Heritability of brain ventricle volume: Converging evidence from inconsistent results

Kremen, William S.; Panizzon, Matthew S.; Neale, Michael C.; Fennema-Notestine, Christine; Prom-Wormley, Elizabeth; Eyler, Lisa T.; Stevens, Allison; Franz, Carol E.; Lyons, Michael J.; Grant, Michael D.; Jak, Amy J.; Jernigan, Terry L.; Xian, Hong; Fischl, Bruce; Thermenos, Heidi W.; Seidman, Larry J.; Tsuang, Ming T.; Dale, Anders M.

doi:10.1016/j.neurobiolaging.2010.02.007

Cited by 50Cognitive Abilities and TestingGenetic Associations and EpidemiologyCerebrospinal fluid and hydrocephalus

Heritability of brain ventricle volume: Converging evidence from inconsistent results

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Kremen, William S., Panizzon, Matthew S., Neale, Michael C., Fennema-Notestine, Christine, Prom-Wormley, Elizabeth, Eyler, Lisa T., Stevens, Allison, Franz, Carol E. +10 more·2012·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2010.02.007PMC PMC3221930

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Abstract

Twin studies generally show great consistency for the heritability of brain structures. Ironically, the lateral ventricles--perhaps the most reliably measured brain regions of interest--are the most inconsistent when it comes to estimating genetic influences on their volume. Heritability estimates in twin studies have ranged from zero to almost 0.80. Here we aggregate heritability estimates from extant twin studies, and we review and reinterpret some of the findings. Based on our revised estimates, we conclude that lateral ventricular volume is indeed heritable. The weighted average heritability of the revised estimates was 0.54. Although accumulated environmental insults might seem most logical as the predominant cause of age-related ventricular expansion, the data strongly suggest that genetic influences on lateral ventricular volume are increasing with age. Genetic influences accounted for 32-35% of the variance in lateral ventricular volume in childhood, but about 75% of the variance in late middle and older age. These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging.

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Structure-based endophenotypes are heritable.
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Genetic and environmental influences on the size of specific brain regions in midlife: The VETSA MRI study
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Brain structure in men remains highly heritable in the seventh and eighth decades of life☆
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Authors: Kremen, W. S., Panizzon, M. S., Neale, M. C., Fennema-Notestine, C., Prom-Wormley, E., Eyler, L. T., Stevens, A., Franz, C. E., Lyons, M. J., Grant, M. D., Jak, A. J., Jernigan, T. L., Xian, H., Fischl, B., Thermenos, H. W., Seidman, L. J., Tsuang, M. T., & Dale, A. M.
Affiliations: University of California San Diego (US)
Virginia Commonwealth University (US)
Massachusetts General Hospital (US)
Boston University (US)
Washington University in St. Louis (US)
Harvard University (US)
Corresponding author: Kremen, William S.
ORCID: Kremen, William S.
Panizzon, Matthew S.
Neale, Michael C.
Eyler, Lisa T.
Stevens, Allison
Franz, Carol E.
Lyons, Michael J.
Jak, Amy J.
Jernigan, Terry L.
Xian, Hong
Fischl, Bruce
Seidman, Larry J.
Tsuang, Ming T.
Dale, Anders M.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2012-01
Volume: 33
Issue: 1
Pages: 1-8
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2010.02.007
PMC: PMC3221930
OpenAlex: W1988649618
Cited by: 50
References: 33
Citations by year: 2026: 1 · 2025: 3 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 1
FWCI: 0.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Aging (AG022381, AG018384, AG018386, AG022982)
National Center for Research Resources (P41-RR14075)
National Institute for Biomedical Imaging and Bioengineering (R01EB006758)
National Institute for Neurological Disorders and Stroke (R01 NS052585-01)
National Institutes of Health (U54 EB005149)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords: lateral ventricle volume, heritability, twin studies, brain aging, genetic factors, environmental insults, brain structure genetics
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cerebral Ventricles, Child, Humans, Middle Aged, Organ Size, Sample Size, Twin Studies as Topic, Young Adult, Gene-Environment Interaction

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Heritability of brain ventricle volume: Converging evidence from inconsistent results

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