Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders
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gene may have potential influence on the pathogenesis of neurodegenerative diseases.
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SIAH3 has been associated through another GWAS with rate of ventricular enlargement in the ADNI cohort, and this association has also been observed separately with variants near CLU.
“In addition, SIAH3 has been associated through another GWAS to rate of ventricular enlargement in the ADNI cohort [42], an association that has also been separately observed with variants near CLU [43].”
From Genetic associations with age at dementia onset in the <i>PSEN1 E280A</i> Colombian kindred (2023) · cites this paper as [42]
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Genetic associations with age at dementia onset in the <i>PSEN1 E280A</i> Colombian kindred
Cochran, J. N., Acosta‐Uribe, J., Esposito, B. T., Madrigal, L., Aguillón, D., Giraldo, M. M., Taylor, J. W., Bradley, J., Fulton‐Howard, B., Andrews, S. J., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13021 · Cited by 21 · see citing works
- Authors
- Li, X., Initiative, O. B. O. A. D. N., Chu, S.-G., Shen, X.-N., Hou, X.-H., Xu, W., Ou, Y.-N., Dong, Q., Tan, L., & Yu, J.-T.
- Affiliations
- Dalian Medical University (CN)
- Tongji University (CN)
- Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
- Qingdao University (CN)
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Tan, Lan
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2019-11-11
- Volume
- 11
- Issue
- 21
- Pages
- 9862-9874
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6874439
- OpenAlex
- W2988699230
- Cited by
- 7
- References
- 48
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571245)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- ventriculomegaly, brain atrophy, non-demented elderly, neurodegenerative disease risk, genetic susceptibility, genome-wide association study
- MeSH terms
- Seven in Absentia Proteins, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cerebral Ventricles, Dementia, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nuclear Proteins, Phenotype, Cohort Studies, Linkage Disequilibrium, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Ubiquitin-Protein Ligases, Genome-Wide Association Study, Genetic Loci, Neuroimaging, Cognitive Dysfunction
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