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Cited by 227Surface Modification and SuperhydrophobicityPolymer Surface Interaction StudiesCellular Mechanics and Interactions

Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties

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Ferrari, Michele, Cirisano, Francesca, Morán, M. Carmen·2019·Colloids and Interfaces
DOI 10.3390/colloids3020048
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Abstract

The influence of different surface properties holding to a modification of the substrate towards hydrophobic or superhydrophobic behavior was reviewed in this paper. Cell adhesion, their communication, and proliferation can be strongly manipulated, acting on interfacial relationship involving stiffness, surface charge, surface chemistry, roughness, or wettability. All these features can play mutual roles in determining the final properties of biomedical applications ranging from fabrics to cell biology devices. The focus of this work is the mammalian cell viability in contact with moderate to highly water repellent coatings or materials and also in combination with hydrophilic areas for more specific application. Few case studies illustrate a range of examples in which these surface properties and design can be fruitfully matched to the specific aim.

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  • PCL maintains structural integrity for weeks to months, making it highly suitable for adhesion-prevention applications.

    “PCL maintains structural integrity for weeks to months, making it highly suitable for adhesion-prevention applications [196].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [196]

    The Case Studies section discusses anti-adhesive biomaterials and tissue-adhesion barriers generally, but does not establish this claim about PCL. Searches for “PCL,” “polycaprolactone,” and structural integrity over weeks or months found no passage addressing PCL’s durability or suitability for adhesion prevention. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Ferrari, M., Cirisano, F., & Morán, M. C.
Affiliations
  • Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona (ES)
  • CNR-ICMATE Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia, via De Marini, 6, 16149 Genova, Italy
Corresponding author
  • Ferrari, Michele
  • Morán, M. Carmen
ORCID
Venue
Colloids and Interfaces
Publisher
MDPI AG
Published
2019-05-07
Volume
3
Issue
2
Pages
48
ISSN
2504-5377 (ISSN-L)
DOI
10.3390/colloids3020048
OpenAlex
W2944367923
Cited by
227
References
5
Citations by year
2026: 19 · 2025: 34 · 2024: 31 · 2023: 32 · 2022: 45 · 2021: 33 · 2020: 31 · 2019: 1 · 2015: 1
FWCI
8.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Colloids and Interfaces (publishedVersion, cc-by)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
hydrophobic substrates, superhydrophobic surfaces, cell proliferation, cell viability, wettability, surface roughness, surface charge, surface chemistry, substrate stiffness, water-repellent coatings, intercellular communication, biomedical applications

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