The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications
Open accessAbstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are used chronically to reduce pain and inflammation in patients with arthritic conditions, and also acutely as analgesics by many patients. Both therapeutic and adverse effects of NSAIDs are due to inhibition of cyclooxygenase (COX) enzyme. NSAIDs are classified as non-selective and COX-2-selective inhibitors (COXIBS) based on their extent of selectivity for COX inhibition. However, regardless of their COX selectivity, reports are still appearing on the GI side effect of NSAIDs particularly on the lower gastrointestinal (GI) tract and the harmful role of their controlled release formulations. In addition, previously unpublished data stored in the sponsor’s files, question the GI sparing properties of rofecoxib, a COXIB that has been withdrawn due to cardiovascular (CV) side effects. Presently, the major side effects of NSAIDs are the GI complications, renal disturbances and CV events. There is a tendency to believe that all NSAIDs are associated with renal and CV side effects, a belief that is not supported by solid evidence. Indeed, lower but still therapeutics doses of some NSAIDs may be cardioprotective. In this review, we briefly discuss the GI toxicity of the NSAIDs and assess their renal and CV adverse effects in more detail. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
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Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
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Cited by
Ungprasert, P., Cheungpasitporn, W., Crowson, C. S., & Matteson, E. L. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.03.008 · Cited by 322
Sohail, R., Mathew, M., Patel, K. K., Reddy, S. A., Haider, Z., Naria, M., Habib, A., Abdin, Z. U., Razzaq Chaudhry, W., & Akbar, A. (2023) · Cureus · doi:10.7759/cureus.37080 · Cited by 239
Polydeoxyribonucleotide Regulation of Inflammation
Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Advances in Wound Care · doi:10.1089/wound.2019.1031 · Cited by 33
Cardiorenal Safety of OTC Analgesics
White, W. B., Kloner, R. A., Angiolillo, D. J., & Davidson, M. H. (2018) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417751070 · Cited by 31
(2015) · PubMed · Cited by 23
Metadata
- Authors
- Harirforoosh, S., Asghar, W., & Jamali, F.
- Venue
- Journal of Pharmacy & Pharmaceutical Sciences
- Publisher
- Frontiers Media SA
- Published
- 2014-01-27
- Volume
- 16
- Issue
- 5
- Pages
- 821
- ISSN
- 1482-1826 (ISSN-L)
- OpenAlex
- W1575211640
- Cited by
- 960
- References
- 158
- FWCI
- 26.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Harirforoosh, S., Asghar, W., & Jamali, F. (2014). Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications. Journal of Pharmacy & Pharmaceutical Sciences. https://doi.org/10.18433/j3vw2f
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
