Polydeoxyribonucleotide Regulation of Inflammation
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Significance: Dysregulated inflammation is a critical factor in the development of a wide range of diseases. Controlling inflammatory responses can be challenging because available treatment options are often limited. This review discusses the ability of polydeoxyribonucleotides (PDRN) to modulate inflammation and the evidence that supports it.
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PDRN downregulates proinflammatory cytokine expression across various in vitro and in vivo disease models.
“Although research on the dermatological effects of PDRN is limited, accumulating evidence indicates that PDRN downregulates proinflammatory cytokine expression across various in vitro and in vivo disease models [126].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [126]
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Polynucleotides: The crucial biomolecules bridging therapeutics and aesthetics
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Polynucleotides and polydeoxyribonucleotides in dermatology – A narrative review
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Nanoformulated PDRN Improves Anti‐Inflammatory and Wound Healing Activities
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- Authors
- Colangelo, M. T., Galli, C., & Guizzardi, S.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Galli, Carlo
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2020-10-01
- Volume
- 9
- Issue
- 10
- Pages
- 576-589
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- PMC
- PMC7585621
- OpenAlex
- W3010731284
- Cited by
- 33
- References
- 84
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 5 · 2023: 3 · 2021: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Advances in Wound Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- polydeoxyribonucleotide, inflammation, anti-inflammatory activity, wound healing
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