The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The role of cell adhesion molecule in cancer progression and its application in cancer therapy.
Open accessAbstract
Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins has been identified that mediates the cell-cell and cell-extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.
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Cites
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Epithelial Cell Adhesion Molecule
Trzpis, M., McLaughlin, P. M. J., de Leij, L. M. F. H., & Harmsen, M. C. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070152 · Cited by 578
Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties
Ferrari, M., Cirisano, F., & Morán, M. C. (2019) · Colloids and Interfaces · doi:10.3390/colloids3020048 · Cited by 227
Breast cancer models: Engineering the tumor microenvironment
Bahcecioglu, G., Basara, G., Ellis, B. W., Ren, X., & Zorlutuna, P. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.006 · Cited by 213
Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models
Skobowiat, C., Oak, A. S. W., Kim, T.-K., Yang, C. H., Pfeffer, L. M., Tuckey, R. C., & Slominski, A. T. (2017) · Oncotarget · doi:10.18632/oncotarget.14193 · Cited by 44
Metadata
- Authors
- Okegawa, T., Pong, R.-C., Li, Y., & Hsieh, J.-T.
- Venue
- Acta Biochimica Polonica
- Publisher
- Frontiers Media SA
- Published
- 2004-06-30
- Volume
- 51
- Issue
- 2
- Pages
- 445-457
- ISSN
- 0001-527X (ISSN-L)
- 1734-154X
- OpenAlex
- W2152776641
- Cited by
- 305
- References
- 57
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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