary, S. (2021) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20213079 · Cited by 2 · see citing works

Hepatokines modulation in obesity: which exercise training model is better in men with obesity?

Ataeinosrat, A., Abednatanzi, H., Hajesfandiari, S., Nasser, M. N. A., Dara, M. M., Farzanegi, P., Nahand, M. S., Almaqhawi, A., Karimi, N., Bagherzadeh-Rahmani, B., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1560453 · Cited by 3 · see citing works

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis

Teperino, R., Adamová, M., Aljabali, S. M., Pai, S. S., Gerlini, R., Paez-Perez, I., Matz‐Soja, M., Heyne, S., Lempradl, A. M., Basilicata, M. F., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102339 · Cited by 2 · see citing works

Relationship Between Adipose Tissue and Liver Dysfunction in Women with Polycystic Ovary Syndrome and Metabolic Syndrome

de Medeiros, S. F., & Maciel, G. A. R. (2026) · Metabolites · doi:10.3390/metabo16060393 · Cited by 2 · see citing works

Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver

Farsani, Z. H., Faramarzi, M., Karaji, Z. G., Akbarzadeh, H., & Hosseinzadeh, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-01156-2 · Cited by 2 · see citing works

Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis

Alduraywish, A. A. (2017) · Journal of Endocrinology and Metabolism · doi:10.14740/jem405w · Cited by 2 · see citing works

Le discours polyphonique des manuels de Biologie en Tunisie : exemple de la régulation de la glycémie

Garbouj-Dhouibi, M., & Schneeberger, P. (2020) · Éducation & didactique · doi:10.4000/educationdidactique.7907 · Cited by 1 · see citing works

Study of Serum Betatrophin Level in The Patients of Type 2 Diabetes Mellitus

El-Ghandour, A. H., El-Bendary, A. S., Shahba, A., & Soliman, G. A. (2019) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2019.28682 · Cited by 1 · see citing works

High serum EDA concentration is associated with metabolic syndrome and its determinants

Deng, X., Li, Y., Gu, T., Wu, X., Sun, Z., Li, H., Yang, L., & Yuan, G. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02408-9 · Cited by 1 · see citing works

Hepatokines as Biomarkers of Obesity-Associated Liver Pathophysiology: Deciphering Advances in Basic and Clinical Aspects

Ishtiaq, S. M. (2023) · Advances in Pharmacology & Clinical Trials · doi:10.23880/apct-16000228 · Cited by 1 · see citing works

Diabetologia at 50: celebrating half a century of progress in diabetes research and care

Zierath, J. R. (2015) · Diabetologia · doi:10.1007/s00125-015-3640-6

Betatrophin in nonalcoholic fatty liver disease

Gürel, H., & Doğru, T. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000571

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

Sotiriou, A. (2016) · doi:10.18174/399762

Adipose Tissue-Liver Axis: a key Link in Adiposity

Rosero, R., Am, G., Palacio, J. I., Jaramillo, A. U., & Polanco, J. P. (2019) · Diabetes & its Complications · doi:10.33425/2639-9326.1042

PATHOGENESIS OF THE MORPHOFUNCTIONAL STATE DISORDERS OF THE LIVER IN DIABETES MELLITUS TYPE 1

Ткачук, О. В., Тkachuk, S. S., Povar, M. A., Boshtan, S. V., & Sorokhan, V. D. (2020) · Clinical & experimental pathology · doi:10.24061/1727-4338.xix.2.72.2020.14

Increased Circulating Levels of EDA in Newly Diagnosed Type 2 Diabetic PatientsPreprint

Deng, X., Li, Y., Wu, X., Zhao, L., Li, H., Chen, K., Zhang, P., Zhao, Z., Qiu, Y., Yang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-189239/v1

An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes

Altunoğlu, E., Erdenen, F., Seda, A., Atakan, K., & Hafize, U. (2021) · Annals of Endocrinology and Metabolism · doi:10.36959/433/568

Dietary Fructose and Glucose: The Multifacetted Aspects of Their Metabolism and Implication for Human Health

Tappy, L. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-054-5

The endocrine role of hepatokines: implications for human health and disease

Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 22 · see citing works

The role of hepatokines in metabolism

Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works

Key Hepatokines Linking MASLD and Type 2 Diabetes: From Pathophysiological Mechanisms to Therapeutic Modulation

Foia, L. G., Goriuc, A., Luchian, I. A., Budală, D. G., Toma, V., Bogdán, M., Minea, B., & Ghemiș, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177917

Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation

Miao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 34 · see citing works

Interaction between hepatokines and metabolic diseases.

Liang, J., Liu, C., Zhang, W., & Chen, S. (2022) · PubMed · doi:10.16288/j.yczz.22-218 · Cited by 3 · see citing works