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Cited by 94Circadian rhythm and melatoninDietary Effects on HealthLipoproteins and Cardiovascular Health

Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials

Mohammadi-Sartang, Mohsen, Ghorbani, Mohammad, Mazloom, Zohreh·2018·Clinical Nutrition
DOI 10.1016/j.clnu.2017.11.003
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Abstract

Background & aims Melatonin supplementation may be associated with blood lipids improvement; however, the current evidence from randomized controlled trials (RCTs) is inconsistent. The present study aimed to systematically review and analyze RCTs assessing the effects of melatonin supplementation on blood lipids.Methods A comprehensive literature search in several database was performed up to January 2017. Quantitative data synthesis was performed using a fixed or random-effects model, with weight mean difference (WMD) and 95% confidence intervals (CI). Standard methods were used for assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias.Results A total of 8 RCTs were eligible. Meta-analysis suggested a significant association between melatonin supplementation and a reduction in triglycerides (WMD: -31.54 mg/dL, 95% CI: -50.71, -12.38, p = 0.001), and total cholesterol levels (WMD: -18.48 mg/dL, 95% CI: -35.33, -1.63, p = 0.032), while no significant effect on LDL-C (WMD: -2.37 mg/dL, 95% CI: -11.61, -6.86, p = 0.615) and HDL-C (WMD: 1.28 mg/dL, 95% CI: -0.66, 3.23, p = 0.197) was found. In sub-group analysis, a significant decrease in triglycerides was found at doses ≥8 mg/d and when trials last ≥8 weeks. In addition, a significant decrease of total cholesterol was found at doses ≥8 mg/d and when total cholesterol baseline levels were ≥200 mg/dL.Conclusions Melatonin supplementation has significant effects on triglycerides and total cholesterol levels, which was more evident in higher dose and longer duration and also in a higher concentration of cholesterol levels. Further studies are required to determine the benefits of melatonin on lipid profile.

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  • A new systematic review and meta-analysis of RCTs demonstrated the beneficial impacts of melatonin consumption on lipids at doses greater than 8 mg/d and long durations of more than 8 weeks including a notable reduction in TG, TC, and a small reduction in LDL-c and HDL-c.

    “In agreement with our results, a new systematic review and meta-analysis of RCTs demonstrated the beneficial impacts of melatonin consumption on lipids at doses greater than 8 mg/d and long durations of more than 8 weeks including a notable reduction in TG, TC, and a small reduction in LDL-c and HDL-c. 33”

    From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [33]

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Authors
Mohammadi-Sartang, M., Ghorbani, M., & Mazloom, Z.
Affiliations
  • Torbat Heydarieh University of Medical Sciences (IR)
  • Shiraz University of Medical Sciences (IR)
Corresponding author
Mazloom, Zohreh
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2018-12
Volume
37
Issue
6
Pages
1943-1954
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2017.11.003
OpenAlex
W2770508056
Cited by
94
References
58
Citations by year
2026: 11 · 2025: 6 · 2024: 17 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 17 · 2019: 10 · 2018: 6
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
melatonin supplementation, serum lipids, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, lipid profile, dose-response relationship, duration of supplementation, hypercholesterolemia
MeSH terms
Adult, Aged, Cholesterol, Female, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Melatonin, Middle Aged, Triglycerides, Randomized Controlled Trials as Topic, Dietary Supplements

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