The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications
Abstract
Ultrasound therapy has a long history of novel applications in medicine. Compared to high-intensity ultrasound used for tissue heating, low-intensity ultrasound has drawn increasing attention recently due to its ability to induce therapeutic changes without biologically significant temperature increase. Low-intensity pulsed ultrasound (LIPUS) is a specific type of ultrasound that delivers at a low intensity and outputs in the mode of pulsed waves. It has minimal thermal effects while maintaining the transmission of acoustic energy to the target tissue, which is able to provide noninvasive physical stimulation for therapeutic applications. LIPUS has been demonstrated to accelerate the healing of fresh fracture, nonunion and delayed union in both animal and clinical studies. The effectiveness of LIPUS for the applications of soft-tissue regeneration and inhibiting inflammatory responses has also been investigated experimentally. Additionally, research has shown that LIPUS is a promising modality for neuromodulation. The purpose of this review is to provide an overview of the recent developments of LIPUS for therapeutic applications, based on the papers that report positive effects, and to present the findings on the understanding of its mechanism. Current available LIPUS devices are also briefly described in this paper.
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Cites
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Regulatory interactions between muscle and the immune system during muscle regeneration
Tidball, J. G., & Villalta, S. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2009 · Cited by 1,105 · cited 1×
“and transcriptional activities of the regeneration process [109].”
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007
Applications of ultrasound in analysis, processing and quality control of food: A review
Awad, T. S., Moharram, H. A., Shaltout, O. E., Asker, D., & Youssef, M. M. (2012) · Food Research International · doi:10.1016/j.foodres.2012.05.004 · Cited by 996
Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
Tufail, Y., Matyushov, A., Baldwin, N., Tauchmann, M. L., Georges, J., Yoshihiro, A., Tillery, S. I. H., & Tyler, W. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.008 · Cited by 977
Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.
Heckman, J. D., Ryaby, J. P., McCabe, J., Frey, J. J., & Kilcoyne, R. F. (1994) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199401000-00004 · Cited by 956
Noninvasive Human Brain Stimulation
Wagner, T., Valero-Cabre, A., & Pascual-Leone, A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.061206.133100 · Cited by 873
Overview of Therapeutic Ultrasound Applications and Safety Considerations
Miller, D. L., Smith, N. B., Bailey, M. R., Czarnota, G. J., Hynynen, K., Makin, I. R. S., & Bioeffects Committee of the American Institute of Ultrasound in Medicine (2012) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2012.31.4.623 · Cited by 752
Therapeutic applications of ultrasound
ter Haar, G. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.005 · Cited by 721
Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound
Tyler, W. J., Tufail, Y., Finsterwald, M., Tauchmann, M. L., Olson, E. J., & Majestic, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003511 · Cited by 707
Metadata
- Authors
- Jiang, X., Savchenko, O., Li, Y., Qi, S., Yang, T., Zhang, W., & Chen, J.
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2019-10
- Volume
- 66
- Issue
- 10
- Pages
- 2704-2718
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2906406205
- Cited by
- 353
- References
- 103
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jiang, X., Savchenko, O., Li, Y., Qi, S., Yang, T., Zhang, W., & Chen, J. (2019). A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications. IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/tbme.2018.2889669
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