The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions.
Open accessAbstract
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.
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Citations
Cites
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
Melatonin Reduces Oxidative Damage of Neural Lipids and Proteins in Senescence-Accelerated Mouse
Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00005-2 · Cited by 112
Self-citationMyeloperoxidase-catalyzed oxidation of melatonin by activated neutrophils
de Oliveira Silva, S., Ximenes, V. F., Catalani, L. H., & Campa, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3993 · Cited by 72
Cited by
Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461
Is Melatonin the Cornucopia of the 21st Century?
Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M. G., Rizzo, V., Currò, M., Ientile, R., & Caccamo, D. (2020) · Antioxidants · doi:10.3390/antiox9111088 · Cited by 189
Mohammadi-Sartang, M., Ghorbani, M., & Mazloom, Z. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.11.003 · Cited by 94
Chen, Z.-M., Li, Q., Liu, H.-M., Yu, N., Xie, T.-J., Yang, M.-Y., Shen, P., & Chen, X.-D. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2162-x · Cited by 72
Metadata
- Authors
- Reiter, R. J., Tan, D.-X., Terron, M. P., Flores, L. J., & Czarnocki, Z.
- Venue
- Acta Biochimica Polonica
- Publisher
- Frontiers Media SA
- Published
- 2007-03-09
- Volume
- 54
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0001-527X (ISSN-L)
- 1734-154X
- OpenAlex
- W1964130521
- Cited by
- 378
- References
- 3
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
