The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery
Open accessAbstract
Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of producing real-time non-invasive images without significant biological effects. However, the propagation of higher energy, intensity and frequency ultrasound waves through living tissues can induce thermal, mechanical and chemical effects useful for a variety of therapeutic applications. With the recent development of clinically approved High Intensity Focused Ultrasound (HIFU) systems, therapeutic ultrasound is now a medical reality. Indeed, HIFU has been used for the thermal ablation of pathological lesions; localized, minimally invasive ultrasound-mediated drug delivery through the transient formation of pores on cell membranes; the temporary disruption of skin and the blood brain barrier; the ultrasound induced break-down of blood clots; and the targeted release of drugs using ultrasound and temperature sensitive drug carriers. This review seeks to engage the pharmaceutical research community by providing an overview on the biological effects of ultrasound as well as highlighting important therapeutic applications, current deficiencies and future directions.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.046 · Cited by 679
Ranjan, A., Jacobs, G. C., Woods, D. L., Negussie, A. H., Partanen, A., Yarmolenko, P. S., Gacchina, C. E., Sharma, K. V., Frenkel, V., Wood, B. J., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.011 · Cited by 267 · cited 1×
“successfully sparing adjacent tissues from Dox uptake (147).”
BackgroundFocal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening
Alonso, A., Reinz, E., Leuchs, B., Kleinschmidt, J., Fatar, M., Geers, B., Lentacker, I., Hennerici, M. G., de Smedt, S. C., & Meairs, S. (2013) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2012.64 · Cited by 93
Cited by
A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications
Jiang, X., Savchenko, O., Li, Y., Qi, S., Yang, T., Zhang, W., & Chen, J. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2018.2889669 · Cited by 353
Mechanochemical bond scission for the activation of drugs
Huo, S., Zhao, P., Shi, Z., Zou, M., Yang, X., Warszawik, E., Loznik, M., Göstl, R., & Herrmann, A. (2021) · Nature Chemistry · doi:10.1038/s41557-020-00624-8 · Cited by 322
Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release
Wang, J., Kaplan, J. A., Colson, Y. L., & Grinstaff, M. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.001 · Cited by 126
Metadata
- Authors
- Phenix, C. P., Togtema, M., Pichardo, S., Zehbe, I., & Curiel, L.
- Venue
- Journal of Pharmacy & Pharmaceutical Sciences
- Publisher
- Frontiers Media SA
- Published
- 2014-03-31
- Volume
- 17
- Issue
- 1
- Pages
- 136
- ISSN
- 1482-1826 (ISSN-L)
- OpenAlex
- W2108920393
- Cited by
- 161
- References
- 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery. https://app.cochat.ai/papers/10.18433/j3zp5f
- The paper
- Phenix, C. P., Togtema, M., Pichardo, S., Zehbe, I., & Curiel, L. (2014). High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery. Journal of Pharmacy & Pharmaceutical Sciences. https://doi.org/10.18433/j3zp5f
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
